Gene: ENSMUSG00000025889 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000025889
Transcript Identifier
ENSMUST00000114268
Gene Type
Coding gene
Location
6 : 60732129-60827601 : negative

Family Information

Homologous gene family
HOM03P013223
(6 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P071193
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
synuclein, alpha

Identifiers

Type Value
UniprotO55042
MGI1277151

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001774
IMP
Genome Projectmicroglial cell activation
GO:0001921
ISO
IEA
Genome Projectpositive regulation of receptor recycling
GO:0001933
IEA
Genome Projectnegative regulation of protein phosphorylation
GO:0001956
IDA
Genome Projectpositive regulation of neurotransmitter secretion
GO:0001963
IMP
Genome Projectsynaptic transmission, dopaminergic
GO:0006631
IMP
Genome Projectfatty acid metabolic process
GO:0006638
IMP
Genome Projectneutral lipid metabolic process
GO:0006644
IMP
Genome Projectphospholipid metabolic process
GO:0006919
ISO
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006
IMP
Genome Projectmitochondrial membrane organization
GO:0007268
IGI
Genome Projectsynaptic transmission
GO:0007568
IEA
Genome Projectaging
GO:0008344
IGI
Genome Projectadult locomotory behavior
GO:0010040
ISO
IEA
Genome Projectresponse to iron(II) ion
GO:0010517
ISO
IEA
Genome Projectregulation of phospholipase activity
GO:0010642
ISO
IEA
Genome Projectnegative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048
IMP
Genome Projectregulation of glutamate secretion
GO:0014059
IGI
TAS, IEA
Genome Projectregulation of dopamine secretion
GO:0031115
ISO
IEA
Genome Projectnegative regulation of microtubule polymerization
GO:0031623
ISO
IEA
Genome Projectreceptor internalization
GO:0031648
ISO
IEA
Genome Projectprotein destabilization
GO:0032026
ISO
IEA
Genome Projectresponse to magnesium ion
GO:0032410
ISO
IEA
Genome Projectnegative regulation of transporter activity
GO:0032496
ISO
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032769
ISO
IEA
Genome Projectnegative regulation of monooxygenase activity
GO:0033138
IMP
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0034341
ISO
IEA
Genome Projectresponse to interferon-gamma
GO:0034599
IMP
Genome Projectcellular response to oxidative stress
GO:0035067
ISO
IEA
Genome Projectnegative regulation of histone acetylation
GO:0040012
IMP
Genome Projectregulation of locomotion
GO:0042220
IEA
Genome Projectresponse to cocaine
GO:0042416
IMP
Genome Projectdopamine biosynthetic process
GO:0042417
IGI
Genome Projectdopamine metabolic process
GO:0042493
IMP
Genome Projectresponse to drug
GO:0042775
IMP
Genome Projectmitochondrial ATP synthesis coupled electron transport
GO:0043030
IMP
Genome Projectregulation of macrophage activation
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043154
ISO
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524
IGI
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0044344
IEA
Genome Projectcellular response to fibroblast growth factor stimulus
GO:0045807
ISO
IEA
Genome Projectpositive regulation of endocytosis
GO:0045920
ISO
IEA
Genome Projectnegative regulation of exocytosis
GO:0045963
IEA
Genome Projectnegative regulation of dopamine metabolic process
GO:0046928
IMP, IGI
Genome Projectregulation of neurotransmitter secretion
GO:0048148
IEA
Genome Projectbehavioral response to cocaine
GO:0048168
IMP
Genome Projectregulation of neuronal synaptic plasticity
GO:0048169
IMP
Genome Projectregulation of long-term neuronal synaptic plasticity
GO:0048488
IMP
Genome Projectsynaptic vesicle endocytosis
GO:0048489
IMP
Genome Projectsynaptic vesicle transport
GO:0050806
IMP
Genome Projectpositive regulation of synaptic transmission
GO:0050808
IGI
Genome Projectsynapse organization
GO:0050812
IDA, IMP
Genome Projectregulation of acyl-CoA biosynthetic process
GO:0051281
ISO
IEA
Genome Projectpositive regulation of release of sequestered calcium ion into cytosol
