Gene: ENSMUSG00000031392 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000031392
Transcript Identifier
ENSMUST00000033769
Gene Type
Coding gene
Location
X : 74015440-74023745 : negative

Family Information

Homologous gene family
HOM03P000002
(4173 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P067363
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
interleukin-1 receptor-associated kinase 1

Identifiers

Type Value
UniprotB1AUW6
MGI107420

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001959
ISO
IEA
Genome Projectregulation of cytokine-mediated signaling pathway
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007250
ISO
IEA
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0007254
IEA
Genome ProjectJNK cascade
GO:0007568
IEA
Genome Projectaging
GO:0019221
IDA
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0031663
IDA
ISO
IEA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032088
ISO
IEA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032494
IDA
Genome Projectresponse to peptidoglycan
GO:0032496
IDA
ISO
IEA
Genome Projectresponse to lipopolysaccharide
GO:0034134
IDA
ISO
IEA
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034142
IDA
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034605
IEA
Genome Projectcellular response to heat
GO:0035556
IBA
Genome Projectintracellular signal transduction
GO:0043123
ISO, IBA
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777
IDA
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048661
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0051092
IDA
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051259
ISO
IEA
Genome Projectprotein oligomerization
GO:0070498
IDA
ISO
IEA
Genome Projectinterleukin-1-mediated signaling pathway
GO:0070555
ISO
IEA
Genome Projectresponse to interleukin-1
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071456
IEA
Genome Projectcellular response to hypoxia

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA
ISO
IEA
Genome Projectprotein kinase activity
GO:0004674
ISO, IBA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005149
IPI
Genome Projectinterleukin-1 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
ISO
IEA
Genome Projectkinase activity
GO:0031072
IEA
Genome Projectheat shock protein binding
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0046982
ISO
IEA
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISO, IBA
IEA
Genome Projectnucleus
GO:0005737
ISO, IBA
IEA
Genome Projectcytoplasm
GO:0005886
IBA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR011029Death-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.