Gene: ENSMUSG00000032691 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000032691
Transcript Identifier
ENSMUST00000101148
Gene Type
Coding gene
Location
11 : 59543113-59566263 : positive

Family Information

Homologous gene family
HOM03P001064
(59 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P000963
(41 genes in 2 species)
specific family

Descriptions

gene_descr
NLR family, pyrin domain containing 3

Identifiers

Type Value
UniprotQ8R4B8
MGI2653833

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002376
IEA
Genome Projectimmune system process
GO:0002674
ISO
IEA
Genome Projectnegative regulation of acute inflammatory response
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006919
IMP
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954
ISS, ISO
IEA
Genome Projectinflammatory response
GO:0032088
ISS, ISO
IEA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032611
IMP
Genome Projectinterleukin-1 beta production
GO:0032621
IMP
Genome Projectinterleukin-18 production
GO:0042347
ISS, ISO
IEA
Genome Projectnegative regulation of NF-kappaB import into nucleus
GO:0043280
ISS, ISO
IEA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044546
IMP
Genome ProjectNLRP3 inflammasome complex assembly
GO:0045087
IEA
Genome Projectinnate immune response
GO:0050701
IMP
Genome Projectinterleukin-1 secretion
GO:0050713
ISO
IEA
Genome Projectnegative regulation of interleukin-1 beta secretion
GO:0050718
IGI
ISS, ISO
IEA
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050727
IMP
Genome Projectregulation of inflammatory response
GO:0050728
ISO
IEA
Genome Projectnegative regulation of inflammatory response
GO:0051092
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051607
IMP
Genome Projectdefense response to virus
GO:0071222
ISO
IEA
Genome Projectcellular response to lipopolysaccharide

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0072559
ISS, ISO
IEA
Genome ProjectNLRP3 inflammasome complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001611Leucine-rich repeat
IPR003590Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020DAPIN domain
IPR007111NACHT nucleoside triphosphatase
IPR011029Death-like domain
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR029495NACHT-associated domain

No MapMan annotations defined for this gene.