Gene: ENSMUSG00000045322 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000045322
Transcript Identifier
ENSMUST00000062241
Gene Type
Coding gene
Location
9 : 106222704-106226610 : positive

Family Information

Homologous gene family
HOM03P004593
(20 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P073623
(2 genes in 2 species)
specific family

Descriptions

gene_descr
toll-like receptor 9

Identifiers

Type Value
UniprotQ9EQU3
MGI1932389

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001932
IDA
Genome Projectregulation of protein phosphorylation
GO:0002237
TAS, IEA
Genome Projectresponse to molecule of bacterial origin
GO:0002376
IEA
Genome Projectimmune system process
GO:0002730
IDA
Genome Projectregulation of dendritic cell cytokine production
GO:0002755
IEA
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006955
IMP
Genome Projectimmune response
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007252
ISO
Genome ProjectI-kappaB phosphorylation
GO:0009615
IMP
Genome Projectresponse to virus
GO:0010628
ISO
Genome Projectpositive regulation of gene expression
GO:0030277
IMP
Genome Projectmaintenance of gastrointestinal epithelium
GO:0032088
ISO
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032640
ISO
Genome Projecttumor necrosis factor production
GO:0032715
IMP
Genome Projectnegative regulation of interleukin-6 production
GO:0032717
ISO
Genome Projectnegative regulation of interleukin-8 production
GO:0032722
ISO
Genome Projectpositive regulation of chemokine production
GO:0032725
ISO
Genome Projectpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032728
IDA
Genome Projectpositive regulation of interferon-beta production
GO:0032733
IDA
Genome Projectpositive regulation of interleukin-10 production
GO:0032735
IDA
Genome Projectpositive regulation of interleukin-12 production
GO:0032741
IDA
Genome Projectpositive regulation of interleukin-18 production
GO:0032755
IDA
ISO
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
ISO
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
IDA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0034122
ISO
Genome Projectnegative regulation of toll-like receptor signaling pathway
GO:0034123
ISO
Genome Projectpositive regulation of toll-like receptor signaling pathway
GO:0034162
IEA
Genome Projecttoll-like receptor 9 signaling pathway
GO:0042346
ISO
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0043123
ISO
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507
ISO
Genome Projectpositive regulation of JUN kinase activity
GO:0045078
ISS, ISO
Genome Projectpositive regulation of interferon-gamma biosynthetic process
GO:0045087
TAS, IEA
Genome Projectinnate immune response
GO:0045356
ISS, ISO
Genome Projectpositive regulation of interferon-alpha biosynthetic process
GO:0045359
ISS, ISO
Genome Projectpositive regulation of interferon-beta biosynthetic process
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050707
IEA
Genome Projectregulation of cytokine secretion
GO:0050727
IMP
Genome Projectregulation of inflammatory response
GO:0050729
IEA
Genome Projectpositive regulation of inflammatory response
GO:0050829
ISO
Genome Projectdefense response to Gram-negative bacterium
GO:0050864
IGI
Genome Projectregulation of B cell activation
GO:0051092
ISO
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051607
IGI
Genome Projectdefense response to virus
GO:0051770
IDA
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:1901895
ISO
Genome Projectnegative regulation of calcium-transporting ATPase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004888
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0005149
ISO
Genome Projectinterleukin-1 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0035197
ISS, ISO
Genome ProjectsiRNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISO
Genome Projectcytoplasm
GO:0005764
IDA
IEA
Genome Projectlysosome
GO:0005768
IDA
IEA
Genome Projectendosome
GO:0005783
IDA
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005886
IDA
ISS, ISO
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
ISO
Genome Projectbasolateral plasma membrane
GO:0016324
ISO
Genome Projectapical plasma membrane
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0032009
IDA
Genome Projectearly phagosome
GO:0045335
IEA
Genome Projectphagocytic vesicle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000157Toll/interleukin-1 receptor homology (TIR) domain
IPR001611Leucine-rich repeat
IPR003591Leucine-rich repeat, typical subtype
IPR027181Toll-like receptor 9

No MapMan annotations defined for this gene.