Gene: ENSMUSG00000031668 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000031668
Transcript Identifier
ENSMUST00000034093
Gene Type
Coding gene
Location
6 : 70844726-70904288 : positive

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P039733
(3 genes in 3 species)
specific family

Descriptions

gene_descr
eukaryotic translation initiation factor 2 alpha kinase 3

Identifiers

Type Value
UniprotE9QQ30
MGI1341830

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001501
IMP
Genome Projectskeletal system development
GO:0001503
ISO
IEA
Genome Projectossification
GO:0001525
ISO
IEA
Genome Projectangiogenesis
GO:0002063
IMP
Genome Projectchondrocyte development
GO:0006412
IDA
Genome Projecttranslation
GO:0006468
IDA, IMP
IEA
Genome Projectprotein phosphorylation
GO:0006919
IMP
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983
ISO
IEA
Genome ProjectER overload response
GO:0007029
IMP
Genome Projectendoplasmic reticulum organization
GO:0007595
IMP
Genome Projectlactation
GO:0009967
IDA
Genome Projectpositive regulation of signal transduction
GO:0010575
ISO
IEA
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010628
ISO
IEA
Genome Projectpositive regulation of gene expression
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0010998
ISO
IEA
Genome Projectregulation of translational initiation by eIF2 alpha phosphorylation
GO:0017148
IDA, IMP, IGI
Genome Projectnegative regulation of translation
GO:0019217
IMP
Genome Projectregulation of fatty acid metabolic process
GO:0019722
IMP
Genome Projectcalcium-mediated signaling
GO:0030282
IMP
Genome Projectbone mineralization
GO:0030968
IDA, IMP
ISO
IEA
Genome Projectendoplasmic reticulum unfolded protein response
GO:0031016
IMP
Genome Projectpancreas development
GO:0031018
ISO
IEA
Genome Projectendocrine pancreas development
GO:0031642
IMP
Genome Projectnegative regulation of myelination
GO:0032055
IEA
Genome Projectnegative regulation of translation in response to stress
GO:0032092
IMP
Genome Projectpositive regulation of protein binding
GO:0032933
IDA
Genome ProjectSREBP signaling pathway
GO:0034976
ISO
IEA
Genome Projectresponse to endoplasmic reticulum stress
GO:0042149
ISO
IEA
Genome Projectcellular response to glucose starvation
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0045444
IDA
Genome Projectfat cell differentiation
GO:0045943
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase I promoter
GO:0046777
IDA, IMP
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048009
IMP
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0051260
ISO
IEA
Genome Projectprotein homooligomerization
GO:0070059
IMP
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1902235
ISO
IEA
Genome Projectregulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902237
IGI
Genome Projectpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004672
IDA, IMP
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004694
ISO
IEA
Genome Projecteukaryotic translation initiation factor 2alpha kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0019903
ISO
IEA
Genome Projectprotein phosphatase binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0051879
IEA
Genome ProjectHsp90 protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005623
IEA
Genome Projectcell
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005783
IDA
Genome Projectendoplasmic reticulum
GO:0005789
IDA
Genome Projectendoplasmic reticulum membrane
GO:0016020
ISO
IEA
Genome Projectmembrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011047Quinoprotein alcohol dehydrogenase-like superfamily
IPR027295Quinoprotein alcohol dehydrogenase-like domain

No MapMan annotations defined for this gene.