Gene: ENSMUSG00000025473 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000025473
Transcript Identifier
ENSMUST00000106069
Gene Type
Coding gene
Location
7 : 139979477-139992471 : negative

Family Information

Homologous gene family
HOM03P000979
(63 genes in 13 species)
specific family
Orthologous gene family
ORTHO03P008446
(10 genes in 9 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
a disintegrin and metallopeptidase domain 8

Identifiers

Type Value
UniprotQ05910
UniprotQ3U1J7
MGI107825

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000902
IMP
Genome Projectcell morphogenesis
GO:0001525
IDA
Genome Projectangiogenesis
GO:0002523
IMP
Genome Projectleukocyte migration involved in inflammatory response
GO:0002675
IMP
Genome Projectpositive regulation of acute inflammatory response
GO:0002693
IMP
Genome Projectpositive regulation of cellular extravasation
GO:0006508
IEA
Genome Projectproteolysis
GO:0006954
ISO
IEA
Genome Projectinflammatory response
GO:0007160
TAS
Genome Projectcell-matrix adhesion
GO:0016337
IDA
Genome Projectsingle organismal cell-cell adhesion
GO:0022407
ISS, ISO
IEA
Genome Projectregulation of cell-cell adhesion
GO:0033089
IDA
Genome Projectpositive regulation of T cell differentiation in thymus
GO:0035419
IDA
Genome Projectactivation of MAPK activity involved in innate immune response
GO:0043524
IDA
Genome Projectnegative regulation of neuron apoptotic process
GO:0043534
NAS
Genome Projectblood vessel endothelial cell migration
GO:0045670
NAS
Genome Projectregulation of osteoclast differentiation
GO:0045780
IDA, IMP
Genome Projectpositive regulation of bone resorption
GO:0045785
IDA
Genome Projectpositive regulation of cell adhesion
GO:0048247
IDA
Genome Projectlymphocyte chemotaxis
GO:0048729
TAS
Genome Projecttissue morphogenesis
GO:0050729
IDA
Genome Projectpositive regulation of inflammatory response
GO:0051044
IDA
ISO
IEA
Genome Projectpositive regulation of membrane protein ectodomain proteolysis
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0061025
TAS
Genome Projectmembrane fusion
GO:0070245
IMP
Genome Projectpositive regulation of thymocyte apoptotic process
GO:0071456
ISS, ISO
IEA
Genome Projectcellular response to hypoxia
GO:0072675
TAS
Genome Projectosteoclast fusion
GO:2000309
IMP
Genome Projectpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000391
ISO
IEA
Genome Projectpositive regulation of neutrophil extravasation
GO:2000399
NAS
Genome Projectnegative regulation of thymocyte aggregation
GO:2000406
IMP
Genome Projectpositive regulation of T cell migration
GO:2000415
IMP
Genome Projectpositive regulation of fibronectin-dependent thymocyte migration
GO:2000418
IMP
Genome Projectpositive regulation of eosinophil migration
GO:0007229
IEA
Genome Projectintegrin-mediated signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004222
IEA
Genome Projectmetalloendopeptidase activity
GO:0005178
TAS
Genome Projectintegrin binding
GO:0005509
IDA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0008237
IDA
ISO
IEA
Genome Projectmetallopeptidase activity
GO:0008270
IDA
IEA
Genome Projectzinc ion binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0050839
IPI
ISO
IEA
Genome Projectcell adhesion molecule binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002102
ISS, ISO
TAS, IEA
Genome Projectpodosome
GO:0005737
ISS, ISO
IEA
Genome Projectcytoplasm
GO:0005886
IDA
ISO
IEA
Genome Projectplasma membrane
GO:0005887
ISS, ISO
IEA
Genome Projectintegral component of plasma membrane
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0032010
ISS, ISO
IEA
Genome Projectphagolysosome
GO:0032127
ISS, ISO
IEA
Genome Projectdense core granule membrane
GO:0042581
ISS, ISO
IEA
Genome Projectspecific granule
GO:0070820
ISS, ISO
IEA
Genome Projecttertiary granule
GO:0071065
ISS, ISO
IEA
Genome Projectalpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071133
IDA
Genome Projectalpha9-beta1 integrin-ADAM8 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000742EGF-like domain
IPR001590Peptidase M12B, ADAM/reprolysin
IPR001762Disintegrin domain
IPR002870Peptidase M12B, propeptide
IPR006586ADAM, cysteine-rich
IPR013032EGF-like, conserved site
IPR018358Disintegrin, conserved site
IPR024079Metallopeptidase, catalytic domain

No MapMan annotations defined for this gene.