Gene: ENSMUSG00000027947 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000027947
Transcript Identifier
ENSMUST00000029559
Gene Type
Coding gene
Location
3 : 89871161-89913039 : negative

Family Information

Homologous gene family
HOM03P007870
(11 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P071255
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 6 receptor, alpha

Identifiers

Type Value
UniprotP22272
MGI105304

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008284
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0010536
ISO
IEA
Genome Projectpositive regulation of activation of Janus kinase activity
GO:0016049
IEA
Genome Projectcell growth
GO:0019221
ISO
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0031018
ISO
Genome Projectendocrine pancreas development
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032722
ISO
IEA
Genome Projectpositive regulation of chemokine production
GO:0032755
ISO
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032966
ISO
IEA
Genome Projectnegative regulation of collagen biosynthetic process
GO:0034097
ISO
IEA
Genome Projectresponse to cytokine
GO:0042517
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043410
ISO
IEA
Genome Projectpositive regulation of MAPK cascade
GO:0043434
IEA
Genome Projectresponse to peptide hormone
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0046427
IEA
Genome Projectpositive regulation of JAK-STAT cascade
GO:0048661
ISO
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050731
ISO
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051591
IEA
Genome Projectresponse to cAMP
GO:0070102
IDA
ISO
IEA
Genome Projectinterleukin-6-mediated signaling pathway
GO:0070120
ISO
IEA
Genome Projectciliary neurotrophic factor-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004896
IEA
Genome Projectcytokine receptor activity
GO:0004897
ISO
IEA
Genome Projectciliary neurotrophic factor receptor activity
GO:0004915
IDA
ISO
IEA
Genome Projectinterleukin-6 receptor activity
GO:0005138
ISO
IEA
Genome Projectinterleukin-6 receptor binding
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0019981
IDA
ISO
IEA
Genome Projectinterleukin-6 binding
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0070119
ISO
IEA
Genome Projectciliary neurotrophic factor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
ISO
IEA
Genome Projectextracellular region
GO:0005615
ISO
IEA
Genome Projectextracellular space
GO:0005896
ISO
IEA
Genome Projectinterleukin-6 receptor complex
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016324
ISO
IEA
Genome Projectapical plasma membrane
GO:0032809
IEA
Genome Projectneuronal cell body membrane
GO:0070110
ISO
IEA
Genome Projectciliary neurotrophic factor receptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003530Long hematopoietin receptor, soluble alpha chain, conserved site
IPR003598Immunoglobulin subtype 2
IPR003961Fibronectin type III
IPR007110Immunoglobulin-like domain
IPR013151Immunoglobulin
IPR013783Immunoglobulin-like fold
IPR015321Type I cytokine receptor, cytokine-binding domain

No MapMan annotations defined for this gene.