Gene: ENSMUSG00000026942 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000026942
Transcript Identifier
ENSMUST00000114234
Gene Type
Coding gene
Location
2 : 25519410-25539053 : negative

Family Information

Homologous gene family
HOM03P005260
(17 genes in 6 species)
specific family
Orthologous gene family
ORTHO03P073636
(2 genes in 2 species)
specific family

Descriptions

gene_descr
TNF receptor-associated factor 2

Identifiers

Type Value
UniprotP39429
MGI101835

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002726
ISO
IEA
Genome Projectpositive regulation of T cell cytokine production
GO:0006461
IEA
Genome Projectprotein complex assembly
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007165
IDA
IEA
Genome Projectsignal transduction
GO:0007250
ISO
IEA
Genome Projectactivation of NF-kappaB-inducing kinase activity
GO:0016567
IEA
Genome Projectprotein ubiquitination
GO:0030163
IMP
Genome Projectprotein catabolic process
GO:0032743
ISO
IEA
Genome Projectpositive regulation of interleukin-2 production
GO:0033209
ISS, ISO
IEA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034351
IEA
Genome Projectnegative regulation of glial cell apoptotic process
GO:0042981
ISS, ISO
IEA
Genome Projectregulation of apoptotic process
GO:0043066
NAS
Genome Projectnegative regulation of apoptotic process
GO:0043123
IDA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507
ISS, ISO
IEA
Genome Projectpositive regulation of JUN kinase activity
GO:0043623
IDA
Genome Projectcellular protein complex assembly
GO:0046328
IDA
IEA
Genome Projectregulation of JNK cascade
GO:0051023
IMP
Genome Projectregulation of immunoglobulin secretion
GO:0051091
ISO
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092
IDA, IMP
ISO
IEA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0051865
ISS, ISO
IEA
Genome Projectprotein autoubiquitination
GO:0070207
ISO
IEA
Genome Projectprotein homotrimerization
GO:0070534
ISS, ISO
IEA
Genome Projectprotein K63-linked ubiquitination
GO:0071732
IMP
Genome Projectcellular response to nitric oxide
GO:0090073
ISO
IEA
Genome Projectpositive regulation of protein homodimerization activity
GO:0097300
IMP
Genome Projectprogrammed necrotic cell death
GO:1903265
IDA
Genome Projectpositive regulation of tumor necrosis factor-mediated signaling pathway
GO:1903721
IDA
Genome Projectpositive regulation of I-kappaB phosphorylation
GO:2001238
ISO
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
ISS, ISO
IEA
Genome Projectubiquitin-protein transferase activity
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005164
ISO
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0005174
IPI
Genome ProjectCD40 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0016874
IEA
Genome Projectligase activity
GO:0019899
ISO
IEA
Genome Projectenzyme binding
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding
GO:0019903
ISO
IEA
Genome Projectprotein phosphatase binding
GO:0031435
IEA
Genome Projectmitogen-activated protein kinase kinase kinase binding
GO:0031625
ISO
IEA
Genome Projectubiquitin protein ligase binding
GO:0031996
ISO
IEA
Genome Projectthioesterase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0042802
ISO
IEA
Genome Projectidentical protein binding
GO:0046625
ISS, ISO
IEA
Genome Projectsphingolipid binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000151
ISO
IEA
Genome Projectubiquitin ligase complex
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005829
IDA
Genome Projectcytosol
GO:0005938
IEA
Genome Projectcell cortex
GO:0009898
IDA
Genome Projectcytoplasmic side of plasma membrane
GO:0012506
IDA
Genome Projectvesicle membrane
GO:0035631
IDA
Genome ProjectCD40 receptor complex
GO:0043234
IEA
Genome Projectprotein complex
GO:0045121
IDA
IEA
Genome Projectmembrane raft
GO:0097057
ISO
IEA
Genome ProjectTRAF2-GSTP1 complex
GO:1990604
IDA
ISO
IEA
Genome ProjectIRE1-TRAF2-ASK1 complex
GO:1990597
IPI
Genome ProjectAIP1-IRE1 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001293Zinc finger, TRAF-type
IPR001841Zinc finger, RING-type
IPR002083MATH/TRAF domain
IPR008974TRAF-like
IPR012227TNF receptor-associated factor TRAF
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR017907Zinc finger, RING-type, conserved site
IPR018957Zinc finger, C3HC4 RING-type
IPR027133TNF receptor-associated factor 2
IPR032070TNF receptor-associated factor, BIRC3 binding domain

No MapMan annotations defined for this gene.