Gene: ENSMUSG00000032440 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000032440
Transcript Identifier
ENSMUST00000061101
Gene Type
Coding gene
Location
9 : 116090378-116175037 : negative

Family Information

Homologous gene family
HOM03P000002
(4173 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P066625
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
transforming growth factor, beta receptor II

Identifiers

Type Value
UniprotQ62312
UniprotQ543C0
MGI98729

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001569
IMP
Genome Projectpatterning of blood vessels
GO:0001570
IMP
IEA
Genome Projectvasculogenesis
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0002088
IMP
Genome Projectlens development in camera-type eye
GO:0002651
IMP
Genome Projectpositive regulation of tolerance induction to self antigen
GO:0002663
IMP
Genome Projectpositive regulation of B cell tolerance induction
GO:0002666
IMP
Genome Projectpositive regulation of T cell tolerance induction
GO:0003417
IGI
Genome Projectgrowth plate cartilage development
GO:0003430
IMP
Genome Projectgrowth plate cartilage chondrocyte growth
GO:0006468
ISO
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006898
IEA
Genome Projectreceptor-mediated endocytosis
GO:0006915
ISO
IEA
Genome Projectapoptotic process
GO:0007178
IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179
IMP
ISO
IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007182
IEA
Genome Projectcommon-partner SMAD protein phosphorylation
GO:0007219
IDA
Genome ProjectNotch signaling pathway
GO:0007224
IMP
Genome Projectsmoothened signaling pathway
GO:0007369
IMP
Genome Projectgastrulation
GO:0007507
IMP
Genome Projectheart development
GO:0007566
IEA
Genome Projectembryo implantation
GO:0007568
IEA
Genome Projectaging
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009749
IEA
Genome Projectresponse to glucose
GO:0009887
IEA
Genome Projectorgan morphogenesis
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010468
IMP
Genome Projectregulation of gene expression
GO:0010634
IMP
Genome Projectpositive regulation of epithelial cell migration
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
ISO
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
ISO
IEA
Genome Projectpeptidyl-threonine phosphorylation
GO:0023014
IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030324
IMP
IEA
Genome Projectlung development
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0032147
IDA
Genome Projectactivation of protein kinase activity
GO:0040008
IEA
Genome Projectregulation of growth
GO:0042060
IEA
Genome Projectwound healing
GO:0042127
IMP
Genome Projectregulation of cell proliferation
GO:0042493
ISO
IEA
Genome Projectresponse to drug
GO:0043011
IMP
Genome Projectmyeloid dendritic cell differentiation
GO:0043415
IEA
Genome Projectpositive regulation of skeletal muscle tissue regeneration
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045766
IGI
Genome Projectpositive regulation of angiogenesis
GO:0048545
IEA
Genome Projectresponse to steroid hormone
GO:0048565
IEA
Genome Projectdigestive tract development
GO:0048661
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0051138
IMP
Genome Projectpositive regulation of NK T cell differentiation
GO:0060044
IEA
Genome Projectnegative regulation of cardiac muscle cell proliferation
GO:0060389
ISO
IEA
Genome Projectpathway-restricted SMAD protein phosphorylation
GO:0060425
IMP
Genome Projectlung morphogenesis
GO:0060433
IMP
Genome Projectbronchus development
GO:0060434
IMP
Genome Projectbronchus morphogenesis
GO:0060439
IMP
Genome Projecttrachea morphogenesis
GO:0060440
IMP
Genome Projecttrachea formation
GO:0060443
IMP
Genome Projectmammary gland morphogenesis
GO:0060463
IMP
Genome Projectlung lobe morphogenesis
GO:0070723
IDA
ISO
IEA
Genome Projectresponse to cholesterol
GO:1990086
IDA
Genome Projectlens fiber cell apoptotic process
GO:2000379
ISO
IEA
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:0002053
IMP
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0007420
IMP
Genome Projectbrain development
GO:0035162
IMP
Genome Projectembryonic hemopoiesis
GO:0048701
IMP
Genome Projectembryonic cranial skeleton morphogenesis
GO:0051216
IMP
Genome Projectcartilage development
GO:0060021
IMP
Genome Projectpalate development

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004675
ISO
IEA
Genome Projecttransmembrane receptor protein serine/threonine kinase activity
GO:0004702
IEA
Genome Projectreceptor signaling protein serine/threonine kinase activity
GO:0004872
IEA
Genome Projectreceptor activity
GO:0005024
IGI
ISO
Genome Projecttransforming growth factor beta-activated receptor activity
GO:0005026
IEA
Genome Projecttransforming growth factor beta receptor activity, type II
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0005539
ISO
IEA
Genome Projectglycosaminoglycan binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031435
IEA
Genome Projectmitogen-activated protein kinase kinase kinase binding
GO:0034713
ISO
IEA
Genome Projecttype I transforming growth factor beta receptor binding
GO:0034714
ISO
IEA
Genome Projecttype III transforming growth factor beta receptor binding
GO:0046332
IDA
ISO
IEA
Genome ProjectSMAD binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0050431
IPI
ISO
IEA
Genome Projecttransforming growth factor beta binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
IEA
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005887
IEA
Genome Projectintegral component of plasma membrane
GO:0005901
ISO
IEA
Genome Projectcaveola
GO:0009897
IDA
ISO
IEA
Genome Projectexternal side of plasma membrane
GO:0009986
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
ISO
IEA
Genome Projectintegral component of membrane
GO:0043235
ISO
IEA
Genome Projectreceptor complex
GO:0045121
ISO
IEA
Genome Projectmembrane raft

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000333Ser/Thr protein kinase, TGFB receptor
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR015013Transforming growth factor beta receptor 2 ectodomain
IPR017194Transforming growth factor-beta receptor, type II
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.