Gene: ENSMUSG00000028163 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000028163
Transcript Identifier
ENSMUST00000164430
Gene Type
Coding gene
Location
3 : 135585355-135667785 : negative

Family Information

Homologous gene family
HOM03P008110
(10 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P071470
(2 genes in 2 species)
specific family

Descriptions

gene_descr
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

Identifiers

Type Value
UniprotP25799
MGI97312

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS, ISO, IBA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001818
IMP
Genome Projectnegative regulation of cytokine production
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006366
ISO
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006954
IBA
Genome Projectinflammatory response
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007249
IBA
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0010956
ISO
IEA
Genome Projectnegative regulation of calcidiol 1-monooxygenase activity
GO:0034097
IBA
Genome Projectresponse to cytokine
GO:0035994
IDA
Genome Projectresponse to muscle stretch
GO:0038061
IBA
Genome ProjectNIK/NF-kappaB signaling
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0045083
IDA
Genome Projectnegative regulation of interleukin-12 biosynthetic process
GO:0045087
IBA
Genome Projectinnate immune response
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
ISS, ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046688
IEA
Genome Projectresponse to copper ion
GO:0048535
TAS
Genome Projectlymph node development
GO:0050728
IMP
Genome Projectnegative regulation of inflammatory response
GO:0071222
ISO
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0071316
ISO
IEA
Genome Projectcellular response to nicotine
GO:0071347
IEA
Genome Projectcellular response to interleukin-1
GO:0071354
ISO
IEA
Genome Projectcellular response to interleukin-6
GO:0071359
IMP
Genome Projectcellular response to dsRNA
GO:0071375
ISO
IEA
Genome Projectcellular response to peptide hormone stimulus
GO:0090263
ISO
IEA
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1900127
ISO
IEA
Genome Projectpositive regulation of hyaluronan biosynthetic process
GO:2000630
ISO
IEA
Genome Projectpositive regulation of miRNA metabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000975
ISS, ISO
IEA
Genome Projectregulatory region DNA binding
GO:0000976
ISO
IEA
Genome Projecttranscription regulatory region sequence-specific DNA binding
GO:0000977
ISO, IBA
IEA
Genome ProjectRNA polymerase II regulatory region sequence-specific DNA binding
GO:0000980
ISO
IEA
Genome ProjectRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981
IBA
Genome ProjectRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001205
ISO
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0001227
ISO
IEA
Genome Projecttranscriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677
IDA
IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003690
IEA
Genome Projectdouble-stranded DNA binding
GO:0003700
ISS, ISO
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IEA
Genome Projecttranscription factor binding
GO:0031072
IEA
Genome Projectheat shock protein binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0042805
ISO
Genome Projectactinin binding
GO:0043565
IDA
IEA
Genome Projectsequence-specific DNA binding
GO:0044212
ISO
IEA
Genome Projecttranscription regulatory region DNA binding
GO:0046982
ISO
IEA
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005654
ISO, IBA
IEA
Genome Projectnucleoplasm
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005739
ISO
IEA
Genome Projectmitochondrion
GO:0005829
IDA
IEA
Genome Projectcytosol
GO:0033256
IBA
Genome ProjectI-kappaB/NF-kappaB complex
GO:0043234
IEA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000451NF-kappa-B/Dorsal
IPR000488Death domain
IPR002110Ankyrin repeat
IPR002909IPT domain
IPR008967p53-like transcription factor, DNA-binding
IPR011029Death-like domain
IPR011539Rel homology domain (RHD), DNA-binding domain
IPR013783Immunoglobulin-like fold
IPR014756Immunoglobulin E-set
IPR020683Ankyrin repeat-containing domain
IPR030492Rel homology domain, conserved site
IPR030503Nuclear factor NF-kappa-B, p105 subunit
IPR032397Rel homology dimerisation domain

No MapMan annotations defined for this gene.