Gene: ENSMUSG00000028874 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000028874
Transcript Identifier
ENSMUST00000171223
Gene Type
Coding gene
Location
4 : 132986163-133000343 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P005517
(15 genes in 3 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog

Identifiers

Type Value
UniprotP14234
MGI95527

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002376
IEA
Genome Projectimmune system process
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
IBA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229
IMP
ISO
Genome Projectintegrin-mediated signaling pathway
GO:0008360
IMP
Genome Projectregulation of cell shape
GO:0014068
ISO
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
ISO
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030154
IBA
Genome Projectcell differentiation
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0032956
TAS
Genome Projectregulation of actin cytoskeleton organization
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0043306
IDA
Genome Projectpositive regulation of mast cell degranulation
GO:0043552
ISO
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0045087
IBA
IEA
Genome Projectinnate immune response
GO:0045088
IMP
Genome Projectregulation of innate immune response
GO:0045859
IDA
Genome Projectregulation of protein kinase activity
GO:0046777
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0050715
IDA
Genome Projectpositive regulation of cytokine secretion
GO:0050764
IMP
Genome Projectregulation of phagocytosis
GO:0050830
IMP, IGI
Genome Projectdefense response to Gram-positive bacterium
GO:0071375
IBA
Genome Projectcellular response to peptide hormone stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001784
IDA
Genome Projectphosphotyrosine binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IDA
ISO
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
IDA, IPI
Genome Projectprotein kinase binding
GO:0034987
IDA
Genome Projectimmunoglobulin receptor binding
GO:0034988
ISO
IEA
Genome ProjectFc-gamma receptor I complex binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005743
IEA
Genome Projectmitochondrial inner membrane
GO:0005758
IEA
Genome Projectmitochondrial intermembrane space
GO:0005829
IEA
Genome Projectcytosol
GO:0005856
ISO
IEA
Genome Projectcytoskeleton
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0032587
IDA
IEA
Genome Projectruffle membrane
GO:0042995
IEA
Genome Projectcell projection
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0015629
IDA
Genome Projectactin cytoskeleton

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452SH3 domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR028459Tyrosine-protein kinase Fgr

No MapMan annotations defined for this gene.