Gene: ENSMUSG00000037171 (Mus musculus)

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Gene Identifier
ENSMUSG00000037171
Transcript Identifier
ENSMUST00000049339
Gene Type
Coding gene
Location
10 : 61418300-61424636 : positive

Family Information

Homologous gene family
HOM03P001000
(62 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P071498
(2 genes in 2 species)
specific family

Descriptions

gene_descr
nodal

Identifiers

Type Value
UniprotP43021
MGI97359

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0001702
IMP
Genome Projectgastrulation with mouth forming second
GO:0001707
IMP
TAS
Genome Projectmesoderm formation
GO:0001829
IDA
Genome Projecttrophectodermal cell differentiation
GO:0001831
IMP
Genome Projecttrophectodermal cellular morphogenesis
GO:0001842
IMP
Genome Projectneural fold formation
GO:0001889
IMP
Genome Projectliver development
GO:0001890
ISO
IEA
Genome Projectplacenta development
GO:0001892
IMP
Genome Projectembryonic placenta development
GO:0001893
IMP
Genome Projectmaternal placenta development
GO:0001944
IMP
Genome Projectvasculature development
GO:0001947
IGI
Genome Projectheart looping
GO:0002085
IMP
Genome Projectinhibition of neuroepithelial cell differentiation
GO:0007179
ISA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007368
IDA, IMP, IGI
TAS
Genome Projectdetermination of left/right symmetry
GO:0007369
IMP
Genome Projectgastrulation
GO:0007399
IMP
Genome Projectnervous system development
GO:0007420
IMP
Genome Projectbrain development
GO:0007492
IMP
Genome Projectendoderm development
GO:0007507
IMP
Genome Projectheart development
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0009880
IMP
Genome Projectembryonic pattern specification
GO:0009948
IMP
Genome Projectanterior/posterior axis specification
GO:0009952
IMP, IGI
Genome Projectanterior/posterior pattern specification
GO:0009966
IDA
Genome Projectregulation of signal transduction
GO:0010085
IMP
Genome Projectpolarity specification of proximal/distal axis
GO:0010470
IGI
Genome Projectregulation of gastrulation
GO:0010575
ISO
IEA
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010721
IMP
Genome Projectnegative regulation of cell development
GO:0010862
ISO, IBA
IEA
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016477
IMP
Genome Projectcell migration
GO:0019827
IMP, IGI
Genome Projectstem cell population maintenance
GO:0022409
ISO
IEA
Genome Projectpositive regulation of cell-cell adhesion
GO:0030324
IMP
Genome Projectlung development
GO:0032927
ISO
IEA
Genome Projectpositive regulation of activin receptor signaling pathway
GO:0033505
IMP
Genome Projectfloor plate morphogenesis
GO:0035050
IMP
Genome Projectembryonic heart tube development
GO:0035987
ISO
IEA
Genome Projectendodermal cell differentiation
GO:0038092
IMP
Genome Projectnodal signaling pathway
GO:0042074
IDA
Genome Projectcell migration involved in gastrulation
GO:0042981
IBA
Genome Projectregulation of apoptotic process
GO:0043280
ISO
IEA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043408
IBA
Genome Projectregulation of MAPK cascade
GO:0045165
IMP
Genome Projectcell fate commitment
GO:0045596
IDA
Genome Projectnegative regulation of cell differentiation
GO:0045766
IMP
ISO
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045944
IDA, IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048327
IMP
Genome Projectaxial mesodermal cell fate specification
GO:0048382
IMP
ISO
IEA
Genome Projectmesendoderm development
GO:0048468
IBA
Genome Projectcell development
GO:0048546
IMP
Genome Projectdigestive tract morphogenesis
GO:0048646
IMP
Genome Projectanatomical structure formation involved in morphogenesis
GO:0048701
IMP
Genome Projectembryonic cranial skeleton morphogenesis
GO:0048729
IMP
Genome Projecttissue morphogenesis
GO:0048859
IMP
Genome Projectformation of anatomical boundary
GO:0050679
ISO
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0051091
ISO
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0055123
IMP
Genome Projectdigestive system development
GO:0060136
IMP
Genome Projectembryonic process involved in female pregnancy
GO:0060137
IMP
Genome Projectmaternal process involved in parturition
GO:0060391
ISO
IEA
Genome Projectpositive regulation of SMAD protein import into nucleus
GO:0060395
IDA
Genome ProjectSMAD protein signal transduction
GO:0060460
IMP
Genome Projectleft lung morphogenesis
GO:0060766
ISO
IEA
Genome Projectnegative regulation of androgen receptor signaling pathway
GO:0060802
IMP
Genome Projectepiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
GO:0070374
ISO
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0090009
IGI
Genome Projectprimitive streak formation
GO:0090010
IMP
Genome Projecttransforming growth factor beta receptor signaling pathway involved in primitive streak formation
GO:1900164
IMP
Genome Projectnodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1901164
ISO
IEA
Genome Projectnegative regulation of trophoblast cell migration
GO:1901383
ISO
IEA
Genome Projectnegative regulation of chorionic trophoblast cell proliferation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
IBA
IEA
Genome Projectcytokine activity
GO:0005160
IBA
Genome Projecttransforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0048018
IDA
Genome Projectreceptor agonist activity
GO:0070698
ISO, IBA
IEA
Genome Projecttype I activin receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
TAS, IEA
Genome Projectextracellular region
GO:0005615
ISO
TAS, IEA
Genome Projectextracellular space

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001839Transforming growth factor-beta, C-terminal
IPR015615Transforming growth factor-beta-related
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.