Gene: ENSMUSG00000049313 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000049313
Transcript Identifier
ENSMUST00000060989
Gene Type
Coding gene
Location
9 : 41968603-42124113 : negative

Family Information

Homologous gene family
HOM03P001101
(58 genes in 4 species)
specific family

Descriptions

gene_descr
sortilin-related receptor, LDLR class A repeats- containing

Identifiers

Type Value
UniprotO88307
MGI1202296

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000042
ISS, ISO
IEA
Genome Projectprotein targeting to Golgi
GO:0006605
ISS, ISO
IEA
Genome Projectprotein targeting
GO:0006622
ISS, ISO
IEA
Genome Projectprotein targeting to lysosome
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006810
IEA
Genome Projecttransport
GO:0006869
IEA
Genome Projectlipid transport
GO:0006892
ISS, ISO
IEA
Genome Projectpost-Golgi vesicle-mediated transport
GO:0006897
IEA
Genome Projectendocytosis
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008202
IEA
Genome Projectsteroid metabolic process
GO:0008203
IEA
Genome Projectcholesterol metabolic process
GO:0014910
ISO
IEA
Genome Projectregulation of smooth muscle cell migration
GO:0032091
ISS, ISO
IEA
Genome Projectnegative regulation of protein binding
GO:0032460
ISS, ISO
IEA
Genome Projectnegative regulation of protein oligomerization
GO:0043407
IMP
Genome Projectnegative regulation of MAP kinase activity
GO:0045053
IMP
ISO
IEA
Genome Projectprotein retention in Golgi apparatus
GO:0045732
ISS, ISO
IEA
Genome Projectpositive regulation of protein catabolic process
GO:0050768
IMP
Genome Projectnegative regulation of neurogenesis
GO:0051604
ISS, ISO
IEA
Genome Projectprotein maturation
GO:0070863
ISS, ISO
IEA
Genome Projectpositive regulation of protein exit from endoplasmic reticulum
GO:1901215
IMP
Genome Projectnegative regulation of neuron death
GO:1902430
IMP
ISO
IEA
Genome Projectnegative regulation of beta-amyloid formation
GO:1902771
IMP
Genome Projectpositive regulation of choline O-acetyltransferase activity
GO:1902948
IMP
Genome Projectnegative regulation of tau-protein kinase activity
GO:1902953
ISS, ISO
IEA
Genome Projectpositive regulation of ER to Golgi vesicle-mediated transport
GO:1902955
ISS, ISO
IEA
Genome Projectpositive regulation of early endosome to recycling endosome transport
GO:1902960
IMP
ISO
IEA
Genome Projectnegative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963
IMP
ISO
IEA
Genome Projectnegative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966
ISS, ISO
IEA
Genome Projectpositive regulation of protein localization to early endosome
GO:1902997
IMP
Genome Projectnegative regulation of neurofibrillary tangle assembly
GO:2001137
ISS, ISO
IEA
Genome Projectpositive regulation of endocytic recycling

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001540
ISO
IEA
Genome Projectbeta-amyloid binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0030169
ISO
IEA
Genome Projectlow-density lipoprotein particle binding
GO:0030306
ISO
IEA
Genome ProjectADP-ribosylation factor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
ISO
IEA
Genome Projectextracellular space
GO:0005641
IDA
ISO
IEA
Genome Projectnuclear envelope lumen
GO:0005768
ISO
IEA
Genome Projectendosome
GO:0005769
ISS, ISO
IEA
Genome Projectearly endosome
GO:0005783
ISS, ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005802
ISS, ISO
IEA
Genome Projecttrans-Golgi network
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0031985
ISS, ISO
IEA
Genome ProjectGolgi cisterna
GO:0034362
IEA
Genome Projectlow-density lipoprotein particle
GO:0048471
ISO
Genome Projectperinuclear region of cytoplasm
GO:0055037
ISS, ISO
IEA
Genome Projectrecycling endosome
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000033LDLR class B repeat
IPR002172Low-density lipoprotein (LDL) receptor class A repeat
IPR003961Fibronectin type III
IPR006581VPS10
IPR011042Six-bladed beta-propeller, TolB-like
IPR013783Immunoglobulin-like fold
IPR023415Low-density lipoprotein (LDL) receptor class A, conserved site
IPR031777Sortilin, C-terminal
IPR031778Sortilin, N-terminal

No MapMan annotations defined for this gene.