Gene: ENSMUSG00000027646 (Mus musculus)

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Gene Identifier
ENSMUSG00000027646
Transcript Identifier
ENSMUST00000109529
Gene Type
Coding gene
Location
2 : 157457085-157469961 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P005517
(15 genes in 3 species)
specific family

Descriptions

gene_descr
Rous sarcoma oncogene

Identifiers

Type Value
UniprotP05480
MGI98397

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002376
IEA
Genome Projectimmune system process
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0007049
IEA
Genome Projectcell cycle
GO:0007155
IEA
Genome Projectcell adhesion
GO:0007173
IBA
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007179
ISO
IEA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007229
ISO
IEA
Genome Projectintegrin-mediated signaling pathway
GO:0010632
ISO
IEA
Genome Projectregulation of epithelial cell migration
GO:0010634
ISO
Genome Projectpositive regulation of epithelial cell migration
GO:0016310
IMP
IEA
Genome Projectphosphorylation
GO:0016477
IMP
Genome Projectcell migration
GO:0018108
IDA
ISO
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0022407
ISO
IEA
Genome Projectregulation of cell-cell adhesion
GO:0030154
IBA
Genome Projectcell differentiation
GO:0030900
IGI
Genome Projectforebrain development
GO:0031648
IMP
Genome Projectprotein destabilization
GO:0032463
ISO
IEA
Genome Projectnegative regulation of protein homooligomerization
GO:0033146
IMP
Genome Projectregulation of intracellular estrogen receptor signaling pathway
GO:0034446
IDA
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0034614
IDA
Genome Projectcellular response to reactive oxygen species
GO:0035556
IGI
ISO
IEA
Genome Projectintracellular signal transduction
GO:0036035
IGI
Genome Projectosteoclast development
GO:0036120
IDA
Genome Projectcellular response to platelet-derived growth factor stimulus
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043149
ISO
IEA
Genome Projectstress fiber assembly
GO:0043154
ISO
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393
IDA
Genome Projectregulation of protein binding
GO:0045087
IBA
Genome Projectinnate immune response
GO:0045453
IMP
Genome Projectbone resorption
GO:0046777
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048477
IMP
Genome Projectoogenesis
GO:0050847
IBA
Genome Projectprogesterone receptor signaling pathway
GO:0051726
IBA
Genome Projectregulation of cell cycle
GO:0051897
ISO
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051902
ISO
IEA
Genome Projectnegative regulation of mitochondrial depolarization
GO:0060065
IMP
Genome Projectuterus development
GO:0060444
IMP
Genome Projectbranching involved in mammary gland duct morphogenesis
GO:0060491
IGI
Genome Projectregulation of cell projection assembly
GO:0070374
IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070555
ISO
IEA
Genome Projectresponse to interleukin-1
GO:0071375
IGI
Genome Projectcellular response to peptide hormone stimulus
GO:0071498
IMP
Genome Projectcellular response to fluid shear stress
GO:0071560
IGI
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0071803
IDA, IGI
Genome Projectpositive regulation of podosome assembly
GO:0086098
IGI
Genome Projectangiotensin-activated signaling pathway involved in heart process
GO:0090263
IGI
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:2000394
ISO
Genome Projectpositive regulation of lamellipodium morphogenesis
GO:2000641
ISO
IEA
Genome Projectregulation of early endosome to late endosome transport
GO:2000811
ISO
IEA
Genome Projectnegative regulation of anoikis
GO:2001237
ISO, IBA
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway
GO:2001243
ISO, IBA
IEA
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway
GO:2001286
ISO
IEA
Genome Projectregulation of caveolin-mediated endocytosis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IDA, IMP
ISO
IEA
Genome Projectprotein kinase activity
GO:0004713
IMP
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IBA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005102
ISO
IEA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IMP
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0020037
ISS, ISO
IEA
Genome Projectheme binding
GO:0042169
ISO
IEA
Genome ProjectSH2 domain binding
GO:0044325
ISO
IEA
Genome Projection channel binding
GO:0046875
IPI
ISO
IEA
Genome Projectephrin receptor binding
GO:0051219
ISO
IEA
Genome Projectphosphoprotein binding
GO:0051427
IBA
Genome Projecthormone receptor binding
GO:0070851
ISO, IBA
IEA
Genome Projectgrowth factor receptor binding
GO:0097110
IPI
ISO
IEA
Genome Projectscaffold protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005739
ISO
IEA
Genome Projectmitochondrion
GO:0005743
ISO
IEA
Genome Projectmitochondrial inner membrane
GO:0005764
ISO
IEA
Genome Projectlysosome
GO:0005770
ISO
IEA
Genome Projectlate endosome
GO:0005829
ISO
TAS, IEA
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005884
IDA
Genome Projectactin filament
GO:0005886
IDA
ISO
IEA
Genome Projectplasma membrane
GO:0005901
IDA
ISO
IEA
Genome Projectcaveola
GO:0016020
IEA
Genome Projectmembrane
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0032587
IDA
Genome Projectruffle membrane
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452SH3 domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.