GO:0051585
ISO
IEA
Genome Projectnegative regulation of dopamine uptake involved in synaptic transmission
GO:0051612
ISO
IEA
Genome Projectnegative regulation of serotonin uptake
GO:0051622
ISO
IEA
Genome Projectnegative regulation of norepinephrine uptake
GO:0055114
ISO
IEA
Genome Projectoxidation-reduction process
GO:0060079
IMP
Genome Projectexcitatory postsynaptic potential
GO:0060291
IMP
Genome Projectlong-term synaptic potentiation
GO:0060732
ISO
IEA
Genome Projectpositive regulation of inositol phosphate biosynthetic process
GO:0061024
IMP
Genome Projectmembrane organization
GO:0070495
ISO
IEA
Genome Projectnegative regulation of thrombin receptor signaling pathway
GO:0070555
ISO
IEA
Genome Projectresponse to interleukin-1
GO:0071280
ISO
IEA
Genome Projectcellular response to copper ion
GO:0071902
ISO
IEA
Genome Projectpositive regulation of protein serine/threonine kinase activity
GO:1901214
IEA
Genome Projectregulation of neuron death
GO:1903284
ISO
IEA
Genome Projectpositive regulation of glutathione peroxidase activity
GO:1903285
ISO
IEA
Genome Projectpositive regulation of hydrogen peroxide catabolic process
GO:2000377
IMP
Genome Projectregulation of reactive oxygen species metabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000287
ISO
IEA
Genome Projectmagnesium ion binding
GO:0005507
ISS, ISO
IEA
Genome Projectcopper ion binding
GO:0005509
ISO
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005543
ISO
IEA
Genome Projectphospholipid binding
GO:0008017
IEA
Genome Projectmicrotubule binding
GO:0008198
ISO
IEA
Genome Projectferrous iron binding
GO:0008270
ISO
IEA
Genome Projectzinc ion binding
GO:0016491
ISO
IEA
Genome Projectoxidoreductase activity
GO:0019894
ISO
IEA
Genome Projectkinesin binding
GO:0019899
IEA
Genome Projectenzyme binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0030544
IEA
Genome ProjectHsp70 protein binding
GO:0042393
IDA
ISO
IEA
Genome Projecthistone binding
GO:0042802
IDA
ISO
IEA
Genome Projectidentical protein binding
GO:0043014
ISO
IEA
Genome Projectalpha-tubulin binding
GO:0043027
ISO
IEA
Genome Projectcysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043274
IEA
Genome Projectphospholipase binding
GO:0045502
ISO
IEA
Genome Projectdynein binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0047485
IEA
Genome Projectprotein N-terminus binding
GO:0048156
ISO
IEA
Genome Projecttau protein binding
GO:0048487
IEA
Genome Projectbeta-tubulin binding
GO:0050544
IDA
Genome Projectarachidonic acid binding
GO:0051219
ISO
IEA
Genome Projectphosphoprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
ISS, ISO
Genome Projectextracellular space
GO:0005634
IDA
ISO
IEA
Genome Projectnucleus
GO:0005640
IEA
Genome Projectnuclear outer membrane
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005791
IEA
Genome Projectrough endoplasmic reticulum
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005829
IDA
ISO
IEA
Genome Projectcytosol
GO:0005840
IEA
Genome Projectribosome
GO:0005856
IDA
Genome Projectcytoskeleton
GO:0005886
IDA
ISO
IEA
Genome Projectplasma membrane
GO:0005938
ISO
IEA
Genome Projectcell cortex
GO:0008021
IEA
Genome Projectsynaptic vesicle
GO:0015629
ISO
IEA
Genome Projectactin cytoskeleton
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016234
IDA
ISO
IEA
Genome Projectinclusion body
GO:0030054
IEA
Genome Projectcell junction
GO:0030424
ISO
IEA
Genome Projectaxon
GO:0030426
ISO
IEA
Genome Projectgrowth cone
GO:0030659
IEA
Genome Projectcytoplasmic vesicle membrane
GO:0031092
ISO
IEA
Genome Projectplatelet alpha granule membrane
GO:0043195
IEA
Genome Projectterminal bouton
GO:0043205
ISO
IEA
Genome Projectfibril
GO:0043231
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0043679
IEA
Genome Projectaxon terminus
GO:0045202
IDA
IEA
Genome Projectsynapse
GO:0048471
ISO
IEA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001058Synuclein
IPR002460Alpha-synuclein

No MapMan annotations defined for this gene.