Gene: ENSMUSG00000027995 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000027995
Transcript Identifier
ENSMUST00000029623
Gene Type
Coding gene
Location
3 : 83836420-83838774 : negative

Family Information

Homologous gene family
HOM03P004593
(20 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P067303
(2 genes in 2 species)
specific family

Descriptions

gene_descr
toll-like receptor 2

Identifiers

Type Value
UniprotG3X8Y8
MGI1346060

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002224
IEA
Genome Projecttoll-like receptor signaling pathway
GO:0002237
IEA
Genome Projectresponse to molecule of bacterial origin
GO:0002238
IMP
Genome Projectresponse to molecule of fungal origin
GO:0002374
ISO
IEA
Genome Projectcytokine secretion involved in immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0002687
IMP
Genome Projectpositive regulation of leukocyte migration
GO:0002730
IDA
Genome Projectregulation of dendritic cell cytokine production
GO:0002752
IMP
Genome Projectcell surface pattern recognition receptor signaling pathway
GO:0002755
IGI
IEA
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007252
ISO
IEA
Genome ProjectI-kappaB phosphorylation
GO:0009617
IMP
Genome Projectresponse to bacterium
GO:0010628
ISO
Genome Projectpositive regulation of gene expression
GO:0030177
ISO
IEA
Genome Projectpositive regulation of Wnt signaling pathway
GO:0032494
IMP
Genome Projectresponse to peptidoglycan
GO:0032613
ISO
IEA
Genome Projectinterleukin-10 production
GO:0032695
IMP
Genome Projectnegative regulation of interleukin-12 production
GO:0032700
IMP
Genome Projectnegative regulation of interleukin-17 production
GO:0032722
IMP
ISO
IEA
Genome Projectpositive regulation of chemokine production
GO:0032755
IDA, IMP
ISO
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032757
ISO
IEA
Genome Projectpositive regulation of interleukin-8 production
GO:0032760
IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0034123
ISO
IEA
Genome Projectpositive regulation of toll-like receptor signaling pathway
GO:0034134
IEA
Genome Projecttoll-like receptor 2 signaling pathway
GO:0042346
ISO
IEA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042495
ISO
IEA
Genome Projectdetection of triacyl bacterial lipopeptide
GO:0042496
ISO
IEA
Genome Projectdetection of diacyl bacterial lipopeptide
GO:0042535
IMP
Genome Projectpositive regulation of tumor necrosis factor biosynthetic process
GO:0042892
IMP
Genome Projectchloramphenicol transport
GO:0044130
IMP
Genome Projectnegative regulation of growth of symbiont in host
GO:0045087
IEA
Genome Projectinnate immune response
GO:0045429
IMP
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0050707
IEA
Genome Projectregulation of cytokine secretion
GO:0050715
IGI
Genome Projectpositive regulation of cytokine secretion
GO:0050729
IEA
Genome Projectpositive regulation of inflammatory response
GO:0050830
IMP
ISO
IEA
Genome Projectdefense response to Gram-positive bacterium
GO:0051092
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0052063
IMP
Genome Projectinduction by symbiont of defense-related host nitric oxide production
GO:0060907
IMP
Genome Projectpositive regulation of macrophage cytokine production
GO:0071221
IMP
Genome Projectcellular response to bacterial lipopeptide
GO:0071223
IMP
ISO
IEA
Genome Projectcellular response to lipoteichoic acid
GO:0071224
IMP
Genome Projectcellular response to peptidoglycan
GO:0071726
ISO
IEA
Genome Projectcellular response to diacyl bacterial lipopeptide
GO:0071727
ISO
IEA
Genome Projectcellular response to triacyl bacterial lipopeptide

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004872
ISO
IEA
Genome Projectreceptor activity
GO:0004888
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0008329
ISO
IEA
Genome Projectsignaling pattern recognition receptor activity
GO:0042497
IDA
ISO
IEA
Genome Projecttriacyl lipopeptide binding
GO:0042498
IDA
Genome Projectdiacyl lipopeptide binding
GO:0042834
ISO
IEA
Genome Projectpeptidoglycan binding
GO:0046982
IPI
ISO
IEA
Genome Projectprotein heterodimerization activity
GO:0070891
IDA
Genome Projectlipoteichoic acid binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005886
IDA
ISO
IEA
Genome Projectplasma membrane
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0035354
ISO
IEA
Genome ProjectToll-like receptor 1-Toll-like receptor 2 protein complex
GO:0035355
IPI
Genome ProjectToll-like receptor 2-Toll-like receptor 6 protein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000157Toll/interleukin-1 receptor homology (TIR) domain
IPR000483Cysteine-rich flanking region, C-terminal
IPR001611Leucine-rich repeat
IPR003591Leucine-rich repeat, typical subtype
IPR017241Toll-like receptor
IPR027185Toll-like receptor 2

No MapMan annotations defined for this gene.