Gene: ENSMUSG00000040152 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000040152
Transcript Identifier
ENSMUST00000039559
Gene Type
Coding gene
Location
2 : 118112643-118125029 : positive

Family Information

Homologous gene family
HOM03P008890
(9 genes in 4 species)
specific family

Descriptions

gene_descr
thrombospondin 1

Identifiers

Type Value
UniprotQ80YQ1
MGI98737

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
ISO
IEA
Genome Projectactivation of MAPK activity
GO:0001937
IMP
ISO
IEA
Genome Projectnegative regulation of endothelial cell proliferation
GO:0001953
ISO
IEA
Genome Projectnegative regulation of cell-matrix adhesion
GO:0002040
ISO
IEA
Genome Projectsprouting angiogenesis
GO:0002544
IEA
Genome Projectchronic inflammatory response
GO:0002581
ISO
IEA
Genome Projectnegative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605
ISO
IEA
Genome Projectnegative regulation of dendritic cell antigen processing and presentation
GO:0003151
IGI
Genome Projectoutflow tract morphogenesis
GO:0003197
IGI
Genome Projectendocardial cushion development
GO:0003417
IMP, IGI
Genome Projectgrowth plate cartilage development
GO:0006954
IMP
ISO
IEA
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0007050
ISO
IEA
Genome Projectcell cycle arrest
GO:0007155
IEA
Genome Projectcell adhesion
GO:0009749
ISO
IEA
Genome Projectresponse to glucose
GO:0010595
ISO
IEA
Genome Projectpositive regulation of endothelial cell migration
GO:0010596
ISO
IEA
Genome Projectnegative regulation of endothelial cell migration
GO:0010748
ISO
IEA
Genome Projectnegative regulation of plasma membrane long-chain fatty acid transport
GO:0010751
ISO
IEA
Genome Projectnegative regulation of nitric oxide mediated signal transduction
GO:0010754
ISO
IEA
Genome Projectnegative regulation of cGMP-mediated signaling
GO:0010757
ISO
IEA
Genome Projectnegative regulation of plasminogen activation
GO:0010763
ISO
IEA
Genome Projectpositive regulation of fibroblast migration
GO:0010811
IDA
Genome Projectpositive regulation of cell-substrate adhesion
GO:0016477
ISO
IEA
Genome Projectcell migration
GO:0016525
IDA, IMP
ISO
IEA
Genome Projectnegative regulation of angiogenesis
GO:0018149
ISO
IEA
Genome Projectpeptide cross-linking
GO:0030194
ISO
IEA
Genome Projectpositive regulation of blood coagulation
GO:0030335
ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0030511
ISO
IEA
Genome Projectpositive regulation of transforming growth factor beta receptor signaling pathway
GO:0030823
ISO
IEA
Genome Projectregulation of cGMP metabolic process
GO:0032026
ISO
IEA
Genome Projectresponse to magnesium ion
GO:0032695
ISO
IEA
Genome Projectnegative regulation of interleukin-12 production
GO:0040037
ISO
IEA
Genome Projectnegative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327
ISO
IEA
Genome Projectpositive regulation of phosphorylation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042535
ISO
IEA
Genome Projectpositive regulation of tumor necrosis factor biosynthetic process
GO:0043032
ISO
IEA
Genome Projectpositive regulation of macrophage activation
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043154
ISO
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536
ISO
IEA
Genome Projectpositive regulation of blood vessel endothelial cell migration
GO:0043537
ISO
IEA
Genome Projectnegative regulation of blood vessel endothelial cell migration
GO:0043652
ISO
IEA
Genome Projectengulfment of apoptotic cell
GO:0045727
ISO
IEA
Genome Projectpositive regulation of translation
GO:0045766
ISO
IEA
Genome Projectpositive regulation of angiogenesis
GO:0048514
IGI
Genome Projectblood vessel morphogenesis
GO:0050921
ISO
IEA
Genome Projectpositive regulation of chemotaxis
GO:0051592
ISO
IEA
Genome Projectresponse to calcium ion
GO:0051897
ISO
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051918
ISO
IEA
Genome Projectnegative regulation of fibrinolysis
GO:0071732
IMP
Genome Projectcellular response to nitric oxide
GO:1902043
ISO
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000353
ISO
IEA
Genome Projectpositive regulation of endothelial cell apoptotic process
GO:2000379
ISO
IEA
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2001027
ISO
IEA
Genome Projectnegative regulation of endothelial cell chemotaxis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001786
ISO
IEA
Genome Projectphosphatidylserine binding
GO:0001968
ISO
IEA
Genome Projectfibronectin binding
GO:0005178
ISO
IEA
Genome Projectintegrin binding
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0008201
ISO
IEA
Genome Projectheparin binding
GO:0017134
ISO
IEA
Genome Projectfibroblast growth factor binding
GO:0030169
ISO
IEA
Genome Projectlow-density lipoprotein particle binding
GO:0043236
ISO
IEA
Genome Projectlaminin binding
GO:0050840
IDA
IEA
Genome Projectextracellular matrix binding
GO:0070051
ISO
IEA
Genome Projectfibrinogen binding
GO:0070052
ISO
IEA
Genome Projectcollagen V binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005577
ISO
IEA
Genome Projectfibrinogen complex
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0009897
ISO
IEA
Genome Projectexternal side of plasma membrane
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0030141
ISO
IEA
Genome Projectsecretory granule
GO:0031012
ISO
IEA
Genome Projectextracellular matrix
GO:0031091
ISO
IEA
Genome Projectplatelet alpha granule
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000742EGF-like domain
IPR000884Thrombospondin type-1 (TSP1) repeat
IPR001007VWFC domain
IPR001791Laminin G domain
IPR003367Thrombospondin, type 3-like repeat
IPR008859Thrombospondin, C-terminal
IPR013032EGF-like, conserved site
IPR013320Concanavalin A-like lectin/glucanase domain
IPR017897Thrombospondin, type 3 repeat
IPR028499Thrombospondin-1
IPR028974TSP type-3 repeat

No MapMan annotations defined for this gene.