Gene: ENSMUSG00000030867 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000030867
Transcript Identifier
ENSMUST00000033154
Gene Type
Coding gene
Location
7 : 122159543-122169590 : positive

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
polo-like kinase 1

Identifiers

Type Value
UniprotQ07832
UniprotQ3TPZ2
MGI97621

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000070
ISS, ISO
IEA
Genome Projectmitotic sister chromatid segregation
GO:0000086
ISS, ISO
IEA
Genome ProjectG2/M transition of mitotic cell cycle
GO:0000122
ISS, ISO
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000281
ISS, ISO
IEA
Genome Projectmitotic cytokinesis
GO:0000910
IEA
Genome Projectcytokinesis
GO:0001578
ISS, ISO
IEA
Genome Projectmicrotubule bundle formation
GO:0006468
IMP
ISS, ISO
IEA
Genome Projectprotein phosphorylation
GO:0007049
IEA
Genome Projectcell cycle
GO:0007067
ISS, ISO
IEA
Genome Projectmitotic nuclear division
GO:0007092
ISS, ISO
IEA
Genome Projectactivation of APC-Cdc20 complex activity
GO:0007094
ISS, ISO
IEA
Genome Projectmitotic spindle assembly checkpoint
GO:0007346
ISO
IEA
Genome Projectregulation of mitotic cell cycle
GO:0010800
ISO
IEA
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016321
IMP
Genome Projectfemale meiosis chromosome segregation
GO:0016567
ISO
IEA
Genome Projectprotein ubiquitination
GO:0018105
ISO
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0030071
ISO
IEA
Genome Projectregulation of mitotic metaphase/anaphase transition
GO:0031572
ISS
IEA
Genome ProjectG2 DNA damage checkpoint
GO:0031648
ISO
IEA
Genome Projectprotein destabilization
GO:0032436
ISS, ISO
IEA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066
ISS, ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043393
ISO
IEA
Genome Projectregulation of protein binding
GO:0045143
IMP
Genome Projecthomologous chromosome segregation
GO:0045184
ISO
IEA
Genome Projectestablishment of protein localization
GO:0045736
ISO
IEA
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045862
ISO
IEA
Genome Projectpositive regulation of proteolysis
GO:0051297
ISS, ISO
IEA
Genome Projectcentrosome organization
GO:0051301
IEA
Genome Projectcell division
GO:0051443
ISS, ISO
IEA
Genome Projectpositive regulation of ubiquitin-protein transferase activity
GO:0070194
IMP
Genome Projectsynaptonemal complex disassembly
GO:0071168
ISS, ISO
IEA
Genome Projectprotein localization to chromatin
GO:1901673
ISO
IEA
Genome Projectregulation of mitotic spindle assembly

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
ISO
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
ISS, ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008017
ISS, ISO
IEA
Genome Projectmicrotubule binding
GO:0010997
ISO
IEA
Genome Projectanaphase-promoting complex binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000775
IEA
Genome Projectchromosome, centromeric region
GO:0000776
IDA
ISS, ISO
IEA
Genome Projectkinetochore
GO:0000777
IEA
Genome Projectcondensed chromosome kinetochore
GO:0000780
IDA
Genome Projectcondensed nuclear chromosome, centromeric region
GO:0000785
IDA
Genome Projectchromatin
GO:0000795
IDA
Genome Projectsynaptonemal complex
GO:0000922
ISO
IEA
Genome Projectspindle pole
GO:0000942
ISO
IEA
Genome Projectcondensed nuclear chromosome outer kinetochore
GO:0005634
ISS, ISO
IEA
Genome Projectnucleus
GO:0005694
IEA
Genome Projectchromosome
GO:0005730
ISO
IEA
Genome Projectnucleolus
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005813
ISS, ISO
IEA
Genome Projectcentrosome
GO:0005815
IEA
Genome Projectmicrotubule organizing center
GO:0005819
ISS, ISO
IEA
Genome Projectspindle
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005876
ISO
IEA
Genome Projectspindle microtubule
GO:0015630
ISO
IEA
Genome Projectmicrotubule cytoskeleton
GO:0030496
ISS, ISO
IEA
Genome Projectmidbody
GO:0051233
ISS, ISO
IEA
Genome Projectspindle midzone

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR000959POLO box duplicated domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.