Gene: ENSMUSG00000041417 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000041417
Transcript Identifier
ENSMUST00000055518
Gene Type
Coding gene
Location
13 : 101684880-101757659 : negative

Family Information

Homologous gene family
HOM03P008093
(10 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P010275
(8 genes in 4 species)
specific family

Descriptions

gene_descr
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)

Identifiers

Type Value
UniprotP26450
MGI97583

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001678
IDA
Genome Projectcellular glucose homeostasis
GO:0001953
IGI
Genome Projectnegative regulation of cell-matrix adhesion
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0006810
IEA
Genome Projecttransport
GO:0007162
IDA
Genome Projectnegative regulation of cell adhesion
GO:0007165
IEA
Genome Projectsignal transduction
GO:0008286
ISS, IBA
Genome Projectinsulin receptor signaling pathway
GO:0008625
IMP, IGI
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0008630
IMP, IGI
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0014065
ISO
IEA
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0015031
IEA
Genome Projectprotein transport
GO:0030183
IMP
Genome ProjectB cell differentiation
GO:0030335
IGI
Genome Projectpositive regulation of cell migration
GO:0032760
IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032869
IDA
Genome Projectcellular response to insulin stimulus
GO:0033120
ISS, ISO
IEA
Genome Projectpositive regulation of RNA splicing
GO:0034644
IMP, IGI
Genome Projectcellular response to UV
GO:0034976
IDA
ISO
Genome Projectresponse to endoplasmic reticulum stress
GO:0036092
TAS
Genome Projectphosphatidylinositol-3-phosphate biosynthetic process
GO:0042993
IMP
ISS, ISO
Genome Projectpositive regulation of transcription factor import into nucleus
GO:0043066
IDA
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043551
IBA
Genome Projectregulation of phosphatidylinositol 3-kinase activity
GO:0045671
IGI
Genome Projectnegative regulation of osteoclast differentiation
GO:0045944
IDA, IMP
ISO
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046854
ISS
Genome Projectphosphatidylinositol phosphorylation
GO:0048009
ISS, ISO
IEA
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0050821
ISS, ISO
IEA
Genome Projectprotein stabilization
GO:0051492
IMP
Genome Projectregulation of stress fiber assembly
GO:0051531
IMP
Genome ProjectNFAT protein import into nucleus
GO:0060396
ISO
IEA
Genome Projectgrowth hormone receptor signaling pathway
GO:0090003
IDA
Genome Projectregulation of establishment of protein localization to plasma membrane
GO:1900103
ISS, ISO
IEA
Genome Projectpositive regulation of endoplasmic reticulum unfolded protein response
GO:2001275
ISS
Genome Projectpositive regulation of glucose import in response to insulin stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005158
ISS, ISO
IEA
Genome Projectinsulin receptor binding
GO:0005159
ISS, ISO
IEA
Genome Projectinsulin-like growth factor receptor binding
GO:0005168
ISO
IEA
Genome Projectneurotrophin TRKA receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
ISO
IEA
Genome Projecttranscription factor binding
GO:0016303
TAS
Genome Project1-phosphatidylinositol-3-kinase activity
GO:0019903
ISO
IEA
Genome Projectprotein phosphatase binding
GO:0035014
ISS
IEA
Genome Projectphosphatidylinositol 3-kinase regulator activity
GO:0036312
IPI
Genome Projectphosphatidylinositol 3-kinase regulatory subunit binding
GO:0043125
ISS, ISO
IEA
Genome ProjectErbB-3 class receptor binding
GO:0043559
ISO
IEA
Genome Projectinsulin binding
GO:0043560
IPI
Genome Projectinsulin receptor substrate binding
GO:0046935
IBA
Genome Project1-phosphatidylinositol-3-kinase regulator activity
GO:0046982
IPI
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
Genome Projectnucleus
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005801
IDA
Genome Projectcis-Golgi network
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005911
IDA
Genome Projectcell-cell junction
GO:0005942
TAS, IEA
Genome Projectphosphatidylinositol 3-kinase complex
GO:0005943
ISS
Genome Projectphosphatidylinositol 3-kinase complex, class IA
GO:0016020
IDA
ISO
IEA
Genome Projectmembrane
GO:1990578
IDA
Genome Projectperinuclear endoplasmic reticulum membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000198Rho GTPase-activating protein domain
IPR000980SH2 domain
IPR001452SH3 domain
IPR001720PI3K p85 subunit
IPR008936Rho GTPase activation protein
IPR032498PI3K p85 subunit, inter-SH2 domain

No MapMan annotations defined for this gene.