Gene: ENSMUSG00000026029 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000026029
Transcript Identifier
ENSMUST00000190213
Gene Type
Coding gene
Location
1 : 58804083-58846754 : positive

Family Information

Homologous gene family
HOM03P003300
(30 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P069733
(2 genes in 2 species)
specific family

Descriptions

gene_descr
caspase 8

Identifiers

Type Value
UniprotA0A087WQT6
MGI1261423

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001525
IMP
Genome Projectangiogenesis
GO:0001841
IMP
Genome Projectneural tube formation
GO:0006508
ISO
IEA
Genome Projectproteolysis
GO:0006915
IDA
ISO
IEA
Genome Projectapoptotic process
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007507
IMP
Genome Projectheart development
GO:0008625
IMP
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0030225
IMP
Genome Projectmacrophage differentiation
GO:0034612
ISO
Genome Projectresponse to tumor necrosis factor
GO:0036462
ISO
Genome ProjectTRAIL-activated apoptotic signaling pathway
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043123
ISO
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
ISO
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045651
ISO
Genome Projectpositive regulation of macrophage differentiation
GO:0045862
ISO
Genome Projectpositive regulation of proteolysis
GO:0051603
ISO
Genome Projectproteolysis involved in cellular protein catabolic process
GO:0060546
IGI
Genome Projectnegative regulation of necroptotic process
GO:0070243
IGI
Genome Projectregulation of thymocyte apoptotic process
GO:0097190
IDA
ISO
Genome Projectapoptotic signaling pathway
GO:0097191
IDA, IGI
ISO
Genome Projectextrinsic apoptotic signaling pathway
GO:0097194
ISO
Genome Projectexecution phase of apoptosis
GO:0097202
ISO
Genome Projectactivation of cysteine-type endopeptidase activity
GO:0097284
IMP
Genome Projecthepatocyte apoptotic process
GO:2001233
IGI
Genome Projectregulation of apoptotic signaling pathway
GO:2001238
IGI
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004175
IDA, IMP
Genome Projectendopeptidase activity
GO:0004197
IDA, IGI
ISO
IEA
Genome Projectcysteine-type endopeptidase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IDA, IMP
ISO
IEA
Genome Projectpeptidase activity
GO:0008234
IEA
Genome Projectcysteine-type peptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0031625
ISO
Genome Projectubiquitin protein ligase binding
GO:0035877
ISO, IBA
Genome Projectdeath effector domain binding
GO:0046982
IPI
Genome Projectprotein heterodimerization activity
GO:0097110
ISO
Genome Projectscaffold protein binding
GO:0097153
IDA
ISO
Genome Projectcysteine-type endopeptidase activity involved in apoptotic process
GO:0097199
ISO, IBA
Genome Projectcysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
Genome Projectnucleus
GO:0005654
ISO
Genome Projectnucleoplasm
GO:0005737
IDA
ISO
Genome Projectcytoplasm
GO:0005739
IDA
ISO
Genome Projectmitochondrion
GO:0005815
ISO
Genome Projectmicrotubule organizing center
GO:0005829
ISO
Genome Projectcytosol
GO:0030690
IMP
Genome ProjectNoc1p-Noc2p complex
GO:0031264
ISO
Genome Projectdeath-inducing signaling complex
GO:0031265
ISO
Genome ProjectCD95 death-inducing signaling complex
GO:0097342
ISO
Genome Projectripoptosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001309Peptidase C14, ICE, catalytic subunit p20
IPR001875Death effector domain
IPR002138Peptidase C14, caspase non-catalytic subunit p10
IPR011029Death-like domain
IPR011600Peptidase C14, caspase domain
IPR015917Peptidase C14A, caspase precursor p45, core
IPR016129Peptidase C14, ICE, catalytic subunit p20, active site
IPR029030Caspase-like domain

No MapMan annotations defined for this gene.