Gene: ENSMUSG00000029521 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000029521
Transcript Identifier
ENSMUST00000066160
Gene Type
Coding gene
Location
5 : 110841213-110873566 : positive

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P017158
(5 genes in 4 species)
specific family

Descriptions

gene_descr
checkpoint kinase 2

Identifiers

Type Value
UniprotQ9Z265
UniprotQ543W6
MGI1355321

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000086
ISS, ISO
IEA
Genome ProjectG2/M transition of mitotic cell cycle
GO:0001302
ISO
IEA
Genome Projectreplicative cell aging
GO:0006302
ISS, ISO
IEA
Genome Projectdouble-strand break repair
GO:0006355
ISS, ISO
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006468
ISO
IEA
Genome Projectprotein phosphorylation
GO:0006915
IMP
IEA
Genome Projectapoptotic process
GO:0006974
ISS, ISO
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0006975
ISS, ISO
IEA
Genome ProjectDNA damage induced protein phosphorylation
GO:0008630
ISS, ISO
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332
IDA
Genome Projectresponse to gamma radiation
GO:0042176
ISS, ISO
IEA
Genome Projectregulation of protein catabolic process
GO:0042770
IDA
ISO
IEA
Genome Projectsignal transduction in response to DNA damage
GO:0044257
ISO
IEA
Genome Projectcellular protein catabolic process
GO:0045893
ISS, ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0046777
ISS, ISO
IEA
Genome Projectprotein autophosphorylation
GO:0050821
ISO
IEA
Genome Projectprotein stabilization
GO:0072428
ISS, ISO
IEA
Genome Projectsignal transduction involved in intra-S DNA damage checkpoint
GO:0090307
ISS, ISO
IEA
Genome Projectmitotic spindle assembly
GO:0006281
IEA
Genome ProjectDNA repair
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0007049
IEA
Genome Projectcell cycle
GO:0007067
IEA
Genome Projectmitotic nuclear division
GO:0016310
IEA
Genome Projectphosphorylation
GO:0051301
IEA
Genome Projectcell division

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
ISS, ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0042803
ISS, ISO
IEA
Genome Projectprotein homodimerization activity
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000781
ISO
IEA
Genome Projectchromosome, telomeric region
GO:0005654
ISO
IEA
Genome Projectnucleoplasm
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0016605
ISS, ISO
IEA
Genome ProjectPML body
GO:0005634
IEA
Genome Projectnucleus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000253Forkhead-associated (FHA) domain
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR008984SMAD/FHA domain
IPR011009Protein kinase-like domain
IPR020636Calcium/calmodulin-dependent/calcium-dependent protein kinase

No MapMan annotations defined for this gene.