Gene: ENSMUSG00000041135 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000041135
Transcript Identifier
ENSMUST00000037035
Gene Type
Coding gene
Location
4 : 16123554-16163396 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P070279
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
receptor (TNFRSF)-interacting serine-threonine kinase 2

Identifiers

Type Value
UniprotP58801
UniprotQ547H1
MGI1891456

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001961
IMP
Genome Projectpositive regulation of cytokine-mediated signaling pathway
GO:0002250
IMP
IEA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002827
IMP
Genome Projectpositive regulation of T-helper 1 type immune response
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007249
IMP
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0010800
ISS, ISO
IEA
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0031398
ISO
IEA
Genome Projectpositive regulation of protein ubiquitination
GO:0031663
IMP
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032722
IMP
Genome Projectpositive regulation of chemokine production
GO:0032729
IMP
Genome Projectpositive regulation of interferon-gamma production
GO:0032743
IMP
Genome Projectpositive regulation of interleukin-2 production
GO:0032755
IMP
Genome Projectpositive regulation of interleukin-6 production
GO:0032760
IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032874
IMP
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0033091
IMP
Genome Projectpositive regulation of immature T cell proliferation
GO:0033138
ISS, ISO
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034134
ISO
IEA
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034142
IMP
Genome Projecttoll-like receptor 4 signaling pathway
GO:0042098
IMP
Genome ProjectT cell proliferation
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043065
IDA
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043123
IMP
ISO
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330
IMP
Genome Projectresponse to exogenous dsRNA
GO:0045087
IMP
ISO
IEA
Genome Projectinnate immune response
GO:0045627
IMP
Genome Projectpositive regulation of T-helper 1 cell differentiation
GO:0046330
IMP
Genome Projectpositive regulation of JNK cascade
GO:0046641
IMP
Genome Projectpositive regulation of alpha-beta T cell proliferation
GO:0050731
ISS, ISO
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050830
IMP
Genome Projectdefense response to Gram-positive bacterium
GO:0050852
IMP
Genome ProjectT cell receptor signaling pathway
GO:0051092
IMP
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0070374
IDA, IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070427
IMP
Genome Projectnucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431
IMP
ISO
IEA
Genome Projectnucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070555
IMP
Genome Projectresponse to interleukin-1
GO:0070671
IMP
Genome Projectresponse to interleukin-12
GO:0070673
IMP
Genome Projectresponse to interleukin-18
GO:0071222
IMP
Genome Projectcellular response to lipopolysaccharide
GO:0071223
IMP
Genome Projectcellular response to lipoteichoic acid
GO:0071224
IMP
Genome Projectcellular response to peptidoglycan
GO:0071225
ISS, ISO
IEA
Genome Projectcellular response to muramyl dipeptide
GO:0043281
IMP
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004715
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005102
ISO
Genome Projectreceptor binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0030274
ISO
IEA
Genome ProjectLIM domain binding
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0050700
ISO
IEA
Genome ProjectCARD domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISS, ISO
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
ISS, ISO
IEA
Genome Projectcytoskeleton
GO:0031982
ISS, ISO
IEA
Genome Projectvesicle
GO:0043234
ISS, ISO
IEA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001315CARD domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011029Death-like domain
IPR017322Receptor-interacting serine/threonine-protein kinase 2

No MapMan annotations defined for this gene.