Gene: ENSMUSG00000041301 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000041301
Transcript Identifier
ENSMUST00000045706
Gene Type
Coding gene
Location
6 : 18170824-18321033 : positive

Family Information

Homologous gene family
HOM03P000020
(1002 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P067331
(2 genes in 2 species)
specific family

Descriptions

gene_descr
cystic fibrosis transmembrane conductance regulator

Identifiers

Type Value
UniprotP26361
MGI88388

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006695
IMP
Genome Projectcholesterol biosynthetic process
GO:0006810
IEA
Genome Projecttransport
GO:0006811
IEA
Genome Projection transport
GO:0006821
IGI
IEA
Genome Projectchloride transport
GO:0006904
IMP
Genome Projectvesicle docking involved in exocytosis
GO:0015701
IMP
Genome Projectbicarbonate transport
GO:0030301
IMP
Genome Projectcholesterol transport
GO:0035774
IMP
ISO
Genome Projectpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045921
IMP
ISO
Genome Projectpositive regulation of exocytosis
GO:0048240
IMP
Genome Projectsperm capacitation
GO:0051454
IMP
Genome Projectintracellular pH elevation
GO:0055085
IEA
Genome Projecttransmembrane transport
GO:0060081
IMP
Genome Projectmembrane hyperpolarization
GO:0071320
IDA
Genome Projectcellular response to cAMP
GO:1902161
IMP
ISO
Genome Projectpositive regulation of cyclic nucleotide-gated ion channel activity
GO:1902476
IMP
ISO
Genome Projectchloride transmembrane transport
GO:1902943
ISO
IEA
Genome Projectpositive regulation of voltage-gated chloride channel activity
GO:0003254
IMP
Genome Projectregulation of membrane depolarization

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0005254
IMP
ISS, ISO
IEA
Genome Projectchloride channel activity
GO:0005260
IEA
Genome Projectchannel-conductance-controlling ATPase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0015106
IMP
Genome Projectbicarbonate transmembrane transporter activity
GO:0015108
IMP
Genome Projectchloride transmembrane transporter activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0016887
IEA
Genome ProjectATPase activity
GO:0019869
ISS, ISO
IEA
Genome Projectchloride channel inhibitor activity
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0030165
ISO
IEA
Genome ProjectPDZ domain binding
GO:0042626
IEA
Genome ProjectATPase activity, coupled to transmembrane movement of substances

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005768
IEA
Genome Projectendosome
GO:0005769
ISS, ISO
IEA
Genome Projectearly endosome
GO:0005829
IDA
ISO
Genome Projectcytosol
GO:0005886
IDA
ISS, ISO
IEA
Genome Projectplasma membrane
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016324
ISO
IEA
Genome Projectapical plasma membrane
GO:0031205
ISO
IEA
Genome Projectendoplasmic reticulum Sec complex
GO:0031901
IEA
Genome Projectearly endosome membrane
GO:0034707
IEA
Genome Projectchloride channel complex
GO:0043234
ISO
IEA
Genome Projectprotein complex
GO:0055037
ISO
IEA
Genome Projectrecycling endosome
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003439ABC transporter-like
IPR003593AAA+ ATPase domain
IPR009147Cystic fibrosis transmembrane conductance regulator
IPR011527ABC transporter type 1, transmembrane domain
IPR017871ABC transporter, conserved site
IPR025837CFTR regulator domain
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.