Gene: ENSMUSG00000028059 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000028059
Transcript Identifier
ENSMUST00000029694
Gene Type
Coding gene
Location
3 : 88621259-88646863 : positive

Family Information

Homologous gene family
HOM03P004874
(19 genes in 5 species)
specific family
Orthologous gene family
ORTHO03P069421
(2 genes in 2 species)
specific family

Descriptions

gene_descr
rho/rac guanine nucleotide exchange factor (GEF) 2

Identifiers

Type Value
UniprotQ60875
MGI103264

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000132
IMP
Genome Projectestablishment of mitotic spindle orientation
GO:0000902
IDA
ISS, ISO
IEA
Genome Projectcell morphogenesis
GO:0002376
IEA
Genome Projectimmune system process
GO:0007015
IPI
ISS, ISO
IEA
Genome Projectactin filament organization
GO:0007026
ISS, ISO
IEA
Genome Projectnegative regulation of microtubule depolymerization
GO:0007049
IEA
Genome Projectcell cycle
GO:0007067
IEA
Genome Projectmitotic nuclear division
GO:0032755
ISS, ISO
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032760
ISS, ISO
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0035023
IDA
IEA
Genome Projectregulation of Rho protein signal transduction
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0043547
ISO
Genome Projectpositive regulation of GTPase activity
GO:0045087
IEA
Genome Projectinnate immune response
GO:0045944
ISS, ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050731
ISS, ISO
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050768
IMP
Genome Projectnegative regulation of neurogenesis
GO:0051092
ISS, ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051301
IEA
Genome Projectcell division
GO:0071225
ISS, ISO
IEA
Genome Projectcellular response to muramyl dipeptide

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005085
IEA
Genome Projectguanyl-nucleotide exchange factor activity
GO:0005089
IDA
ISS, ISO
IEA
Genome ProjectRho guanyl-nucleotide exchange factor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008017
IDA
ISS, ISO
IEA
Genome Projectmicrotubule binding
GO:0017048
ISS, ISO
IEA
Genome ProjectRho GTPase binding
GO:0030676
ISS, ISO
IEA
Genome ProjectRac guanyl-nucleotide exchange factor activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0048365
ISS, ISO
IEA
Genome ProjectRac GTPase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISS, ISO
IEA
Genome Projectcytoplasm
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005819
IEA
Genome Projectspindle
GO:0005856
ISS, ISO
IEA
Genome Projectcytoskeleton
GO:0005874
ISS, ISO
IEA
Genome Projectmicrotubule
GO:0005923
IEA
Genome Projectbicellular tight junction
GO:0005925
ISO
IEA
Genome Projectfocal adhesion
GO:0016023
IEA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0030054
IEA
Genome Projectcell junction
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0031982
ISS, ISO
IEA
Genome Projectvesicle
GO:0032587
ISS, ISO
IEA
Genome Projectruffle membrane
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043198
IDA
Genome Projectdendritic shaft
GO:0043234
ISS, ISO
IEA
Genome Projectprotein complex
GO:0097481
IDA
Genome Projectneuronal postsynaptic density

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000219Dbl homology (DH) domain
IPR001849Pleckstrin homology domain
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR011993PH domain-like

No MapMan annotations defined for this gene.