Gene: ENSMUSG00000042258 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000042258
Transcript Identifier
ENSMUST00000036060
Gene Type
Coding gene
Location
13 : 116299480-116309422 : negative

Family Information

Homologous gene family
HOM03P001943
(42 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P015371
(6 genes in 4 species)
specific family

Descriptions

gene_descr
ISL1 transcription factor, LIM/homeodomain

Identifiers

Type Value
UniprotP61372
UniprotA2RSV5
MGI101791

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001755
IGI
Genome Projectneural crest cell migration
GO:0003007
IGI
Genome Projectheart morphogenesis
GO:0003139
ISO
IEA
Genome Projectsecondary heart field specification
GO:0003266
IMP
Genome Projectregulation of secondary heart field cardioblast proliferation
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0007507
IMP
Genome Projectheart development
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0010468
IMP
Genome Projectregulation of gene expression
GO:0021520
IGI
Genome Projectspinal cord motor neuron cell fate specification
GO:0021522
IMP
Genome Projectspinal cord motor neuron differentiation
GO:0021524
IGI
Genome Projectvisceral motor neuron differentiation
GO:0021983
IMP
Genome Projectpituitary gland development
GO:0030182
IMP, IGI
Genome Projectneuron differentiation
GO:0031016
IMP
Genome Projectpancreas development
GO:0031103
IEA
Genome Projectaxon regeneration
GO:0031290
IMP
Genome Projectretinal ganglion cell axon guidance
GO:0032024
IEA
Genome Projectpositive regulation of insulin secretion
GO:0033147
IEA
Genome Projectnegative regulation of intracellular estrogen receptor signaling pathway
GO:0042517
IDA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043388
IDA
Genome Projectpositive regulation of DNA binding
GO:0045665
IGI
Genome Projectnegative regulation of neuron differentiation
GO:0045944
IDA, IMP, IGI
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048663
IGI
Genome Projectneuron fate commitment
GO:0048762
IMP
Genome Projectmesenchymal cell differentiation
GO:0048935
IGI
Genome Projectperipheral nervous system neuron development
GO:0060379
IMP
Genome Projectcardiac muscle cell myoblast differentiation
GO:0060913
IMP
ISO
IEA
Genome Projectcardiac cell fate determination
GO:0071385
IEA
Genome Projectcellular response to glucocorticoid stimulus
GO:0090074
IEA
Genome Projectnegative regulation of protein homodimerization activity
GO:0090090
IGI
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0003148
IGI
Genome Projectoutflow tract septum morphogenesis
GO:0003151
IGI
Genome Projectoutflow tract morphogenesis
GO:0003203
IGI
Genome Projectendocardial cushion morphogenesis
GO:0003215
IGI
Genome Projectcardiac right ventricle morphogenesis
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0010575
IDA
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0021559
IMP
Genome Projecttrigeminal nerve development
GO:0032725
IDA
Genome Projectpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729
IDA
Genome Projectpositive regulation of interferon-gamma production
GO:0032730
IDA
Genome Projectpositive regulation of interleukin-1 alpha production
GO:0032731
IDA
Genome Projectpositive regulation of interleukin-1 beta production
GO:0032735
IDA
Genome Projectpositive regulation of interleukin-12 production
GO:0032755
IDA
Genome Projectpositive regulation of interleukin-6 production
GO:0032760
IDA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0035066
IMP
Genome Projectpositive regulation of histone acetylation
GO:0043524
IMP
Genome Projectnegative regulation of neuron apoptotic process
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0045892
ISS
Genome Projectnegative regulation of transcription, DNA-templated
GO:0048665
IMP
Genome Projectneuron fate specification
GO:0048880
IMP
Genome Projectsensory system development
GO:0048936
IMP
Genome Projectperipheral nervous system neuron axonogenesis
GO:0050728
IMP
Genome Projectnegative regulation of inflammatory response
GO:0055010
IGI
Genome Projectventricular cardiac muscle tissue morphogenesis
GO:0060037
IGI
Genome Projectpharyngeal system development
GO:0060384
IMP
Genome Projectinnervation
GO:0060413
IGI
Genome Projectatrial septum morphogenesis
GO:0071657
IDA
Genome Projectpositive regulation of granulocyte colony-stimulating factor production
GO:1901258
IDA
Genome Projectpositive regulation of macrophage colony-stimulating factor production

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000978
IEA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102
ISO
IEA
Genome ProjectRNA polymerase II activating transcription factor binding
GO:0001105
IDA
ISO
IEA
Genome ProjectRNA polymerase II transcription coactivator activity
GO:0001158
ISO
IEA
Genome Projectenhancer sequence-specific DNA binding
GO:0003677
IDA
IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016922
IEA
Genome Projectligand-dependent nuclear receptor binding
GO:0030331
IEA
Genome Projectestrogen receptor binding
GO:0043425
ISO
IEA
Genome ProjectbHLH transcription factor binding
GO:0043565
IEA
Genome Projectsequence-specific DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
ISO
IEA
Genome Projectnucleoplasm
GO:0005739
ISO
IEA
Genome Projectmitochondrion

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001356Homeobox domain
IPR001781Zinc finger, LIM-type
IPR009057Homeodomain-like
IPR017970Homeobox, conserved site

No MapMan annotations defined for this gene.