Gene: ENSMUSG00000044254 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000044254
Transcript Identifier
ENSMUST00000049507
Gene Type
Coding gene
Location
4 : 106443346-106463910 : negative

Family Information

Homologous gene family
HOM03P000438
(104 genes in 26 species)
specific family
Orthologous gene family
ORTHO03P000588
(46 genes in 16 species)
specific family

Descriptions

gene_descr
proprotein convertase subtilisin/kexin type 9

Identifiers

Type Value
UniprotQ80W65
MGI2140260

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001822
IEP
IEA
Genome Projectkidney development
GO:0001889
IEP
IEA
Genome Projectliver development
GO:0001920
ISO
IEA
Genome Projectnegative regulation of receptor recycling
GO:0002092
ISO
IEA
Genome Projectpositive regulation of receptor internalization
GO:0006508
IEA
Genome Projectproteolysis
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006641
IDA
Genome Projecttriglyceride metabolic process
GO:0006644
IDA
Genome Projectphospholipid metabolic process
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007041
ISO
IEA
Genome Projectlysosomal transport
GO:0008202
IEA
Genome Projectsteroid metabolic process
GO:0008203
IDA
IEA
Genome Projectcholesterol metabolic process
GO:0009267
IDA
IEA
Genome Projectcellular response to starvation
GO:0010469
ISO
IEA
Genome Projectregulation of receptor activity
GO:0010989
ISO
IEA
Genome Projectnegative regulation of low-density lipoprotein particle clearance
GO:0016485
IEA
Genome Projectprotein processing
GO:0016540
ISS, ISO
IEA
Genome Projectprotein autoprocessing
GO:0022008
IEP
IEA
Genome Projectneurogenesis
GO:0030182
IDA, IMP
Genome Projectneuron differentiation
GO:0032799
IDA
Genome Projectlow-density lipoprotein receptor particle metabolic process
GO:0032802
ISS, ISO
IEA
Genome Projectlow-density lipoprotein particle receptor catabolic process
GO:0032803
IMP
Genome Projectregulation of low-density lipoprotein particle receptor catabolic process
GO:0032805
ISO
IEA
Genome Projectpositive regulation of low-density lipoprotein particle receptor catabolic process
GO:0032869
IDA
IEA
Genome Projectcellular response to insulin stimulus
GO:0042157
IDA
Genome Projectlipoprotein metabolic process
GO:0042632
ISS, ISO
IEA
Genome Projectcholesterol homeostasis
GO:0043523
IMP
Genome Projectregulation of neuron apoptotic process
GO:0043525
ISS, ISO
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:2000272
ISO
IEA
Genome Projectnegative regulation of receptor activity
GO:2000650
ISO
Genome Projectnegative regulation of sodium ion transmembrane transporter activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004252
ISS, ISO, IBA
IEA
Genome Projectserine-type endopeptidase activity
GO:0005102
ISO
Genome Projectreceptor binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0008236
IEA
Genome Projectserine-type peptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0019871
ISO
IEA
Genome Projectsodium channel inhibitor activity
GO:0030169
IDA
Genome Projectlow-density lipoprotein particle binding
GO:0030547
ISO
IEA
Genome Projectreceptor inhibitor activity
GO:0034185
IDA
Genome Projectapolipoprotein binding
GO:0034189
IDA
Genome Projectvery-low-density lipoprotein particle binding
GO:0034190
ISO
IEA
Genome Projectapolipoprotein receptor binding
GO:0043621
ISS, ISO
IEA
Genome Projectprotein self-association
GO:0044822
ISO
IEA
Genome Projectpoly(A) RNA binding
GO:0050750
IDA
ISO
IEA
Genome Projectlow-density lipoprotein particle receptor binding
GO:0070326
ISO
IEA
Genome Projectvery-low-density lipoprotein particle receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
IEA
Genome Projectextracellular region
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0005737
ISS, ISO
IEA
Genome Projectcytoplasm
GO:0005764
ISS, ISO
IEA
Genome Projectlysosome
GO:0005768
IEA
Genome Projectendosome
GO:0005769
ISS, ISO
IEA
Genome Projectearly endosome
GO:0005770
ISS, ISO
IEA
Genome Projectlate endosome
GO:0005783
IDA
ISS, ISO
IEA
Genome Projectendoplasmic reticulum
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0005791
IEA
Genome Projectrough endoplasmic reticulum
GO:0005794
ISS, ISO
IEA
Genome ProjectGolgi apparatus
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0009986
ISS, ISO
IEA
Genome Projectcell surface
GO:0030134
IDA
Genome ProjectER to Golgi transport vesicle
GO:0048471
ISO
IEA
Genome Projectperinuclear region of cytoplasm
GO:1990666
ISS, ISO
Genome ProjectPCSK9-LDLR complex
GO:1990667
ISS, ISO
Genome ProjectPCSK9-AnxA2 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000209Peptidase S8/S53 domain
IPR009020Proteinase inhibitor, propeptide
IPR010259Peptidase S8 propeptide/proteinase inhibitor I9
IPR015500Peptidase S8, subtilisin-related

No MapMan annotations defined for this gene.