Gene: ENSMUSG00000032259 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000032259
Transcript Identifier
ENSMUST00000075764
Gene Type
Coding gene
Location
9 : 49395616-49407094 : positive

Family Information

Homologous gene family
HOM03P000241
(150 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P042956
(3 genes in 3 species)
specific family

Descriptions

gene_descr
dopamine receptor D2

Identifiers

Type Value
UniprotP61168
MGI94924

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001659
IMP
Genome Projecttemperature homeostasis
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001963
IBA
IEA
Genome Projectsynaptic transmission, dopaminergic
GO:0001964
IMP
Genome Projectstartle response
GO:0001975
IMP, IGI
IEA
Genome Projectresponse to amphetamine
GO:0001976
IMP
Genome Projectneurological system process involved in regulation of systemic arterial blood pressure
GO:0002027
IMP
Genome Projectregulation of heart rate
GO:0002028
IMP
Genome Projectregulation of sodium ion transport
GO:0002031
IEA
Genome ProjectG-protein coupled receptor internalization
GO:0002052
IDA
Genome Projectpositive regulation of neuroblast proliferation
GO:0002092
IEA
Genome Projectpositive regulation of receptor internalization
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
IDA
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007188
IEA
Genome Projectadenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194
ISO, IBA
IEA
Genome Projectnegative regulation of adenylate cyclase activity
GO:0007195
IDA, IMP, IGI
ISO
IEA
Genome Projectadenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212
IGI
IEA
Genome Projectdopamine receptor signaling pathway
GO:0007270
IMP
Genome Projectneuron-neuron synaptic transmission
GO:0007409
IMP
Genome Projectaxonogenesis
GO:0007416
IEA
Genome Projectsynapse assembly
GO:0007608
IMP
Genome Projectsensory perception of smell
GO:0007616
IEA
Genome Projectlong-term memory
GO:0007625
IMP
Genome Projectgrooming behavior
GO:0007626
IMP, IGI
IEA
Genome Projectlocomotory behavior
GO:0007628
IMP
Genome Projectadult walking behavior
GO:0007631
IGI
Genome Projectfeeding behavior
GO:0008104
IMP
Genome Projectprotein localization
GO:0008285
IMP, IGI
Genome Projectnegative regulation of cell proliferation
GO:0008306
IMP
Genome Projectassociative learning
GO:0008542
IMP
Genome Projectvisual learning
GO:0009416
IMP
Genome Projectresponse to light stimulus
GO:0009636
IBA
IEA
Genome Projectresponse to toxic substance
GO:0010039
IEA
Genome Projectresponse to iron ion
GO:0014059
IMP
Genome Projectregulation of dopamine secretion
GO:0014854
IEA
Genome Projectresponse to inactivity
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0021756
IEA
Genome Projectstriatum development
GO:0021769
IEA
Genome Projectorbitofrontal cortex development
GO:0021853
IMP
Genome Projectcerebral cortex GABAergic interneuron migration
GO:0021984
IMP
Genome Projectadenohypophysis development
GO:0030336
IMP
Genome Projectnegative regulation of cell migration
GO:0030432
IMP, IGI
Genome Projectperistalsis
GO:0030534
IMP
Genome Projectadult behavior
GO:0030814
ISO
IEA
Genome Projectregulation of cAMP metabolic process
GO:0030900
IEA
Genome Projectforebrain development
GO:0031223
IEA
Genome Projectauditory behavior
GO:0032147
IEA
Genome Projectactivation of protein kinase activity
GO:0032228
IMP, IGI
Genome Projectregulation of synaptic transmission, GABAergic
GO:0032467
ISO
IEA
Genome Projectpositive regulation of cytokinesis
GO:0032922
IMP
Genome Projectcircadian regulation of gene expression
GO:0033602
IEA
Genome Projectnegative regulation of dopamine secretion
GO:0034776
ISO
IEA
Genome Projectresponse to histamine
GO:0035094
IEA
Genome Projectresponse to nicotine
GO:0035556
ISO
IEA
Genome Projectintracellular signal transduction
GO:0035810
IMP
Genome Projectpositive regulation of urine volume
GO:0035815
IMP
Genome Projectpositive regulation of renal sodium excretion
GO:0040018
IMP
Genome Projectpositive regulation of multicellular organism growth
GO:0042220
IDA, IMP
Genome Projectresponse to cocaine
GO:0042321
IEA
Genome Projectnegative regulation of circadian sleep/wake cycle, sleep
GO:0042417
IMP
Genome Projectdopamine metabolic process
GO:0042493
IDA, IMP
IEA
Genome Projectresponse to drug
GO:0043266
IMP
IEA
Genome Projectregulation of potassium ion transport
GO:0043278
IMP
Genome Projectresponse to morphine
GO:0043408
IEA
Genome Projectregulation of MAPK cascade
