Gene: ENSMUSG00000025746 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000025746
Transcript Identifier
ENSMUST00000026845
Gene Type
Coding gene
Location
5 : 30013192-30019548 : positive

Family Information

Homologous gene family
HOM03P034495
(2 genes in 2 species)
specific family

Descriptions

gene_descr
interleukin 6

Identifiers

Type Value
UniprotP08505
UniprotA2RTD1
MGI96559

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001781
IDA, IMP
ISO
IEA
Genome Projectneutrophil apoptotic process
GO:0001878
IEA
Genome Projectresponse to yeast
GO:0002675
ISO
IEA
Genome Projectpositive regulation of acute inflammatory response
GO:0006469
IEA
Genome Projectnegative regulation of protein kinase activity
GO:0006954
ISO
IEA
Genome Projectinflammatory response
GO:0006955
IEA
Genome Projectimmune response
GO:0007568
IEA
Genome Projectaging
GO:0008284
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008360
IEA
Genome Projectregulation of cell shape
GO:0009408
IEA
Genome Projectresponse to heat
GO:0009409
IEA
Genome Projectresponse to cold
GO:0009611
IDA
IEA
Genome Projectresponse to wounding
GO:0009612
IEA
Genome Projectresponse to mechanical stimulus
GO:0009617
IEA
Genome Projectresponse to bacterium
GO:0010574
ISO
IEA
Genome Projectregulation of vascular endothelial growth factor production
GO:0010628
IGI
IEA
Genome Projectpositive regulation of gene expression
GO:0010996
IEA
Genome Projectresponse to auditory stimulus
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016049
IEA
Genome Projectcell growth
GO:0019221
ISO
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0031000
IEA
Genome Projectresponse to caffeine
GO:0031175
ISO
IEA
Genome Projectneuron projection development
GO:0031667
IEA
Genome Projectresponse to nutrient levels
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032722
ISO
IEA
Genome Projectpositive regulation of chemokine production
GO:0032755
ISO
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032868
IEA
Genome Projectresponse to insulin
GO:0032966
ISO
IEA
Genome Projectnegative regulation of collagen biosynthetic process
GO:0033138
ISO
IEA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0033160
IEA
Genome Projectpositive regulation of protein import into nucleus, translocation
GO:0034097
IEA
Genome Projectresponse to cytokine
GO:0042060
IEA
Genome Projectwound healing
GO:0042102
ISO
IEA
Genome Projectpositive regulation of T cell proliferation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042517
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043065
ISO
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043154
IEA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043200
IEA
Genome Projectresponse to amino acid
GO:0043410
ISO
IEA
Genome Projectpositive regulation of MAPK cascade
GO:0045188
IEA
Genome Projectregulation of circadian sleep/wake cycle, non-REM sleep
GO:0045429
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045454
IEA
Genome Projectcell redox homeostasis
GO:0045666
IEA
Genome Projectpositive regulation of neuron differentiation
GO:0045721
IEA
Genome Projectnegative regulation of gluconeogenesis
GO:0045727
ISO
IEA
Genome Projectpositive regulation of translation
GO:0045740
IEA
Genome Projectpositive regulation of DNA replication
GO:0045893
IDA
ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IGI
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046427
ISO
IEA
Genome Projectpositive regulation of JAK-STAT cascade
GO:0046677
IEA
Genome Projectresponse to antibiotic
GO:0046849
IEA
Genome Projectbone remodeling
GO:0048635
IEA
Genome Projectnegative regulation of muscle organ development
GO:0048661
ISO
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050710
IEA
Genome Projectnegative regulation of cytokine secretion
GO:0050731
ISO
IEA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050871
ISO
IEA
Genome Projectpositive regulation of B cell activation
GO:0051024
ISO
IEA
Genome Projectpositive regulation of immunoglobulin secretion
GO:0051091
ISO
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384
ISO
IEA
Genome Projectresponse to glucocorticoid
GO:0051592
IEA
Genome Projectresponse to calcium ion
GO:0051602
IEA
Genome Projectresponse to electrical stimulus
GO:0051607
ISO
IEA
Genome Projectdefense response to virus
GO:0051897
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0051971
IEA
Genome Projectpositive regulation of transmission of nerve impulse
GO:0070102
IDA
ISO
IEA
Genome Projectinterleukin-6-mediated signaling pathway
GO:0070301
ISO
IEA
Genome Projectcellular response to hydrogen peroxide
GO:0070374
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071222
IDA
ISO
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071347
IDA
IEA
Genome Projectcellular response to interleukin-1
GO:0071356
IDA
IEA
Genome Projectcellular response to tumor necrosis factor
GO:0071549
IEA
Genome Projectcellular response to dexamethasone stimulus
GO:1901215
IEA
Genome Projectnegative regulation of neuron death
GO:0002262
IMP
Genome Projectmyeloid cell homeostasis
GO:0002384
ISO
Genome Projecthepatic immune response
GO:0006953
IEA
Genome Projectacute-phase response
GO:0031018
IMP
Genome Projectendocrine pancreas development
GO:0042110
IGI
Genome ProjectT cell activation
GO:0042127
IGI
Genome Projectregulation of cell proliferation
GO:0042593
IGI
Genome Projectglucose homeostasis
GO:0042832
IMP
Genome Projectdefense response to protozoan
GO:0042981
IMP
Genome Projectregulation of apoptotic process
GO:0045079
IDA, IMP
Genome Projectnegative regulation of chemokine biosynthetic process
GO:0045630
IDA
Genome Projectpositive regulation of T-helper 2 cell differentiation
GO:0046716
IGI
Genome Projectmuscle cell cellular homeostasis
GO:0046888
IDA
Genome Projectnegative regulation of hormone secretion
GO:0050679
IDA, IMP
Genome Projectpositive regulation of epithelial cell proliferation
GO:0060445
IDA, IMP
Genome Projectbranching involved in salivary gland morphogenesis
GO:0060664
IDA
Genome Projectepithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091
IMP
Genome Projectglucagon secretion
GO:0072540
IMP
Genome ProjectT-helper 17 cell lineage commitment

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005125
IDA
ISO
IEA
Genome Projectcytokine activity
GO:0005138
IDA
ISO
IEA
Genome Projectinterleukin-6 receptor binding
GO:0008083
ISO
IEA
Genome Projectgrowth factor activity
GO:0005515
IPI
Genome Projectprotein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
ISO
IEA
Genome Projectextracellular space
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005896
ISO
IEA
Genome Projectinterleukin-6 receptor complex
GO:0009897
IDA
Genome Projectexternal side of plasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003574Interleukin-6
IPR009079Four-helical cytokine-like, core
IPR012351Four-helical cytokine, core
IPR030473Interleukin-6/GCSF/MGF, conserved site
IPR030474Interleukin-6/GCSF/MGF

No MapMan annotations defined for this gene.