Gene: ENSMUSG00000027776 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000027776
Transcript Identifier
ENSMUST00000029345
Gene Type
Coding gene
Location
3 : 68690739-68698050 : positive

Family Information

Homologous gene family
HOM03P032956
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 12a

Identifiers

Type Value
UniprotF8WI71
MGI96539

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001916
ISO
Genome Projectpositive regulation of T cell mediated cytotoxicity
GO:0002860
ISO
Genome Projectpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0006955
IEA
Genome Projectimmune response
GO:0007050
ISO
Genome Projectcell cycle arrest
GO:0010224
ISO
Genome Projectresponse to UV-B
GO:0016477
ISO
Genome Projectcell migration
GO:0032496
ISO
Genome Projectresponse to lipopolysaccharide
GO:0032700
ISO
Genome Projectnegative regulation of interleukin-17 production
GO:0032729
IGI
ISO
Genome Projectpositive regulation of interferon-gamma production
GO:0032816
ISO
Genome Projectpositive regulation of natural killer cell activation
GO:0032946
ISO
Genome Projectpositive regulation of mononuclear cell proliferation
GO:0034393
ISO
Genome Projectpositive regulation of smooth muscle cell apoptotic process
GO:0042102
IDA
Genome Projectpositive regulation of T cell proliferation
GO:0042520
ISO
Genome Projectpositive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042832
IDA, IGI
Genome Projectdefense response to protozoan
GO:0045582
IGI
Genome Projectpositive regulation of T cell differentiation
GO:0045785
ISO
Genome Projectpositive regulation of cell adhesion
GO:0045954
ISO
Genome Projectpositive regulation of natural killer cell mediated cytotoxicity
GO:0048662
ISO
Genome Projectnegative regulation of smooth muscle cell proliferation
GO:0050671
ISO
Genome Projectpositive regulation of lymphocyte proliferation
GO:0051135
ISO
Genome Projectpositive regulation of NK T cell activation
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0097191
ISO
Genome Projectextrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005143
IBA
IEA
Genome Projectinterleukin-12 receptor binding
GO:0008083
ISO
IEA
Genome Projectgrowth factor activity
GO:0042163
IPI
ISO
Genome Projectinterleukin-12 beta subunit binding
GO:0045513
ISO
Genome Projectinterleukin-27 binding
GO:0046982
ISO
Genome Projectprotein heterodimerization activity
GO:0005125
IDA
ISO
Genome Projectcytokine activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
ISO
Genome Projectextracellular space
GO:0005737
IDA
Genome Projectcytoplasm
GO:0043514
IDA, IGI
ISO
Genome Projectinterleukin-12 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004281Interleukin-12 alpha
IPR009079Four-helical cytokine-like, core
IPR012351Four-helical cytokine, core

No MapMan annotations defined for this gene.