Gene: ENSMUSG00000039239 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000039239
Transcript Identifier
ENSMUST00000195201
Gene Type
Coding gene
Location
1 : 186625448-186704774 : negative

Family Information

Homologous gene family
HOM03P019048
(4 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P074175
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
transforming growth factor, beta 2

Identifiers

Type Value
UniprotA0A0A6YXU9
MGI98726

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000902
ISO
Genome Projectcell morphogenesis
GO:0001501
IMP
Genome Projectskeletal system development
GO:0001502
IGI
Genome Projectcartilage condensation
GO:0001568
IMP
Genome Projectblood vessel development
GO:0001654
ISO
Genome Projecteye development
GO:0001666
ISO
Genome Projectresponse to hypoxia
GO:0001837
ISO
Genome Projectepithelial to mesenchymal transition
GO:0001942
IMP
ISO
Genome Projecthair follicle development
GO:0001974
IMP
Genome Projectblood vessel remodeling
GO:0003007
ISO
Genome Projectheart morphogenesis
GO:0003179
IMP
Genome Projectheart valve morphogenesis
GO:0006468
ISO
Genome Projectprotein phosphorylation
GO:0007050
ISO
Genome Projectcell cycle arrest
GO:0007179
ISO, IBA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007184
ISO
Genome ProjectSMAD protein import into nucleus
GO:0007411
IMP
Genome Projectaxon guidance
GO:0007507
IMP
ISO
Genome Projectheart development
GO:0008219
ISO
Genome Projectcell death
GO:0008284
ISO
Genome Projectpositive regulation of cell proliferation
GO:0008285
ISO
Genome Projectnegative regulation of cell proliferation
GO:0008347
ISO
Genome Projectglial cell migration
GO:0010002
ISO
Genome Projectcardioblast differentiation
GO:0010634
ISO
Genome Projectpositive regulation of epithelial cell migration
GO:0010693
ISO
Genome Projectnegative regulation of alkaline phosphatase activity
GO:0010718
ISO
Genome Projectpositive regulation of epithelial to mesenchymal transition
GO:0010862
IBA
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936
ISO
Genome Projectnegative regulation of macrophage cytokine production
GO:0014068
ISO
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016049
IEA
Genome Projectcell growth
GO:0016477
ISO
Genome Projectcell migration
GO:0023014
ISO
Genome Projectsignal transduction by protein phosphorylation
GO:0030198
IMP
Genome Projectextracellular matrix organization
GO:0030199
ISO
Genome Projectcollagen fibril organization
GO:0030307
ISO
Genome Projectpositive regulation of cell growth
GO:0030308
ISO
Genome Projectnegative regulation of cell growth
GO:0032147
ISO
Genome Projectactivation of protein kinase activity
GO:0032570
ISO
Genome Projectresponse to progesterone
GO:0032874
ISO
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0032909
ISO
Genome Projectregulation of transforming growth factor beta2 production
GO:0033630
ISO
Genome Projectpositive regulation of cell adhesion mediated by integrin
GO:0040007
IEA
Genome Projectgrowth
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0042493
ISO
Genome Projectresponse to drug
GO:0042981
IMP
Genome Projectregulation of apoptotic process
GO:0043408
IBA
Genome Projectregulation of MAPK cascade
GO:0043525
ISO
Genome Projectpositive regulation of neuron apoptotic process
GO:0045216
ISO
Genome Projectcell-cell junction organization
GO:0045726
ISO
Genome Projectpositive regulation of integrin biosynthetic process
GO:0045823
ISO
Genome Projectpositive regulation of heart contraction
GO:0048663
IDA
Genome Projectneuron fate commitment
GO:0050680
ISO
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050714
ISO
Genome Projectpositive regulation of protein secretion
GO:0051795
ISO
Genome Projectpositive regulation of catagen
GO:0051891
ISO
Genome Projectpositive regulation of cardioblast differentiation
GO:0060038
ISO
Genome Projectcardiac muscle cell proliferation
GO:0060317
ISO
Genome Projectcardiac epithelial to mesenchymal transition
GO:0060389
ISO
Genome Projectpathway-restricted SMAD protein phosphorylation
GO:0060395
IBA
Genome ProjectSMAD protein signal transduction
GO:0061037
IMP
Genome Projectnegative regulation of cartilage development
GO:0070237
IDA
Genome Projectpositive regulation of activation-induced cell death of T cells
GO:0097191
ISO
Genome Projectextrinsic apoptotic signaling pathway
GO:1903053
IMP
Genome Projectregulation of extracellular matrix organization
GO:2001241
IDA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001540
ISO
Genome Projectbeta-amyloid binding
GO:0004702
ISO
Genome Projectreceptor signaling protein serine/threonine kinase activity
GO:0005102
ISO
Genome Projectreceptor binding
GO:0005114
ISO, IBA
Genome Projecttype II transforming growth factor beta receptor binding
GO:0005125
IBA
Genome Projectcytokine activity
GO:0005160
ISO
IEA
Genome Projecttransforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0034714
ISO
Genome Projecttype III transforming growth factor beta receptor binding
GO:0042803
ISO
Genome Projectprotein homodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
ISO
IEA
Genome Projectextracellular region
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0005622
ISO
Genome Projectintracellular
GO:0031012
ISO
Genome Projectextracellular matrix

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001111Transforming growth factor-beta, N-terminal
IPR001839Transforming growth factor-beta, C-terminal
IPR003940Transforming growth factor, beta 2
IPR015615Transforming growth factor-beta-related
IPR016319Transforming growth factor-beta
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.