Gene: ENSMUSG00000027598 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000027598
Transcript Identifier
ENSMUST00000109685
Gene Type
Coding gene
Location
2 : 155163414-155224466 : positive

Family Information

Homologous gene family
HOM03P000060
(418 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P003574
(23 genes in 8 species)
specific family

Descriptions

gene_descr
itchy, E3 ubiquitin protein ligase

Identifiers

Type Value
UniprotQ8C863
MGI1202301

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000209
IDA
Genome Projectprotein polyubiquitination
GO:0002376
IEA
Genome Projectimmune system process
GO:0002669
IMP
Genome Projectpositive regulation of T cell anergy
GO:0006511
IDA
ISA
IEA
Genome Projectubiquitin-dependent protein catabolic process
GO:0006915
IEA
Genome Projectapoptotic process
GO:0016567
ISS, ISO
IEA
Genome Projectprotein ubiquitination
GO:0032088
IMP
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0035519
ISS, ISO
IEA
Genome Projectprotein K29-linked ubiquitination
GO:0042787
IDA
Genome Projectprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066
ISS, ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0045087
IEA
Genome Projectinnate immune response
GO:0045732
IDA, IMP
Genome Projectpositive regulation of protein catabolic process
GO:0046329
IMP
Genome Projectnegative regulation of JNK cascade
GO:0046642
IMP
Genome Projectnegative regulation of alpha-beta T cell proliferation
GO:0050687
IMP
ISO
IEA
Genome Projectnegative regulation of defense response to virus
GO:0051607
IEA
Genome Projectdefense response to virus
GO:0070534
ISS, ISO
IEA
Genome Projectprotein K63-linked ubiquitination
GO:0070936
IMP
ISS, ISO
IEA
Genome Projectprotein K48-linked ubiquitination
GO:0090085
IMP
Genome Projectregulation of protein deubiquitination

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
ISS, ISO, IBA
IEA
Genome Projectubiquitin-protein transferase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016874
IMP
IEA
Genome Projectligase activity
GO:0043021
ISO
IEA
Genome Projectribonucleoprotein complex binding
GO:0045236
ISO
IEA
Genome ProjectCXCR chemokine receptor binding
GO:0061630
ISA
IEA
Genome Projectubiquitin protein ligase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000151
ISA
Genome Projectubiquitin ligase complex
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
ISO
IEA
Genome Projectplasma membrane
GO:0005938
IDA
Genome Projectcell cortex
GO:0016020
IDA
ISO
IEA
Genome Projectmembrane
GO:0031410
IDA
Genome Projectcytoplasmic vesicle
GO:0070062
ISO
IEA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000008C2 domain
IPR000569HECT domain
IPR001202WW domain
IPR024928E3 ubiquitin-protein ligase, SMURF1 type

No MapMan annotations defined for this gene.