Gene: ENSMUSG00000049717 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000049717
Transcript Identifier
ENSMUST00000170033
Gene Type
Coding gene
Location
8 : 9971043-9973778 : negative

Family Information

Homologous gene family
HOM03P000359
(120 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P001946
(34 genes in 32 species)
specific family

Descriptions

gene_descr
ligase IV, DNA, ATP-dependent

Identifiers

Type Value
UniprotQ8BTF7
MGI1335098

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000012
ISO
IEA
Genome Projectsingle strand break repair
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0002328
IMP
Genome Projectpro-B cell differentiation
GO:0006260
IEA
Genome ProjectDNA replication
GO:0006266
IDA, IMP
ISO
IEA
Genome ProjectDNA ligation
GO:0006281
IMP
IEA
Genome ProjectDNA repair
GO:0006297
ISO, IBA
IEA
Genome Projectnucleotide-excision repair, DNA gap filling
GO:0006302
IMP, IGI
ISO
Genome Projectdouble-strand break repair
GO:0006303
IMP
ISO
IEA
Genome Projectdouble-strand break repair via nonhomologous end joining
GO:0006310
IEA
Genome ProjectDNA recombination
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007049
IEA
Genome Projectcell cycle
GO:0007417
IMP, IGI
Genome Projectcentral nervous system development
GO:0008283
IMP
Genome Projectcell proliferation
GO:0010165
ISO
IEA
Genome Projectresponse to X-ray
GO:0010212
IMP
Genome Projectresponse to ionizing radiation
GO:0010332
IMP
Genome Projectresponse to gamma radiation
GO:0033077
IMP
Genome ProjectT cell differentiation in thymus
GO:0033151
IDA, IMP
ISO
IEA
Genome ProjectV(D)J recombination
GO:0033152
IMP
Genome Projectimmunoglobulin V(D)J recombination
GO:0033153
IMP
Genome ProjectT cell receptor V(D)J recombination
GO:0035019
IMP
Genome Projectsomatic stem cell population maintenance
GO:0043524
IMP, IGI
Genome Projectnegative regulation of neuron apoptotic process
GO:0045190
IMP
Genome Projectisotype switching
GO:0048146
IMP
Genome Projectpositive regulation of fibroblast proliferation
GO:0050769
IMP
Genome Projectpositive regulation of neurogenesis
GO:0051102
IMP
Genome ProjectDNA ligation involved in DNA recombination
GO:0051103
IMP
ISO
IEA
Genome ProjectDNA ligation involved in DNA repair
GO:0051276
IGI
Genome Projectchromosome organization
GO:0051301
IEA
Genome Projectcell division
GO:0051402
IGI
Genome Projectneuron apoptotic process
GO:0071285
IEA
Genome Projectcellular response to lithium ion
GO:0071897
IEA
Genome ProjectDNA biosynthetic process
GO:0097680
ISO
IEA
Genome Projectdouble-strand break repair via classical nonhomologous end joining
GO:0006273
IBA
Genome Projectlagging strand elongation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003677
ISO
IEA
Genome ProjectDNA binding
GO:0003909
ISO
IEA
Genome ProjectDNA ligase activity
GO:0003910
IDA
ISO
IEA
Genome ProjectDNA ligase (ATP) activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IDA
IEA
Genome ProjectATP binding
GO:0008022
ISO
IEA
Genome Projectprotein C-terminus binding
GO:0016874
ISO
IEA
Genome Projectligase activity
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000793
ISO
IEA
Genome Projectcondensed chromosome
GO:0005634
ISO
IEA
Genome Projectnucleus
GO:0005654
ISO
IEA
Genome Projectnucleoplasm
GO:0005737
ISO, IBA
IEA
Genome Projectcytoplasm
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0005925
ISO
IEA
Genome Projectfocal adhesion
GO:0005958
IDA
ISO
Genome ProjectDNA-dependent protein kinase-DNA ligase 4 complex
GO:0032807
ISO, IBA
IEA
Genome ProjectDNA ligase IV complex
GO:0070419
ISS, ISO
IEA
Genome Projectnonhomologous end joining complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000977DNA ligase, ATP-dependent
IPR001357BRCT domain
IPR012308DNA ligase, ATP-dependent, N-terminal
IPR012309DNA ligase, ATP-dependent, C-terminal
IPR012310DNA ligase, ATP-dependent, central
IPR012340Nucleic acid-binding, OB-fold
IPR016059DNA ligase, ATP-dependent, conserved site
IPR021536DNA ligase IV domain
IPR029710DNA ligase 4

No MapMan annotations defined for this gene.