Gene: ENSMUSG00000039005 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000039005
Transcript Identifier
ENSMUST00000048096
Gene Type
Coding gene
Location
4 : 66827832-66841479 : positive

Family Information

Homologous gene family
HOM03P004593
(20 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P066209
(2 genes in 2 species)
specific family

Descriptions

gene_descr
toll-like receptor 4

Identifiers

Type Value
UniprotQ9QUK6
UniprotL0CL36
MGI96824

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002218
IMP
Genome Projectactivation of innate immune response
GO:0002322
IMP
Genome ProjectB cell proliferation involved in immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002537
IMP
Genome Projectnitric oxide production involved in inflammatory response
GO:0002730
IDA
Genome Projectregulation of dendritic cell cytokine production
GO:0002755
IEA
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007252
IMP
ISO
IEA
Genome ProjectI-kappaB phosphorylation
GO:0009617
IMP
Genome Projectresponse to bacterium
GO:0010628
ISO
Genome Projectpositive regulation of gene expression
GO:0030890
IMP
Genome Projectpositive regulation of B cell proliferation
GO:0031663
IDA, IGI
ISO
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032496
IMP, IGI
ISO
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032497
ISO
TAS, IEA
Genome Projectdetection of lipopolysaccharide
GO:0032609
IGI
Genome Projectinterferon-gamma production
GO:0032722
IDA
ISO
IEA
Genome Projectpositive regulation of chemokine production
GO:0032733
IDA
Genome Projectpositive regulation of interleukin-10 production
GO:0032755
IDA, IMP
ISO
NAS, IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
ISO
IEA
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
IDA, IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032874
IDA
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0034142
IEA
Genome Projecttoll-like receptor 4 signaling pathway
GO:0042116
ISS, ISO
IEA
Genome Projectmacrophage activation
GO:0042346
ISO
IEA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042535
ISO
IEA
Genome Projectpositive regulation of tumor necrosis factor biosynthetic process
GO:0043123
IDA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084
ISO
IEA
Genome Projectpositive regulation of interleukin-12 biosynthetic process
GO:0045087
TAS, IEA
Genome Projectinnate immune response
GO:0045348
IMP
Genome Projectpositive regulation of MHC class II biosynthetic process
GO:0045359
IMP
Genome Projectpositive regulation of interferon-beta biosynthetic process
GO:0045416
ISO
IEA
Genome Projectpositive regulation of interleukin-8 biosynthetic process
GO:0045429
IMP
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0046330
IDA, IGI
Genome Projectpositive regulation of JNK cascade
GO:0050671
IMP
Genome Projectpositive regulation of lymphocyte proliferation
GO:0050707
IEA
Genome Projectregulation of cytokine secretion
GO:0050829
IMP
IEA
Genome Projectdefense response to Gram-negative bacterium
GO:0051092
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0060907
IMP
Genome Projectpositive regulation of macrophage cytokine production
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070430
IDA
Genome Projectpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434
IDA
Genome Projectpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222
IDA, IMP
Genome Projectcellular response to lipopolysaccharide
GO:0071223
IMP
Genome Projectcellular response to lipoteichoic acid
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0000187
IMP
Genome Projectactivation of MAPK activity
GO:0006954
IEA
Genome Projectinflammatory response
GO:0007250
NAS
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0010572
IMP
Genome Projectpositive regulation of platelet activation
GO:0032689
IMP
Genome Projectnegative regulation of interferon-gamma production
GO:0032700
IMP
Genome Projectnegative regulation of interleukin-17 production
GO:0032707
IMP
Genome Projectnegative regulation of interleukin-23 production
GO:0032715
IMP
Genome Projectnegative regulation of interleukin-6 production
GO:0032720
IMP
Genome Projectnegative regulation of tumor necrosis factor production
GO:0032727
IDA
Genome Projectpositive regulation of interferon-alpha production
GO:0032728
IDA
Genome Projectpositive regulation of interferon-beta production
GO:0032729
IMP
Genome Projectpositive regulation of interferon-gamma production
GO:0032732
IDA
Genome Projectpositive regulation of interleukin-1 production
GO:0032735
IDA
Genome Projectpositive regulation of interleukin-12 production
GO:0045362
NAS
Genome Projectpositive regulation of interleukin-1 biosynthetic process
GO:0045368
NAS
Genome Projectpositive regulation of interleukin-13 biosynthetic process
GO:0045410
NAS
Genome Projectpositive regulation of interleukin-6 biosynthetic process
GO:0045576
NAS
Genome Projectmast cell activation
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050727
IMP
Genome Projectregulation of inflammatory response
GO:0051770
IDA
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0060729
IMP
Genome Projectintestinal epithelial structure maintenance
GO:0070373
IMP
Genome Projectnegative regulation of ERK1 and ERK2 cascade

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001530
ISO
Genome Projectlipopolysaccharide binding
GO:0001875
ISS, ISO
Genome Projectlipopolysaccharide receptor activity
GO:0004888
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0005515
IPI
Genome Projectprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0005887
ISO
IEA
Genome Projectintegral component of plasma membrane
GO:0009897
ISO
IEA
Genome Projectexternal side of plasma membrane
GO:0009986
ISO
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0046696
ISS, ISO
IEA
Genome Projectlipopolysaccharide receptor complex
GO:0048471
ISO
IEA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000157Toll/interleukin-1 receptor homology (TIR) domain
IPR000483Cysteine-rich flanking region, C-terminal
IPR001611Leucine-rich repeat
IPR027168Toll-like receptor 4

No MapMan annotations defined for this gene.