Gene: ENSMUSG00000042228 (Mus musculus)

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Gene Identifier
ENSMUSG00000042228
Transcript Identifier
ENSMUST00000041377
Gene Type
Coding gene
Location
4 : 3738730-3789944 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P005517
(15 genes in 3 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

Identifiers

Type Value
UniprotP25911
UniprotQ3TCS3
MGI96892

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001782
IMP
Genome ProjectB cell homeostasis
GO:0001817
IMP
Genome Projectregulation of cytokine production
GO:0001933
IMP
Genome Projectnegative regulation of protein phosphorylation
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002431
IMP
Genome ProjectFc receptor mediated stimulatory signaling pathway
GO:0002513
IMP
Genome Projecttolerance induction to self antigen
GO:0002553
IEA
Genome Projecthistamine secretion by mast cell
GO:0002576
IMP
Genome Projectplatelet degranulation
GO:0002762
IMP
Genome Projectnegative regulation of myeloid leukocyte differentiation
GO:0002768
IMP
Genome Projectimmune response-regulating cell surface receptor signaling pathway
GO:0002774
IMP
Genome ProjectFc receptor mediated inhibitory signaling pathway
GO:0002902
IMP
Genome Projectregulation of B cell apoptotic process
GO:0006468
ISO
IEA
Genome Projectprotein phosphorylation
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006974
ISO, IBA
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0006991
IEA
Genome Projectresponse to sterol depletion
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007169
ISO, IBA
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0008285
IMP
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009636
IEA
Genome Projectresponse to toxic substance
GO:0009725
IDA
Genome Projectresponse to hormone
GO:0009743
IEA
Genome Projectresponse to carbohydrate
GO:0010976
ISO
IEA
Genome Projectpositive regulation of neuron projection development
GO:0014003
IEA
Genome Projectoligodendrocyte development
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
ISO
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030097
IMP
Genome Projecthemopoiesis
GO:0030218
IMP
Genome Projecterythrocyte differentiation
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0030889
IMP
Genome Projectnegative regulation of B cell proliferation
GO:0031175
IMP
Genome Projectneuron projection development
GO:0031663
IMP
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0031668
IEA
Genome Projectcellular response to extracellular stimulus
GO:0032868
IEA
Genome Projectresponse to insulin
GO:0033003
IMP
Genome Projectregulation of mast cell activation
GO:0033628
ISO
IEA
Genome Projectregulation of cell adhesion mediated by integrin
GO:0034136
IMP
Genome Projectnegative regulation of toll-like receptor 2 signaling pathway
GO:0034144
IMP
Genome Projectnegative regulation of toll-like receptor 4 signaling pathway
GO:0034605
IEA
Genome Projectcellular response to heat
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042327
IEA
Genome Projectpositive regulation of phosphorylation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042531
IMP
Genome Projectpositive regulation of tyrosine phosphorylation of STAT protein
GO:0042541
TAS
Genome Projecthemoglobin biosynthetic process
GO:0043200
IEA
Genome Projectresponse to amino acid
GO:0043304
IMP
Genome Projectregulation of mast cell degranulation
GO:0043407
IMP
Genome Projectnegative regulation of MAP kinase activity
GO:0043434
IEA
Genome Projectresponse to peptide hormone
GO:0043552
IMP
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0045087
IBA
IEA
Genome Projectinnate immune response
GO:0045646
IMP
Genome Projectregulation of erythrocyte differentiation
GO:0046777
IDA
ISO
TAS, IEA
Genome Projectprotein autophosphorylation
GO:0048678
IEA
Genome Projectresponse to axon injury
GO:0050663
IEA
Genome Projectcytokine secretion
GO:0050707
IMP
Genome Projectregulation of cytokine secretion
GO:0050727
IMP
Genome Projectregulation of inflammatory response
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050853
IDA
Genome ProjectB cell receptor signaling pathway
GO:0050855
IMP
Genome Projectregulation of B cell receptor signaling pathway
GO:0050861
IGI
Genome Projectpositive regulation of B cell receptor signaling pathway
GO:0051272
ISO
IEA
Genome Projectpositive regulation of cellular component movement
GO:0051279
IGI
IEA
Genome Projectregulation of release of sequestered calcium ion into cytosol
GO:0060252
IEA
Genome Projectpositive regulation of glial cell proliferation
GO:0060369
IEA
Genome Projectpositive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0070304
ISO
IEA
Genome Projectpositive regulation of stress-activated protein kinase signaling cascade
GO:0070372
IMP
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0070373
IMP
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070447
IEA
Genome Projectpositive regulation of oligodendrocyte progenitor proliferation
GO:0070667
IMP
Genome Projectnegative regulation of mast cell proliferation
GO:0070668
ISO
IEA
Genome Projectpositive regulation of mast cell proliferation
GO:0071300
ISO
IEA
Genome Projectcellular response to retinoic acid
GO:0071375
IBA
Genome Projectcellular response to peptide hormone stimulus
GO:0090025
ISO
IEA
Genome Projectregulation of monocyte chemotaxis
GO:0090330
IMP
Genome Projectregulation of platelet aggregation
GO:0097028
IMP
Genome Projectdendritic cell differentiation
GO:1902532
IMP
Genome Projectnegative regulation of intracellular signal transduction
GO:2000670
IMP
Genome Projectpositive regulation of dendritic cell apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
IEA
Genome Projectprotein kinase activity
GO:0004713
IDA
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IBA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005128
TAS
Genome Projecterythropoietin receptor binding
GO:0005161
IEA
Genome Projectplatelet-derived growth factor receptor binding
GO:0005178
IEA
Genome Projectintegrin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0017124
IPI
Genome ProjectSH3 domain binding
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0031625
IEA
Genome Projectubiquitin protein ligase binding
GO:0032403
IPI
IEA
Genome Projectprotein complex binding
GO:0043015
IEA
Genome Projectgamma-tubulin binding
GO:0043208
IEA
Genome Projectglycosphingolipid binding
GO:0044325
ISO
IEA
Genome Projection channel binding
GO:0051219
IEA
Genome Projectphosphoprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005758
IEA
Genome Projectmitochondrial intermembrane space
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IDA
ISO
IEA
Genome Projectplasma membrane
GO:0005913
IEA
Genome Projectcell-cell adherens junction
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0030061
IEA
Genome Projectmitochondrial crista
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0031966
IEA
Genome Projectmitochondrial membrane
GO:0034666
IEA
Genome Projectintegrin alpha2-beta1 complex
GO:0042629
IEA
Genome Projectmast cell granule
GO:0045121
ISO
IEA
Genome Projectmembrane raft
GO:0048471
ISO
IEA
Genome Projectperinuclear region of cytoplasm
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452SH3 domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.