Gene: ENSMUSG00000027996 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000027996
Transcript Identifier
ENSMUST00000029625
Gene Type
Coding gene
Location
3 : 83766542-83773422 : positive

Family Information

Homologous gene family
HOM03P002165
(40 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P074891
(2 genes in 2 species)
specific family

Descriptions

gene_descr
secreted frizzled-related protein 2

Identifiers

Type Value
UniprotP97299
UniprotQ3UI35
MGI108078

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001569
IDA
Genome Projectpatterning of blood vessels
GO:0001756
IGI
Genome Projectsomitogenesis
GO:0001843
IGI
Genome Projectneural tube closure
GO:0002063
IMP
Genome Projectchondrocyte development
GO:0003151
ISO
IEA
Genome Projectoutflow tract morphogenesis
GO:0003214
ISO
IEA
Genome Projectcardiac left ventricle morphogenesis
GO:0006915
IMP
Genome Projectapoptotic process
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007584
IEA
Genome Projectresponse to nutrient
GO:0008284
IDA
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008584
IGI
Genome Projectmale gonad development
GO:0009952
IGI
Genome Projectanterior/posterior pattern specification
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0010667
IDA
Genome Projectnegative regulation of cardiac muscle cell apoptotic process
GO:0010719
ISO
IEA
Genome Projectnegative regulation of epithelial to mesenchymal transition
GO:0010950
IDA
Genome Projectpositive regulation of endopeptidase activity
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0021915
IGI
Genome Projectneural tube development
GO:0030111
IDA
Genome Projectregulation of Wnt signaling pathway
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030178
IDA
ISO
IEA
Genome Projectnegative regulation of Wnt signaling pathway
GO:0030199
IMP
Genome Projectcollagen fibril organization
GO:0030307
IDA
Genome Projectpositive regulation of cell growth
GO:0030308
ISO
IEA
Genome Projectnegative regulation of cell growth
GO:0030336
IDA
Genome Projectnegative regulation of cell migration
GO:0030514
IDA, IGI
Genome Projectnegative regulation of BMP signaling pathway
GO:0031668
IDA
Genome Projectcellular response to extracellular stimulus
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0035413
IDA
Genome Projectpositive regulation of catenin import into nucleus
GO:0036342
IMP
Genome Projectpost-anal tail morphogenesis
GO:0042127
IMP
Genome Projectregulation of cell proliferation
GO:0042493
IDA
Genome Projectresponse to drug
GO:0042662
IGI
Genome Projectnegative regulation of mesodermal cell fate specification
GO:0042733
IMP
Genome Projectembryonic digit morphogenesis
GO:0042981
IMP
Genome Projectregulation of apoptotic process
GO:0043065
ISO
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043154
IDA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043508
IGI
Genome Projectnegative regulation of JUN kinase activity
GO:0045600
ISO
IEA
Genome Projectpositive regulation of fat cell differentiation
GO:0045669
IGI
Genome Projectpositive regulation of osteoblast differentiation
GO:0045766
IDA
Genome Projectpositive regulation of angiogenesis
GO:0045892
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046546
IGI
Genome Projectdevelopment of primary male sexual characteristics
GO:0048546
IGI
Genome Projectdigestive tract morphogenesis
GO:0050680
ISO
IEA
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050732
IDA
Genome Projectnegative regulation of peptidyl-tyrosine phosphorylation
GO:0051216
IMP
Genome Projectcartilage development
GO:0060028
IGI
Genome Projectconvergent extension involved in axis elongation
GO:0060070
IBA
Genome Projectcanonical Wnt signaling pathway
GO:0060349
IMP
Genome Projectbone morphogenesis
GO:0061056
IEP
Genome Projectsclerotome development
GO:0061185
IDA
Genome Projectnegative regulation of dermatome development
GO:0071425
IDA
Genome Projecthematopoietic stem cell proliferation
GO:0071481
IDA
Genome Projectcellular response to X-ray
GO:0090090
IDA, IGI
ISO
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090175
IGI
Genome Projectregulation of establishment of planar polarity
GO:0090179
IGI
Genome Projectplanar cell polarity pathway involved in neural tube closure
GO:0090244
IGI
Genome ProjectWnt signaling pathway involved in somitogenesis
GO:0090263
IDA, IGI
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1902042
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000035
IDA
Genome Projectregulation of stem cell division
GO:2000041
IGI
Genome Projectnegative regulation of planar cell polarity pathway involved in axis elongation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0010577
IDA
Genome Projectmetalloenzyme activator activity
GO:0017147
IPI
Genome ProjectWnt-protein binding
GO:0048018
IDA
Genome Projectreceptor agonist activity
GO:0061133
IDA
Genome Projectendopeptidase activator activity
GO:0004930
IBA
Genome ProjectG-protein coupled receptor activity
GO:0042813
IBA
Genome ProjectWnt-activated receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
ISO
Genome Projectextracellular space
GO:0016021
IBA
Genome Projectintegral component of membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001134Netrin domain
IPR008993Tissue inhibitor of metalloproteinases-like, OB-fold
IPR015526Frizzled/secreted frizzled-related protein
IPR018933Netrin module, non-TIMP type
IPR020067Frizzled domain
IPR026558Secreted frizzled-related protein 2

No MapMan annotations defined for this gene.