Gene: ENSMUSG00000035799 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000035799
Transcript Identifier
ENSMUST00000049089
Gene Type
Coding gene
Location
12 : 33957978-33958598 : positive

Family Information

Homologous gene family
HOM03P005493
(16 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P066231
(2 genes in 2 species)
specific family

Descriptions

gene_descr
twist basic helix-loop-helix transcription factor 1

Identifiers

Type Value
UniprotP26687
MGI98872

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA
ISO
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001503
IMP
Genome Projectossification
GO:0001649
IMP
Genome Projectosteoblast differentiation
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0001764
IMP
Genome Projectneuron migration
GO:0001843
IMP
Genome Projectneural tube closure
GO:0003180
IMP
ISO
IEA
Genome Projectaortic valve morphogenesis
GO:0003183
IMP
Genome Projectmitral valve morphogenesis
GO:0003203
IMP
Genome Projectendocardial cushion morphogenesis
GO:0003253
IMP
Genome Projectcardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007517
IEA
Genome Projectmuscle organ development
GO:0010628
ISO
IEA
Genome Projectpositive regulation of gene expression
GO:0010718
IMP
ISO
IEA
Genome Projectpositive regulation of epithelial to mesenchymal transition
GO:0014067
ISO
IEA
Genome Projectnegative regulation of phosphatidylinositol 3-kinase signaling
GO:0030154
IMP
IEA
Genome Projectcell differentiation
GO:0030326
IMP
Genome Projectembryonic limb morphogenesis
GO:0030500
ISO
IEA
Genome Projectregulation of bone mineralization
GO:0032000
ISO
IEA
Genome Projectpositive regulation of fatty acid beta-oxidation
GO:0032720
IGI
Genome Projectnegative regulation of tumor necrosis factor production
GO:0032760
ISO
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0033128
ISO
IEA
Genome Projectnegative regulation of histone phosphorylation
GO:0035067
IDA
Genome Projectnegative regulation of histone acetylation
GO:0035115
IMP
Genome Projectembryonic forelimb morphogenesis
GO:0035116
IMP
Genome Projectembryonic hindlimb morphogenesis
GO:0035137
IMP
Genome Projecthindlimb morphogenesis
GO:0035359
IDA
Genome Projectnegative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042476
IEA
Genome Projectodontogenesis
GO:0042733
IMP
Genome Projectembryonic digit morphogenesis
GO:0043066
IMP
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043433
IDA
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518
ISO
IEA
Genome Projectnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044092
IDA
Genome Projectnegative regulation of molecular function
GO:0045596
IDA
Genome Projectnegative regulation of cell differentiation
GO:0045668
IDA
ISO
IEA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045843
IDA
Genome Projectnegative regulation of striated muscle tissue development
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045944
IDA
ISO
TAS, IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048511
IEA
Genome Projectrhythmic process
GO:0048642
IDA
Genome Projectnegative regulation of skeletal muscle tissue development
GO:0048701
IMP, IGI
ISO
IEA
Genome Projectembryonic cranial skeleton morphogenesis
GO:0048704
IMP
Genome Projectembryonic skeletal system morphogenesis
GO:0050679
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0060021
IEA
Genome Projectpalate development
GO:0060348
IEA
Genome Projectbone development
GO:0060363
IMP
Genome Projectcranial suture morphogenesis
GO:0060900
ISO
IEA
Genome Projectembryonic camera-type eye formation
GO:0061029
ISO
IEA
Genome Projecteyelid development in camera-type eye
GO:0061309
IMP
Genome Projectcardiac neural crest cell development involved in outflow tract morphogenesis
GO:0071363
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071456
IMP
ISO
IEA
Genome Projectcellular response to hypoxia
GO:0071639
ISO
IEA
Genome Projectpositive regulation of monocyte chemotactic protein-1 production
GO:2000144
ISO
IEA
Genome Projectpositive regulation of DNA-templated transcription, initiation
GO:2000147
IMP
ISO
Genome Projectpositive regulation of cell motility
GO:2000276
IDA
Genome Projectnegative regulation of oxidative phosphorylation uncoupler activity
GO:2000679
ISO
IEA
Genome Projectpositive regulation of transcription regulatory region DNA binding
GO:2000773
ISO
IEA
Genome Projectnegative regulation of cellular senescence
GO:2000778
ISO
IEA
Genome Projectpositive regulation of interleukin-6 secretion
GO:2000780
ISO
IEA
Genome Projectnegative regulation of double-strand break repair
GO:2000793
IMP
ISO
IEA
Genome Projectcell proliferation involved in heart valve development
GO:2000802
IDA
Genome Projectpositive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000981
ISO
IEA
Genome ProjectRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077
TAS
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003700
IDA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
ISO
IEA
Genome Projecttranscription factor binding
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0043425
ISO
IEA
Genome ProjectbHLH transcription factor binding
GO:0046982
IDA
Genome Projectprotein heterodimerization activity
GO:0046983
IEA
Genome Projectprotein dimerization activity
GO:0070888
IDA
ISO
TAS, IEA
Genome ProjectE-box binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
IPR015789Twist-related

No MapMan annotations defined for this gene.