Gene: ENSMUSG00000027347 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000027347
Transcript Identifier
ENSMUST00000178884
Gene Type
Coding gene
Location
2 : 117282542-117342709 : negative

Family Information

Homologous gene family
HOM03P008763
(9 genes in 3 species)
specific family

Descriptions

gene_descr
RAS guanyl releasing protein 1

Identifiers

Type Value
UniprotQ9Z1S3
MGI1314635

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001816
IMP
Genome Projectcytokine production
GO:0001934
ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0002437
IMP
Genome Projectinflammatory response to antigenic stimulus
GO:0007264
IEA
Genome Projectsmall GTPase mediated signal transduction
GO:0007265
IEA
Genome ProjectRas protein signal transduction
GO:0014066
IMP
Genome Projectregulation of phosphatidylinositol 3-kinase signaling
GO:0030154
IEA
Genome Projectcell differentiation
GO:0032252
IMP
Genome Projectsecretory granule localization
GO:0032725
ISO
Genome Projectpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032760
ISO
Genome Projectpositive regulation of tumor necrosis factor production
GO:0032816
IMP
Genome Projectpositive regulation of natural killer cell activation
GO:0032825
IMP
Genome Projectpositive regulation of natural killer cell differentiation
GO:0033089
IMP
Genome Projectpositive regulation of T cell differentiation in thymus
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0043087
IEA
Genome Projectregulation of GTPase activity
GO:0043303
IMP
Genome Projectmast cell degranulation
GO:0043406
ISO
IEA
Genome Projectpositive regulation of MAP kinase activity
GO:0043547
ISO
Genome Projectpositive regulation of GTPase activity
GO:0045954
ISO
Genome Projectpositive regulation of natural killer cell mediated cytotoxicity
GO:0046330
ISO
Genome Projectpositive regulation of JNK cascade
GO:0046579
ISO
Genome Projectpositive regulation of Ras protein signal transduction
GO:0047496
IMP
Genome Projectvesicle transport along microtubule
GO:0051259
ISO
Genome Projectprotein oligomerization
GO:0070372
ISO
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0070374
ISO
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0090630
IMP
ISO
IEA
Genome Projectactivation of GTPase activity
GO:1902715
ISO
Genome Projectpositive regulation of interferon-gamma secretion

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001786
ISO
Genome Projectphosphatidylserine binding
GO:0005085
IEA
Genome Projectguanyl-nucleotide exchange factor activity
GO:0005088
ISO
Genome ProjectRas guanyl-nucleotide exchange factor activity
GO:0005509
ISO
IEA
Genome Projectcalcium ion binding
GO:0008270
ISO
Genome Projectzinc ion binding
GO:0019992
ISO
Genome Projectdiacylglycerol binding
GO:0031210
ISO
Genome Projectphosphatidylcholine binding
GO:0042803
ISO
Genome Projectprotein homodimerization activity
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
IEA
Genome ProjectGolgi membrane
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005794
ISO
IEA
Genome ProjectGolgi apparatus
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0042629
IMP
Genome Projectmast cell granule

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000651Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895Ras guanine-nucleotide exchange factors catalytic domain
IPR002048EF-hand domain
IPR002219Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR011992EF-hand domain pair
IPR018247EF-Hand 1, calcium-binding site
IPR020454Diacylglycerol/phorbol-ester binding
IPR023578Ras guanine nucleotide exchange factor domain
IPR029647Ras guanyl-releasing protein 1

No MapMan annotations defined for this gene.