Gene: ENSMUSG00000031548 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000031548
Transcript Identifier
ENSMUST00000033952
Gene Type
Coding gene
Location
8 : 23411785-23446488 : positive

Family Information

Homologous gene family
HOM03P002165
(40 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P066970
(2 genes in 2 species)
specific family

Descriptions

gene_descr
secreted frizzled-related protein 1

Identifiers

Type Value
UniprotQ8C4U3
MGI892014

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001649
IEA
Genome Projectosteoblast differentiation
GO:0001657
IEP
Genome Projectureteric bud development
GO:0001756
IGI, IEP
Genome Projectsomitogenesis
GO:0001843
IGI
Genome Projectneural tube closure
GO:0002244
ISO
IEA
Genome Projecthematopoietic progenitor cell differentiation
GO:0006508
ISO
IEA
Genome Projectproteolysis
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008284
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008584
IGI
Genome Projectmale gonad development
GO:0008585
IGI
Genome Projectfemale gonad development
GO:0009267
IEA
Genome Projectcellular response to starvation
GO:0009950
ISO
IEA
Genome Projectdorsal/ventral axis specification
GO:0009952
IGI
Genome Projectanterior/posterior pattern specification
GO:0010564
ISO
IEA
Genome Projectregulation of cell cycle process
GO:0010629
IMP
ISO
IEA
Genome Projectnegative regulation of gene expression
GO:0010719
ISO
IEA
Genome Projectnegative regulation of epithelial to mesenchymal transition
GO:0014034
IMP
Genome Projectneural crest cell fate commitment
GO:0014070
ISO
IEA
Genome Projectresponse to organic cyclic compound
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0021915
IGI
Genome Projectneural tube development
GO:0030036
ISO
Genome Projectactin cytoskeleton organization
GO:0030097
IMP
Genome Projecthemopoiesis
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030177
ISO
IEA
Genome Projectpositive regulation of Wnt signaling pathway
GO:0030178
IGI
ISO
IEA
Genome Projectnegative regulation of Wnt signaling pathway
GO:0030278
IEA
Genome Projectregulation of ossification
GO:0030279
IMP
ISO
IEA
Genome Projectnegative regulation of ossification
GO:0030307
ISO
IEA
Genome Projectpositive regulation of cell growth
GO:0030308
ISO
IEA
Genome Projectnegative regulation of cell growth
GO:0030336
ISO
IEA
Genome Projectnegative regulation of cell migration
GO:0030514
IGI
Genome Projectnegative regulation of BMP signaling pathway
GO:0033689
IMP
ISO
IEA
Genome Projectnegative regulation of osteoblast proliferation
GO:0034446
ISO
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0035019
IMP
Genome Projectsomatic stem cell population maintenance
GO:0042493
IDA
ISO
IEA
Genome Projectresponse to drug
GO:0043065
ISO
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043508
IGI
Genome Projectnegative regulation of JUN kinase activity
GO:0044344
ISO
IEA
Genome Projectcellular response to fibroblast growth factor stimulus
GO:0044345
IEP
Genome Projectstromal-epithelial cell signaling involved in prostate gland development
GO:0045578
IMP
ISO
IEA
Genome Projectnegative regulation of B cell differentiation
GO:0045600
ISO
IEA
Genome Projectpositive regulation of fat cell differentiation
GO:0045668
IMP
Genome Projectnegative regulation of osteoblast differentiation
GO:0045671
IMP
IEA
Genome Projectnegative regulation of osteoclast differentiation
GO:0045880
ISO
IEA
Genome Projectpositive regulation of smoothened signaling pathway
GO:0045892
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0046546
IGI
Genome Projectdevelopment of primary male sexual characteristics
GO:0046676
ISO
IEA
Genome Projectnegative regulation of insulin secretion
GO:0046851
ISO
IEA
Genome Projectnegative regulation of bone remodeling
GO:0048147
ISO
IEA
Genome Projectnegative regulation of fibroblast proliferation
GO:0048546
IGI
Genome Projectdigestive tract morphogenesis
GO:0050679
ISO
IEA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050680
