Gene: ENSMUSG00000026700 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000026700
Transcript Identifier
ENSMUST00000028024
Gene Type
Coding gene
Location
1 : 161395582-161417338 : positive

Family Information

Homologous gene family
HOM03P046525
(2 genes in 2 species)
specific family

Descriptions

gene_descr
tumor necrosis factor (ligand) superfamily, member 4

Identifiers

Type Value
UniprotP43488
UniprotB6DXE3
MGI104511

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001816
IEA
Genome Projectcytokine production
GO:0006954
IPI
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0008203
IMP
Genome Projectcholesterol metabolic process
GO:0032700
ISS, ISO
IEA
Genome Projectnegative regulation of interleukin-17 production
GO:0032729
IMP
ISO
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032743
IEA
Genome Projectpositive regulation of interleukin-2 production
GO:0032753
IDA, IMP
ISO
IEA
Genome Projectpositive regulation of interleukin-4 production
GO:0032755
IMP
ISO
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0042098
IEA
Genome ProjectT cell proliferation
GO:0042104
IEA
Genome Projectpositive regulation of activated T cell proliferation
GO:0050710
IPI
Genome Projectnegative regulation of cytokine secretion
GO:0050729
ISS, ISO
IEA
Genome Projectpositive regulation of inflammatory response
GO:0071222
ISS, ISO
NAS, IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071380
ISS, ISO
IEA
Genome Projectcellular response to prostaglandin E stimulus
GO:0001568
NAS
Genome Projectblood vessel development
GO:0002215
IMP
Genome Projectdefense response to nematode
GO:0002526
IMP
Genome Projectacute inflammatory response
GO:0002699
TAS
Genome Projectpositive regulation of immune effector process
GO:0002726
IDA
Genome Projectpositive regulation of T cell cytokine production
GO:0002819
IDA
Genome Projectregulation of adaptive immune response
GO:0002830
IDA, IMP
Genome Projectpositive regulation of type 2 immune response
GO:0002891
IMP
Genome Projectpositive regulation of immunoglobulin mediated immune response
GO:0009615
IDA
Genome Projectresponse to virus
GO:0032689
IDA
Genome Projectnegative regulation of interferon-gamma production
GO:0032733
IMP
Genome Projectpositive regulation of interleukin-10 production
GO:0032735
IMP
Genome Projectpositive regulation of interleukin-12 production
GO:0032736
IDA
Genome Projectpositive regulation of interleukin-13 production
GO:0035709
IMP
Genome Projectmemory T cell activation
GO:0035712
IMP
Genome ProjectT-helper 2 cell activation
GO:0035713
IDA
Genome Projectresponse to nitrogen dioxide
GO:0035714
IMP
Genome Projectcellular response to nitrogen dioxide
GO:0035783
IDA
Genome ProjectCD4-positive, alpha-beta T cell costimulation
GO:0043372
IDA
Genome Projectpositive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043382
IDA
Genome Projectpositive regulation of memory T cell differentiation
GO:0043433
IDA
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087
NAS
Genome Projectinnate immune response
GO:0045590
IMP
Genome Projectnegative regulation of regulatory T cell differentiation
GO:0045626
IDA
Genome Projectnegative regulation of T-helper 1 cell differentiation
GO:0045630
IDA
Genome Projectpositive regulation of T-helper 2 cell differentiation
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0046641
IMP
Genome Projectpositive regulation of alpha-beta T cell proliferation
GO:0050727
IDA
Genome Projectregulation of inflammatory response
GO:0050871
IDA
Genome Projectpositive regulation of B cell activation
GO:0051024
IDA
Genome Projectpositive regulation of immunoglobulin secretion
GO:0070233
IC
Genome Projectnegative regulation of T cell apoptotic process
GO:0070236
IC
Genome Projectnegative regulation of activation-induced cell death of T cells
GO:0071954
IMP
Genome Projectchemokine (C-C motif) ligand 11 production
GO:1900281
IDA
Genome Projectpositive regulation of CD4-positive, alpha-beta T cell costimulation
GO:2000406
NAS
Genome Projectpositive regulation of T cell migration
GO:2000525
IDA
Genome Projectpositive regulation of T cell costimulation
GO:2000568
IMP
Genome Projectpositive regulation of memory T cell activation
GO:2000570
IMP
Genome Projectpositive regulation of T-helper 2 cell activation
GO:2000572
IMP
Genome Projectpositive regulation of interleukin-4-dependent isotype switching to IgE isotypes
GO:2001237
IC
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
IEA
Genome Projectcytokine activity
GO:0005164
IPI
IEA
Genome Projecttumor necrosis factor receptor binding
GO:0032813
IPI
IEA
Genome Projecttumor necrosis factor receptor superfamily binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
ISS, ISO
IEA
Genome Projectextracellular space
GO:0009986
ISS, ISO
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR006052Tumour necrosis factor domain
IPR008983Tumour necrosis factor-like domain
IPR021184Tumour necrosis factor, conserved site

No MapMan annotations defined for this gene.