Gene: ENSMUSG00000027665 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000027665
Transcript Identifier
ENSMUST00000029201
Gene Type
Coding gene
Location
3 : 32436206-32462831 : positive

Family Information

Homologous gene family
HOM03P000138
(215 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P004415
(19 genes in 9 species)
specific family

Descriptions

gene_descr
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide

Identifiers

Type Value
UniprotP42337
MGI1206581

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001889
IMP
Genome Projectliver development
GO:0002250
IBA
Genome Projectadaptive immune response
GO:0006006
IMP
Genome Projectglucose metabolic process
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0006954
IBA
Genome Projectinflammatory response
GO:0014065
IBA
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0030168
IBA
Genome Projectplatelet activation
GO:0032147
IDA
Genome Projectactivation of protein kinase activity
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0036092
IDA
ISO
IEA
Genome Projectphosphatidylinositol-3-phosphate biosynthetic process
GO:0040014
IMP
Genome Projectregulation of multicellular organism growth
GO:0043457
IMP
Genome Projectregulation of cellular respiration
GO:0043491
IMP
Genome Projectprotein kinase B signaling
GO:0043524
IMP
Genome Projectnegative regulation of neuron apoptotic process
GO:0044029
IDA
Genome Projecthypomethylation of CpG island
GO:0045087
IBA
Genome Projectinnate immune response
GO:0046854
IBA
IEA
Genome Projectphosphatidylinositol phosphorylation
GO:0048015
IEA
Genome Projectphosphatidylinositol-mediated signaling
GO:0060326
IBA
Genome Projectcell chemotaxis
GO:0060612
IMP
Genome Projectadipose tissue development
GO:0071333
IMP
Genome Projectcellular response to glucose stimulus
GO:0097009
IMP
Genome Projectenergy homeostasis
GO:0098779
ISO
Genome Projectmitophagy in response to mitochondrial depolarization
GO:1903146
IEA
Genome Projectregulation of mitophagy
GO:2000270
IDA
Genome Projectnegative regulation of fibroblast apoptotic process
GO:2000653
IDA
Genome Projectregulation of genetic imprinting
GO:2000811
ISO
IEA
Genome Projectnegative regulation of anoikis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016303
IDA
ISO
IEA
Genome Project1-phosphatidylinositol-3-kinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0016773
IEA
Genome Projectphosphotransferase activity, alcohol group as acceptor
GO:0030295
IDA
Genome Projectprotein kinase activator activity
GO:0035005
IBA
Genome Project1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560
IPI
Genome Projectinsulin receptor substrate binding
GO:0046934
IEA
Genome Projectphosphatidylinositol-4,5-bisphosphate 3-kinase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IBA
Genome Projectcytoplasm
GO:0005886
IBA
Genome Projectplasma membrane
GO:0005942
IPI
Genome Projectphosphatidylinositol 3-kinase complex
GO:0005943
ISO, IBA
IEA
Genome Projectphosphatidylinositol 3-kinase complex, class IA
GO:0030027
IDA
Genome Projectlamellipodium

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000008C2 domain
IPR000341Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420Phosphatidylinositol 3-kinase, C2 domain
IPR003113Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR011009Protein kinase-like domain
IPR015433Phosphatidylinositol Kinase
IPR016024Armadillo-type fold
IPR018936Phosphatidylinositol 3/4-kinase, conserved site
IPR029071Ubiquitin-related domain

No MapMan annotations defined for this gene.