Gene: ENSMUSG00000050965 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000050965
Transcript Identifier
ENSMUST00000059595
Gene Type
Coding gene
Location
11 : 107939516-108343667 : negative

Family Information

Homologous gene family
HOM03P000015
(1237 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P005549
(15 genes in 6 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
protein kinase C, alpha

Identifiers

Type Value
UniprotQ4VA93
MGI97595

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000188
IMP
Genome Projectinactivation of MAPK activity
GO:0001933
IMP, IGI
Genome Projectnegative regulation of protein phosphorylation
GO:0001934
IMP
Genome Projectpositive regulation of protein phosphorylation
GO:0001938
ISO
IEA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002026
IMP
Genome Projectregulation of the force of heart contraction
GO:0002062
IDA
Genome Projectchondrocyte differentiation
GO:0002159
ISO
IEA
Genome Projectdesmosome assembly
GO:0006468
IDA
ISO
IEA
Genome Projectprotein phosphorylation
GO:0006469
IMP
Genome Projectnegative regulation of protein kinase activity
GO:0006874
IMP
Genome Projectcellular calcium ion homeostasis
GO:0006937
IMP
Genome Projectregulation of muscle contraction
GO:0008285
IGI
Genome Projectnegative regulation of cell proliferation
GO:0010595
ISO
IEA
Genome Projectpositive regulation of endothelial cell migration
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030335
ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0030593
IMP
Genome Projectneutrophil chemotaxis
GO:0031666
ISO
IEA
Genome Projectpositive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351
ISO
IEA
Genome Projectnegative regulation of glial cell apoptotic process
GO:0035408
ISO
IEA
Genome Projecthistone H3-T6 phosphorylation
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0036289
IDA
Genome Projectpeptidyl-serine autophosphorylation
GO:0043536
ISO
IEA
Genome Projectpositive regulation of blood vessel endothelial cell migration
GO:0045766
ISO
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045785
ISO
IEA
Genome Projectpositive regulation of cell adhesion
GO:0045931
ISO
IEA
Genome Projectpositive regulation of mitotic cell cycle
GO:0046325
IMP
Genome Projectnegative regulation of glucose import
GO:0046627
IMP
Genome Projectnegative regulation of insulin receptor signaling pathway
GO:0050729
IMP
Genome Projectpositive regulation of inflammatory response
GO:0050730
IMP
Genome Projectregulation of peptidyl-tyrosine phosphorylation
GO:0050930
IMP
Genome Projectinduction of positive chemotaxis
GO:0070555
ISO
IEA
Genome Projectresponse to interleukin-1
GO:0071322
IDA
Genome Projectcellular response to carbohydrate stimulus
GO:0090330
ISO
IEA
Genome Projectregulation of platelet aggregation
GO:0097193
IMP
Genome Projectintrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
ISO
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004697
IDA
IEA
Genome Projectprotein kinase C activity
GO:0004698
IDA
Genome Projectcalcium-dependent protein kinase C activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0035403
ISO
IEA
Genome Projecthistone kinase activity (H3-T6 specific)
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001750
IDA
Genome Projectphotoreceptor outer segment
GO:0005634
IDA
Genome Projectnucleus
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005739
IDA
ISO
IEA
Genome Projectmitochondrion
GO:0005783
ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005829
ISO
IEA
Genome Projectcytosol
GO:0005886
IDA
ISO
IEA
Genome Projectplasma membrane
GO:0016020
IDA
Genome Projectmembrane
GO:0030425
IDA
Genome Projectdendrite
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0045177
IDA
Genome Projectapical part of cell
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000008C2 domain
IPR000719Protein kinase domain
IPR000961AGC-kinase, C-terminal
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR014375Protein kinase C, alpha/beta/gamma types
IPR017441Protein kinase, ATP binding site
IPR020454Diacylglycerol/phorbol-ester binding

No MapMan annotations defined for this gene.