Gene: ENSMUSG00000052374 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000052374
Transcript Identifier
ENSMUST00000168193
Gene Type
Coding gene
Location
13 : 12269494-12340500 : negative

Family Information

Homologous gene family
HOM03P000481
(99 genes in 11 species)
specific family
Orthologous gene family
ORTHO03P006041
(14 genes in 10 species)
specific family

Descriptions

gene_descr
actinin alpha 2

Identifiers

Type Value
UniprotQ9JI91
MGI109192

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006936
IDA
Genome Projectmuscle contraction
GO:0030035
ISO
IEA
Genome Projectmicrospike assembly
GO:0042391
ISO
IEA
Genome Projectregulation of membrane potential
GO:0043267
ISO
IEA
Genome Projectnegative regulation of potassium ion transport
GO:0043268
ISO
IEA
Genome Projectpositive regulation of potassium ion transport
GO:0045214
ISO
Genome Projectsarcomere organization
GO:0048041
ISO
IEA
Genome Projectfocal adhesion assembly
GO:0051289
ISO
IEA
Genome Projectprotein homotetramerization
GO:0051695
ISO
Genome Projectactin filament uncapping
GO:0055013
IMP
Genome Projectcardiac muscle cell development
GO:0086097
ISO
Genome Projectphospholipase C-activating angiotensin-activated signaling pathway
GO:0090002
IMP
ISO
Genome Projectestablishment of protein localization to plasma membrane
GO:1901017
ISO
IEA
Genome Projectnegative regulation of potassium ion transmembrane transporter activity
GO:1901018
ISO
IEA
Genome Projectpositive regulation of potassium ion transmembrane transporter activity
GO:1903506
IDA
Genome Projectregulation of nucleic acid-templated transcription
GO:2000009
ISO
IEA
Genome Projectnegative regulation of protein localization to cell surface
GO:2000273
IDA
Genome Projectpositive regulation of receptor activity
GO:2001137
IMP
ISO
Genome Projectpositive regulation of endocytic recycling
GO:2001259
IMP
ISO
Genome Projectpositive regulation of cation channel activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003779
IEA
Genome Projectactin binding
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005546
ISO
Genome Projectphosphatidylinositol-4,5-bisphosphate binding
GO:0008092
IDA
ISO
IEA
Genome Projectcytoskeletal protein binding
GO:0019904
ISO
Genome Projectprotein domain specific binding
GO:0030274
IPI
Genome ProjectLIM domain binding
GO:0030374
IDA
Genome Projectligand-dependent nuclear receptor transcription coactivator activity
GO:0030375
IDA
Genome Projectthyroid hormone receptor coactivator activity
GO:0030674
TAS
Genome Projectprotein binding, bridging
GO:0031432
ISO
IEA
Genome Projecttitin binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0042803
ISO
TAS
Genome Projectprotein homodimerization activity
GO:0044325
IPI
ISO
IEA
Genome Projection channel binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046983
ISO
IEA
Genome Projectprotein dimerization activity
GO:0051015
IDA
TAS
Genome Projectactin filament binding
GO:0051373
ISO
IEA
Genome ProjectFATZ binding
GO:0070080
ISO
IEA
Genome Projecttitin Z domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005865
TAS
Genome Projectstriated muscle thin filament
GO:0005925
ISO
IEA
Genome Projectfocal adhesion
GO:0030017
IDA
Genome Projectsarcomere
GO:0030018
IDA
ISO
IEA
Genome ProjectZ disc
GO:0030175
ISO
IEA
Genome Projectfilopodium
GO:0030864
IEA
Genome Projectcortical actin cytoskeleton
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0005886
ISO
Genome Projectplasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001589Actinin-type actin-binding domain, conserved site
IPR001715Calponin homology domain
IPR002017Spectrin repeat
IPR002048EF-hand domain
IPR011992EF-hand domain pair
IPR014837EF-hand, Ca insensitive
IPR018159Spectrin/alpha-actinin

No MapMan annotations defined for this gene.