Gene: ENSMUSG00000027399 (Mus musculus)

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Gene Identifier
ENSMUSG00000027399
Transcript Identifier
ENSMUST00000028882
Gene Type
Coding gene
Location
2 : 129300711-129309101 : negative

Family Information

Homologous gene family
HOM03P048263
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 1 alpha

Identifiers

Type Value
UniprotP01582
UniprotQ3U0Y6
MGI96542

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001660
IBA
IEA
Genome Projectfever generation
GO:0002248
IMP
Genome Projectconnective tissue replacement involved in inflammatory response wound healing
GO:0002437
IBA
Genome Projectinflammatory response to antigenic stimulus
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0008285
ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0010575
IMP
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010628
ISO
Genome Projectpositive regulation of gene expression
GO:0019221
ISO, IBA
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0034605
ISS, ISO
IEA
Genome Projectcellular response to heat
GO:0035234
IGI
Genome Projectectopic germ cell programmed cell death
GO:0043123
IBA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045086
ISO
IEA
Genome Projectpositive regulation of interleukin-2 biosynthetic process
GO:0045766
IMP
Genome Projectpositive regulation of angiogenesis
GO:0045840
ISO
IEA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045944
IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046330
IBA
Genome Projectpositive regulation of JNK cascade
GO:0046688
ISS, ISO
IEA
Genome Projectresponse to copper ion
GO:0050714
ISO
Genome Projectpositive regulation of protein secretion
GO:0050715
ISO
IEA
Genome Projectpositive regulation of cytokine secretion
GO:0051781
IEA
Genome Projectpositive regulation of cell division
GO:0070374
IBA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0097192
IMP
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
ISO, IBA
IEA
Genome Projectcytokine activity
GO:0005149
IBA
IEA
Genome Projectinterleukin-1 receptor binding
GO:0005507
ISS, ISO
IEA
Genome Projectcopper ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
ISS, ISO
IEA
Genome Projectextracellular space
GO:0005829
ISS, ISO
IEA
Genome Projectcytosol

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000975Interleukin-1 family
IPR003294Interleukin-1 alpha/beta
IPR003295Interleukin-1 alpha
IPR003502Interleukin-1 propeptide
IPR008996Cytokine, IL-1-like
IPR020877Interleukin-1 conserved site

No MapMan annotations defined for this gene.