Gene: ENSMUSG00000028756 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000028756
Transcript Identifier
ENSMUST00000030536
Gene Type
Coding gene
Location
4 : 138313956-138326219 : negative

Family Information

Homologous gene family
HOM03P025570
(3 genes in 3 species)
specific family

Descriptions

gene_descr
PTEN induced putative kinase 1

Identifiers

Type Value
UniprotQ99MQ3
MGI1916193

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000422
ISS, ISO, IBA
IEA
Genome Projectmitophagy
GO:0001934
ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0002082
ISO
IEA
Genome Projectregulation of oxidative phosphorylation
GO:0006468
IDA
ISO
IEA
Genome Projectprotein phosphorylation
GO:0006914
IEA
Genome Projectautophagy
GO:0006950
ISS
IEA
Genome Projectresponse to stress
GO:0006979
ISO
IEA
Genome Projectresponse to oxidative stress
GO:0007005
ISO
IEA
Genome Projectmitochondrion organization
GO:0010310
IMP
Genome Projectregulation of hydrogen peroxide metabolic process
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0010821
ISO
IEA
Genome Projectregulation of mitochondrion organization
GO:0016239
ISO
IEA
Genome Projectpositive regulation of macroautophagy
GO:0016242
ISO
IEA
Genome Projectnegative regulation of macroautophagy
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016567
ISS, ISO
IEA
Genome Projectprotein ubiquitination
GO:0018105
ISO
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0022904
IMP
Genome Projectrespiratory electron transport chain
GO:0031396
ISO
IEA
Genome Projectregulation of protein ubiquitination
GO:0032226
IMP
Genome Projectpositive regulation of synaptic transmission, dopaminergic
GO:0033138
ISO
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033603
IMP
Genome Projectpositive regulation of dopamine secretion
GO:0033605
IMP
Genome Projectpositive regulation of catecholamine secretion
GO:0034599
IMP
ISO
Genome Projectcellular response to oxidative stress
GO:0035307
IMP
Genome Projectpositive regulation of protein dephosphorylation
GO:0035556
IDA
ISO
IEA
Genome Projectintracellular signal transduction
GO:0043123
ISO
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254
ISO
IEA
Genome Projectregulation of protein complex assembly
GO:0043523
IMP
Genome Projectregulation of neuron apoptotic process
GO:0043524
IMP
ISO
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045727
IMP
Genome Projectpositive regulation of translation
GO:0050821
IMP
ISO
IEA
Genome Projectprotein stabilization
GO:0051091
IMP
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051881
ISO
IEA
Genome Projectregulation of mitochondrial membrane potential
GO:0071456
IMP
ISO
IEA
Genome Projectcellular response to hypoxia
GO:0090141
IBA
Genome Projectpositive regulation of mitochondrial fission
GO:0090200
ISO
IEA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0090258
ISO
IEA
Genome Projectnegative regulation of mitochondrial fission
GO:0097237
IMP
Genome Projectcellular response to toxic substance
GO:0098779
ISO
IEA
Genome Projectmitophagy in response to mitochondrial depolarization
GO:1902176
ISO
IEA
Genome Projectnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902902
ISO
IEA
Genome Projectnegative regulation of autophagosome assembly
GO:1902958
IMP
Genome Projectpositive regulation of mitochondrial electron transport, NADH to ubiquinone
GO:1903147
ISO
IEA
Genome Projectnegative regulation of mitophagy
GO:1903202
ISO
IEA
Genome Projectnegative regulation of oxidative stress-induced cell death
GO:1903214
ISO
IEA
Genome Projectregulation of protein targeting to mitochondrion
GO:1903298
IMP
Genome Projectnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO:1903384
ISO
IEA
Genome Projectnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
GO:1903852
ISO
IEA
Genome Projectpositive regulation of cristae formation
GO:1903955
ISO
IEA
Genome Projectpositive regulation of protein targeting to mitochondrion
GO:2000377
ISO
IEA
Genome Projectregulation of reactive oxygen species metabolic process
GO:2000378
ISO
IEA
Genome Projectnegative regulation of reactive oxygen species metabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0000287
IDA
ISO
IEA
Genome Projectmagnesium ion binding
GO:0002020
ISO
IEA
Genome Projectprotease binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA, IMP
ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005524
IDA
ISO
IEA
Genome ProjectATP binding
GO:0010857
ISO
IEA
Genome Projectcalcium-dependent protein kinase activity
GO:0016301
IDA
ISO
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0043422
ISO
IEA
Genome Projectprotein kinase B binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0055131
ISO
IEA
Genome ProjectC3HC4-type RING finger domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000785
ISO
IEA
Genome Projectchromatin
GO:0005634
ISO
IEA
Genome Projectnucleus
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005739
IDA
ISS, ISO
IEA
Genome Projectmitochondrion
GO:0005741
ISO
IEA
Genome Projectmitochondrial outer membrane
GO:0005743
IDA
ISO
IEA
Genome Projectmitochondrial inner membrane
GO:0005758
ISO
IEA
Genome Projectmitochondrial intermembrane space
GO:0005829
ISS, ISO
IEA
Genome Projectcytosol
GO:0005856
ISO
IEA
Genome Projectcytoskeleton
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030424
ISO
IEA
Genome Projectaxon
GO:0031307
ISO
IEA
Genome Projectintegral component of mitochondrial outer membrane
GO:0031932
ISO
IEA
Genome ProjectTORC2 complex
GO:0044297
ISO
IEA
Genome Projectcell body
GO:0048471
ISO
IEA
Genome Projectperinuclear region of cytoplasm
GO:0097449
ISO
IEA
Genome Projectastrocyte projection
GO:0005742
ISO
Genome Projectmitochondrial outer membrane translocase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.