GO:0043473
IMP
Genome Projectpigmentation
GO:0043666
IEA
Genome Projectregulation of phosphoprotein phosphatase activity
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0045745
IEA
Genome Projectpositive regulation of G-protein coupled receptor protein signaling pathway
GO:0045776
IMP
Genome Projectnegative regulation of blood pressure
GO:0045824
IMP
Genome Projectnegative regulation of innate immune response
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046488
IEA
Genome Projectphosphatidylinositol metabolic process
GO:0046676
IEA
Genome Projectnegative regulation of insulin secretion
GO:0046717
IEA
Genome Projectacid secretion
GO:0048148
IMP
Genome Projectbehavioral response to cocaine
GO:0048149
IMP
Genome Projectbehavioral response to ethanol
GO:0048169
IMP
Genome Projectregulation of long-term neuronal synaptic plasticity
GO:0048678
IEA
Genome Projectresponse to axon injury
GO:0048755
IMP
Genome Projectbranching morphogenesis of a nerve
GO:0050482
ISO
IEA
Genome Projectarachidonic acid secretion
GO:0050709
ISO
IEA
Genome Projectnegative regulation of protein secretion
GO:0050804
IMP
IEA
Genome Projectmodulation of synaptic transmission
GO:0051209
IEA
Genome Projectrelease of sequestered calcium ion into cytosol
GO:0051481
IBA
IEA
Genome Projectnegative regulation of cytosolic calcium ion concentration
GO:0051482
ISO, IBA
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584
IMP
Genome Projectregulation of dopamine uptake involved in synaptic transmission
GO:0051586
IMP
Genome Projectpositive regulation of dopamine uptake involved in synaptic transmission
GO:0051823
IEA
Genome Projectregulation of synapse structural plasticity
GO:0051898
IMP
Genome Projectnegative regulation of protein kinase B signaling
GO:0051967
IMP
Genome Projectnegative regulation of synaptic transmission, glutamatergic
GO:0060124
IMP
Genome Projectpositive regulation of growth hormone secretion
GO:0060134
IMP
Genome Projectprepulse inhibition
GO:0060158
IDA, IGI
ISO
IEA
Genome Projectphospholipase C-activating dopamine receptor signaling pathway
GO:0060160
IMP, IGI
Genome Projectnegative regulation of dopamine receptor signaling pathway
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0090325
IEA
Genome Projectregulation of locomotion involved in locomotory behavior
GO:1900168
ISO
IEA
Genome Projectpositive regulation of glial cell-derived neurotrophic factor secretion
GO:1900273
IEA
Genome Projectpositive regulation of long-term synaptic potentiation
GO:1901386
ISO, IBA
IEA
Genome Projectnegative regulation of voltage-gated calcium channel activity
GO:0071880
IBA
Genome Projectadenylate cyclase-activating adrenergic receptor signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001591
IDA, IMP
ISO
IEA
Genome Projectdopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004871
IEA
Genome Projectsignal transducer activity
GO:0004930
IDA
IEA
Genome ProjectG-protein coupled receptor activity
GO:0004952
IDA
IEA
Genome Projectdopamine neurotransmitter receptor activity
GO:0005102
IEA
Genome Projectreceptor binding
GO:0008144
ISO
IEA
Genome Projectdrug binding
GO:0035240
IDA
IEA
Genome Projectdopamine binding
GO:0035255
IEA
Genome Projectionotropic glutamate receptor binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0004935
IBA
Genome Projectadrenergic receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001669
IEA
Genome Projectacrosomal vesicle
GO:0005622
ISO
Genome Projectintracellular
GO:0005829
ISO
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005887
ISO, IBA
IEA
Genome Projectintegral component of plasma membrane
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016328
IEA
Genome Projectlateral plasma membrane
GO:0030139
IEA
Genome Projectendocytic vesicle
GO:0030424
IDA
IEA
Genome Projectaxon
GO:0030425
IDA
IEA
Genome Projectdendrite
GO:0030672
IBA
IEA
Genome Projectsynaptic vesicle membrane
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0031513
ISO
Genome Projectnonmotile primary cilium
GO:0036126
IEA
Genome Projectsperm flagellum
GO:0043197
IEA
Genome Projectdendritic spine
GO:0043204
IEA
Genome Projectperikaryon
GO:0043679
IEA
Genome Projectaxon terminus
GO:0060170
ISO
Genome Projectciliary membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000276G protein-coupled receptor, rhodopsin-like
IPR000929Dopamine receptor family
IPR001922Dopamine D2 receptor
IPR017452GPCR, rhodopsin-like, 7TM

No MapMan annotations defined for this gene.