Gene: ENSMUSG00000025888 (Mus musculus)

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Gene Identifier
ENSMUSG00000025888
Transcript Identifier
ENSMUST00000027015
Gene Type
Coding gene
Location
9 : 5298717-5306768 : positive

Family Information

Homologous gene family
HOM03P003300
(30 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P067346
(2 genes in 2 species)
specific family

Descriptions

gene_descr
caspase 1

Identifiers

Type Value
UniprotP29452
MGI96544

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
IMP
Genome Projectresponse to hypoxia
GO:0006508
ISO
IEA
Genome Projectproteolysis
GO:0006915
IBA
IEA
Genome Projectapoptotic process
GO:0009617
IMP
Genome Projectresponse to bacterium
GO:0010506
IMP
Genome Projectregulation of autophagy
GO:0016485
IDA, IMP
Genome Projectprotein processing
GO:0032496
IDA
Genome Projectresponse to lipopolysaccharide
GO:0032611
IGI
Genome Projectinterleukin-1 beta production
GO:0033198
IMP
Genome Projectresponse to ATP
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043123
IDA
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050715
IMP
Genome Projectpositive regulation of cytokine secretion
GO:0050717
IMP
Genome Projectpositive regulation of interleukin-1 alpha secretion
GO:0050718
IMP
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0050727
IMP
Genome Projectregulation of inflammatory response
GO:0051882
IMP
Genome Projectmitochondrial depolarization
GO:0060081
IMP
Genome Projectmembrane hyperpolarization
GO:0070269
IMP
Genome Projectpyroptosis
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0071310
ISO
IEA
Genome Projectcellular response to organic substance
GO:0097300
IDA
Genome Projectprogrammed necrotic cell death
GO:1901998
IMP
Genome Projecttoxin transport
GO:0097194
IBA
Genome Projectexecution phase of apoptosis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004175
ISO
IEA
Genome Projectendopeptidase activity
GO:0004197
IEA
Genome Projectcysteine-type endopeptidase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IDA
IEA
Genome Projectpeptidase activity
GO:0008234
IEA
Genome Projectcysteine-type peptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0097200
IBA
Genome Projectcysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
Genome Projectextracellular region
GO:0005737
TAS, IEA
Genome Projectcytoplasm
GO:0005739
IMP
Genome Projectmitochondrion
GO:0005829
TAS
Genome Projectcytosol
GO:0072557
IDA
Genome ProjectIPAF inflammasome complex
GO:0072558
ISS, ISO
IEA
Genome ProjectNLRP1 inflammasome complex
GO:0072559
ISS, ISO, IBA
IEA
Genome ProjectNLRP3 inflammasome complex
GO:0097169
ISS, ISO, IBA
IEA
Genome ProjectAIM2 inflammasome complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001309Peptidase C14, ICE, catalytic subunit p20
IPR001315CARD domain
IPR002138Peptidase C14, caspase non-catalytic subunit p10
IPR011029Death-like domain
IPR011600Peptidase C14, caspase domain
IPR015917Peptidase C14A, caspase precursor p45, core
IPR016129Peptidase C14, ICE, catalytic subunit p20, active site
IPR017350Peptidase C14A, Casp1-type
IPR029030Caspase-like domain

No MapMan annotations defined for this gene.