Gene: ENSMUSG00000031583 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000031583
Transcript Identifier
ENSMUST00000033990
Gene Type
Coding gene
Location
8 : 33236337-33353372 : negative

Family Information

Homologous gene family
HOM03P000141
(210 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P003380
(24 genes in 22 species)
specific family

Descriptions

gene_descr
Werner syndrome homolog (human)

Identifiers

Type Value
UniprotO09053
MGI109635

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000723
IMP, IGI
ISO
IEA
Genome Projecttelomere maintenance
GO:0000731
ISO
IEA
Genome ProjectDNA synthesis involved in DNA repair
GO:0001302
IMP
Genome Projectreplicative cell aging
GO:0006139
IEA
Genome Projectnucleobase-containing compound metabolic process
GO:0006259
IMP
ISS, ISO
IEA
Genome ProjectDNA metabolic process
GO:0006260
IMP
ISO
IEA
Genome ProjectDNA replication
GO:0006281
IEA
Genome ProjectDNA repair
GO:0006284
ISO
IEA
Genome Projectbase-excision repair
GO:0006302
ISS, ISO
IEA
Genome Projectdouble-strand break repair
GO:0006310
IEA
Genome ProjectDNA recombination
GO:0006974
ISO
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0006979
ISO
IEA
Genome Projectresponse to oxidative stress
GO:0007569
ISO
IEA
Genome Projectcell aging
GO:0008152
IEA
Genome Projectmetabolic process
GO:0009267
ISO
IEA
Genome Projectcellular response to starvation
GO:0010225
ISO
IEA
Genome Projectresponse to UV-C
GO:0010259
IGI
ISO
IEA
Genome Projectmulticellular organismal aging
GO:0031297
ISO
IEA
Genome Projectreplication fork processing
GO:0032066
ISO
IEA
Genome Projectnucleolus to nucleoplasm transport
GO:0032508
ISO
Genome ProjectDNA duplex unwinding
GO:0040009
IMP
Genome Projectregulation of growth rate
GO:0042981
ISO
IEA
Genome Projectregulation of apoptotic process
GO:0044237
IEA
Genome Projectcellular metabolic process
GO:0051345
ISO
IEA
Genome Projectpositive regulation of hydrolase activity
GO:0071480
ISS, ISO
IEA
Genome Projectcellular response to gamma radiation
GO:0090305
ISO
Genome Projectnucleic acid phosphodiester bond hydrolysis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0000287
ISS, ISO
IEA
Genome Projectmagnesium ion binding
GO:0000403
ISO
IEA
Genome ProjectY-form DNA binding
GO:0000405
ISO
IEA
Genome Projectbubble DNA binding
GO:0003676
IEA
Genome Projectnucleic acid binding
GO:0003677
ISO
IEA
Genome ProjectDNA binding
GO:0003678
ISO
IEA
Genome ProjectDNA helicase activity
GO:0003824
IEA
Genome Projectcatalytic activity
GO:0004003
ISO
IEA
Genome ProjectATP-dependent DNA helicase activity
GO:0004386
ISO
IEA
Genome Projecthelicase activity
GO:0004518
IEA
Genome Projectnuclease activity
GO:0004527
ISO
IEA
Genome Projectexonuclease activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008026
IEA
Genome ProjectATP-dependent helicase activity
GO:0008408
IDA
ISS, ISO
IEA
Genome Project3'-5' exonuclease activity
GO:0009378
ISO
IEA
Genome Projectfour-way junction helicase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0016887
ISO
IEA
Genome ProjectATPase activity
GO:0030145
ISS, ISO
IEA
Genome Projectmanganese ion binding
GO:0032403
ISO
IEA
Genome Projectprotein complex binding
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0043138
ISO
IEA
Genome Project3'-5' DNA helicase activity
GO:0043140
IEA
Genome ProjectATP-dependent 3'-5' DNA helicase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0051880
ISO
IEA
Genome ProjectG-quadruplex DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
ISO
IEA
Genome Projectnucleoplasm
GO:0005730
IDA
ISO
Genome Projectnucleolus
GO:0005813
ISO
IEA
Genome Projectcentrosome
GO:0032389
ISO
IEA
Genome ProjectMutLalpha complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001650Helicase, C-terminal
IPR002121HRDC domain
IPR0025623'-5' exonuclease domain
IPR004589DNA helicase, ATP-dependent, RecQ type
IPR010997HRDC-like
IPR011545DEAD/DEAH box helicase domain
IPR011991Winged helix-turn-helix DNA-binding domain
IPR012337Ribonuclease H-like domain
IPR014001Helicase superfamily 1/2, ATP-binding domain
IPR018982RQC domain
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR029491Helicase Helix-turn-helix domain
IPR032284ATP-dependent DNA helicase RecQ, zinc-binding domain

No MapMan annotations defined for this gene.