Gene: ENSMUSG00000029231 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000029231
Transcript Identifier
ENSMUST00000168162
Gene Type
Coding gene
Location
5 : 75162243-75195100 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
platelet derived growth factor receptor, alpha polypeptide

Identifiers

Type Value
UniprotP26618
MGI97530

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001553
IMP, IGI
Genome Projectluteinization
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0002244
IMP
Genome Projecthematopoietic progenitor cell differentiation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006935
IEA
Genome Projectchemotaxis
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007204
ISS, ISO
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008210
IGI
Genome Projectestrogen metabolic process
GO:0008284
ISS, ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008585
IGI
Genome Projectfemale gonad development
GO:0009653
IMP
Genome Projectanatomical structure morphogenesis
GO:0009725
IEA
Genome Projectresponse to hormone
GO:0009887
IMP
Genome Projectorgan morphogenesis
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010035
IEA
Genome Projectresponse to inorganic substance
GO:0010544
ISS, ISO
IEA
Genome Projectnegative regulation of platelet activation
GO:0010863
ISO
IEA
Genome Projectpositive regulation of phospholipase C activity
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IMP
Genome Projectcell migration
GO:0018108
IDA
ISS, ISO
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0023019
IDA
Genome Projectsignal transduction involved in regulation of gene expression
GO:0030198
IMP
Genome Projectextracellular matrix organization
GO:0030324
IMP
Genome Projectlung development
GO:0030325
IGI
Genome Projectadrenal gland development
GO:0030335
ISS, ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0030539
IMP
Genome Projectmale genitalia development
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0033327
IMP
Genome ProjectLeydig cell differentiation
GO:0034097
IEA
Genome Projectresponse to cytokine
GO:0034614
ISO
Genome Projectcellular response to reactive oxygen species
GO:0035790
IDA
ISO
IEA
Genome Projectplatelet-derived growth factor receptor-alpha signaling pathway
GO:0038091
ISS, ISO
IEA
Genome Projectpositive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042060
IMP
IEA
Genome Projectwound healing
GO:0042063
IEA
Genome Projectgliogenesis
GO:0042475
IMP
Genome Projectodontogenesis of dentin-containing tooth
GO:0043552
ISS, ISO
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045740
ISS, ISO
IEA
Genome Projectpositive regulation of DNA replication
GO:0046777
IDA
ISS, ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048008
IMP
ISO
IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0048015
ISS, ISO
IEA
Genome Projectphosphatidylinositol-mediated signaling
GO:0048146
ISS, ISO
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048557
IMP
Genome Projectembryonic digestive tract morphogenesis
GO:0048701
IMP
Genome Projectembryonic cranial skeleton morphogenesis
GO:0048705
IMP
Genome Projectskeletal system morphogenesis
GO:0048839
IEA
Genome Projectinner ear development
GO:0050920
ISO
IEA
Genome Projectregulation of chemotaxis
GO:0055003
IGI
Genome Projectcardiac myofibril assembly
GO:0055093
IEA
Genome Projectresponse to hyperoxia
GO:0060021
IMP
Genome Projectpalate development
GO:0060325
IMP
Genome Projectface morphogenesis
GO:0060326
IMP
ISO
IEA
Genome Projectcell chemotaxis
GO:0061298
IGI
Genome Projectretina vasculature development in camera-type eye
GO:0070374
ISS, ISO
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070527
ISS, ISO
IEA
Genome Projectplatelet aggregation
GO:0071230
IDA
Genome Projectcellular response to amino acid stimulus
GO:0072277
IGI
Genome Projectmetanephric glomerular capillary formation
GO:2000739
ISS, ISO
IEA
Genome Projectregulation of mesenchymal stem cell differentiation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
ISO
IEA
Genome Projectprotein kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
ISO
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005018
IDA
ISS, ISO
IEA
Genome Projectplatelet-derived growth factor alpha-receptor activity
GO:0005021
ISS, ISO
IEA
Genome Projectvascular endothelial growth factor-activated receptor activity
GO:0005161
ISO
IEA
Genome Projectplatelet-derived growth factor receptor binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0032403
IDA
Genome Projectprotein complex binding
GO:0038085
ISO
IEA
Genome Projectvascular endothelial growth factor binding
GO:0042803
ISS, ISO
IEA
Genome Projectprotein homodimerization activity
GO:0043548
IEA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0048407
IDA
ISO
TAS, IEA
Genome Projectplatelet-derived growth factor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISS
Genome Projectnucleus
GO:0005737
IDA
ISS
Genome Projectcytoplasm
GO:0005829
ISO
Genome Projectcytosol
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005887
ISS, ISO
IEA
Genome Projectintegral component of plasma membrane
GO:0005902
IDA
Genome Projectmicrovillus
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0031226
ISO
IEA
Genome Projectintrinsic component of plasma membrane
GO:0043234
ISO
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001824Tyrosine-protein kinase, receptor class III, conserved site
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR013098Immunoglobulin I-set
IPR013783Immunoglobulin-like fold
IPR016243Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR027290Platelet-derived growth factor receptor alpha

No MapMan annotations defined for this gene.