Gene: ENSMUSG00000044303 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000044303
Transcript Identifier
ENSMUST00000107131
Gene Type
Coding gene
Location
4 : 89276666-89294523 : negative

Family Information

Homologous gene family
HOM03P107326
(orphan gene)
specific family

Descriptions

gene_descr
cyclin-dependent kinase inhibitor 2A

Identifiers

Type Value
UniprotQ64364
MGI104738

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000079
IDA
Genome Projectregulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082
ISO
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000209
ISS, ISO
Genome Projectprotein polyubiquitination
GO:0000422
ISO
Genome Projectmitophagy
GO:0001953
ISO
Genome Projectnegative regulation of cell-matrix adhesion
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IDA
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006364
IEA
Genome ProjectrRNA processing
GO:0006469
ISO
Genome Projectnegative regulation of protein kinase activity
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006919
ISO
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049
IEA
Genome Projectcell cycle
GO:0007050
IDA
ISO
IEA
Genome Projectcell cycle arrest
GO:0007568
IMP
Genome Projectaging
GO:0007569
IDA
Genome Projectcell aging
GO:0008285
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008544
IMP
Genome Projectepidermis development
GO:0008637
ISO
Genome Projectapoptotic mitochondrial changes
GO:0009303
IGI
Genome ProjectrRNA transcription
GO:0010389
ISO
Genome Projectregulation of G2/M transition of mitotic cell cycle
GO:0010468
IMP
Genome Projectregulation of gene expression
GO:0030308
IMP
ISO
Genome Projectnegative regulation of cell growth
GO:0030889
IMP
Genome Projectnegative regulation of B cell proliferation
GO:0031647
IMP
Genome Projectregulation of protein stability
GO:0031648
ISO
Genome Projectprotein destabilization
GO:0032088
ISO
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032091
IDA
Genome Projectnegative regulation of protein binding
GO:0033088
IMP
Genome Projectnegative regulation of immature T cell proliferation in thymus
GO:0033235
ISO
Genome Projectpositive regulation of protein sumoylation
GO:0033600
IMP
Genome Projectnegative regulation of mammary gland epithelial cell proliferation
GO:0035019
IGI
Genome Projectsomatic stem cell population maintenance
GO:0035986
ISO
Genome Projectsenescence-associated heterochromatin focus assembly
GO:0042326
ISO
Genome Projectnegative regulation of phosphorylation
GO:0042593
IMP
Genome Projectglucose homeostasis
GO:0043065
ISS, ISO
Genome Projectpositive regulation of apoptotic process
GO:0043517
ISO
IC
Genome Projectpositive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045736
IDA
ISO
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786
IDA
Genome Projectnegative regulation of cell cycle
GO:0045892
ISO
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IMP
ISO
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
ISO
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046822
IGI
Genome Projectregulation of nucleocytoplasmic transport
GO:0046825
ISO
Genome Projectregulation of protein export from nucleus
GO:0048103
IMP
Genome Projectsomatic stem cell division
GO:0050821
ISO
Genome Projectprotein stabilization
GO:0051091
IMP
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051444
IDA
Genome Projectnegative regulation of ubiquitin-protein transferase activity
GO:0051882
ISO
Genome Projectmitochondrial depolarization
GO:0060058
IMP
Genome Projectpositive regulation of apoptotic process involved in mammary gland involution
GO:0070301
IDA
Genome Projectcellular response to hydrogen peroxide
GO:0070534
ISS, ISO
Genome Projectprotein K63-linked ubiquitination
GO:0071158
ISO
Genome Projectpositive regulation of cell cycle arrest
GO:0090398
IDA
ISO
Genome Projectcellular senescence
GO:0090399
ISO
Genome Projectreplicative senescence
GO:1900182
ISO
Genome Projectpositive regulation of protein localization to nucleus
GO:1901798
ISO
Genome Projectpositive regulation of signal transduction by p53 class mediator
GO:1902510
ISO
Genome Projectregulation of apoptotic DNA fragmentation
GO:1903051
IDA
ISO
Genome Projectnegative regulation of proteolysis involved in cellular protein catabolic process
GO:1903214
ISO
Genome Projectregulation of protein targeting to mitochondrion
GO:2000059
IDA
ISO
Genome Projectnegative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000774
ISO
Genome Projectpositive regulation of cellular senescence

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002039
ISO
Genome Projectp53 binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003700
IDA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0004861
IDA
ISO
Genome Projectcyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
ISO
Genome Projecttranscription factor binding
GO:0019901
ISO
Genome Projectprotein kinase binding
GO:0044822
ISO
Genome Projectpoly(A) RNA binding
GO:0047485
IPI
Genome Projectprotein N-terminus binding
GO:0051059
ISO
Genome ProjectNF-kappaB binding
GO:0055105
IDA
Genome Projectubiquitin-protein transferase inhibitor activity
GO:0097371
ISO
Genome ProjectMDM2/MDM4 family protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001652
IDA
Genome Projectgranular component
GO:0005634
ISO
IEA
Genome Projectnucleus
GO:0005654
IDA
ISO
IEA
Genome Projectnucleoplasm
GO:0005730
IDA
ISO
IEA
Genome Projectnucleolus
GO:0005737
IDA
ISO
Genome Projectcytoplasm
GO:0005739
ISO
IEA
Genome Projectmitochondrion
GO:0035985
ISO
Genome Projectsenescence-associated heterochromatin focus
GO:0043234
ISO
Genome Projectprotein complex
GO:0016604
ISO
Genome Projectnuclear body

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR010868Tumor suppressor ARF

No MapMan annotations defined for this gene.