ISO
IEA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050732
ISO
IEA
Genome Projectnegative regulation of peptidyl-tyrosine phosphorylation
GO:0060070
ISO, IBA
IEA
Genome Projectcanonical Wnt signaling pathway
GO:0060071
IDA
Genome ProjectWnt signaling pathway, planar cell polarity pathway
GO:0060218
ISO
IEA
Genome Projecthematopoietic stem cell differentiation
GO:0060346
IMP
Genome Projectbone trabecula formation
GO:0060527
IMP
Genome Projectprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687
IMP
Genome Projectregulation of branching involved in prostate gland morphogenesis
GO:0060766
ISO
IEA
Genome Projectnegative regulation of androgen receptor signaling pathway
GO:0071305
IEA
Genome Projectcellular response to vitamin D
GO:0071347
IEA
Genome Projectcellular response to interleukin-1
GO:0071356
ISO
IEA
Genome Projectcellular response to tumor necrosis factor
GO:0071363
ISO
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071380
IEA
Genome Projectcellular response to prostaglandin E stimulus
GO:0071391
IDA
ISO
IEA
Genome Projectcellular response to estrogen stimulus
GO:0071392
IEA
Genome Projectcellular response to estradiol stimulus
GO:0071456
IEA
Genome Projectcellular response to hypoxia
GO:0071481
IDA
Genome Projectcellular response to X-ray
GO:0071504
ISO
IEA
Genome Projectcellular response to heparin
GO:0071560
IEA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0071773
IEA
Genome Projectcellular response to BMP stimulus
GO:0090090
IDA, IGI
ISO
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090175
IGI
Genome Projectregulation of establishment of planar polarity
GO:0090179
IGI
Genome Projectplanar cell polarity pathway involved in neural tube closure
GO:0090244
IGI
Genome ProjectWnt signaling pathway involved in somitogenesis
GO:0090246
IGI
Genome Projectconvergent extension involved in somitogenesis
GO:0090263
ISO
IEA
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1902043
ISO
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000041
IGI
Genome Projectnegative regulation of planar cell polarity pathway involved in axis elongation
GO:2000052
ISO
IEA
Genome Projectpositive regulation of non-canonical Wnt signaling pathway
GO:2000054
ISO
IEA
Genome Projectnegative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:2000080
ISO
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
GO:2000270
ISO
IEA
Genome Projectnegative regulation of fibroblast apoptotic process
GO:2000271
ISO
IEA
Genome Projectpositive regulation of fibroblast apoptotic process
GO:2001238
IMP
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004197
ISO
IEA
Genome Projectcysteine-type endopeptidase activity
GO:0005109
ISO
IEA
Genome Projectfrizzled binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008144
ISO
IEA
Genome Projectdrug binding
GO:0008201
ISO
IEA
Genome Projectheparin binding
GO:0017147
IPI
ISO
IEA
Genome ProjectWnt-protein binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0004930
IBA
Genome ProjectG-protein coupled receptor activity
GO:0042813
IBA
Genome ProjectWnt-activated receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005578
ISO
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005615
ISO, IBA
IEA
Genome Projectextracellular space
GO:0005622
ISO
IEA
Genome Projectintracellular
GO:0005829
ISO
IEA
Genome Projectcytosol
GO:0005886
ISO
Genome Projectplasma membrane
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0031012
ISO
IEA
Genome Projectextracellular matrix
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0016021
IBA
Genome Projectintegral component of membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001134Netrin domain
IPR008993Tissue inhibitor of metalloproteinases-like, OB-fold
IPR015526Frizzled/secreted frizzled-related protein
IPR018933Netrin module, non-TIMP type
IPR020067Frizzled domain
IPR026559Secreted frizzled-related protein 1

No MapMan annotations defined for this gene.