Gene: ENSMUSG00000024789 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000024789
Transcript Identifier
ENSMUST00000025705
Gene Type
Coding gene
Location
19 : 29262208-29311848 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P011898
(7 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
Janus kinase 2

Identifiers

Type Value
UniprotG5E852
MGI96629

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000186
IEA
Genome Projectactivation of MAPKK activity
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007167
IDA
Genome Projectenzyme linked receptor protein signaling pathway
GO:0007169
IBA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007204
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007259
IDA, IMP
IEA
Genome ProjectJAK-STAT cascade
GO:0007260
IDA, IMP
Genome Projecttyrosine phosphorylation of STAT protein
GO:0007262
IDA
Genome ProjectSTAT protein import into nucleus
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IMP
Genome Projectnegative regulation of cell proliferation
GO:0008631
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009755
IEA
Genome Projecthormone-mediated signaling pathway
GO:0010667
IEA
Genome Projectnegative regulation of cardiac muscle cell apoptotic process
GO:0010811
ISO
IEA
Genome Projectpositive regulation of cell-substrate adhesion
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IBA
Genome Projectcell migration
GO:0018108
IDA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019221
ISO
TAS
Genome Projectcytokine-mediated signaling pathway
GO:0022408
IEA
Genome Projectnegative regulation of cell-cell adhesion
GO:0030099
IMP
Genome Projectmyeloid cell differentiation
GO:0030154
IMP
Genome Projectcell differentiation
GO:0030155
IBA
Genome Projectregulation of cell adhesion
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0031103
IEA
Genome Projectaxon regeneration
GO:0031959
IEA
Genome Projectmineralocorticoid receptor signaling pathway
GO:0032024
IEA
Genome Projectpositive regulation of insulin secretion
GO:0032516
IEA
Genome Projectpositive regulation of phosphoprotein phosphatase activity
GO:0032731
IEA
Genome Projectpositive regulation of interleukin-1 beta production
GO:0033160
IEA
Genome Projectpositive regulation of protein import into nucleus, translocation
GO:0033194
IEA
Genome Projectresponse to hydroperoxide
GO:0033209
ISO
IEA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034050
IDA
Genome Projecthost programmed cell death induced by symbiont
GO:0034612
ISO
IEA
Genome Projectresponse to tumor necrosis factor
GO:0035409
ISO, IBA
IEA
Genome Projecthistone H3-Y41 phosphorylation
GO:0035556
IDA
IEA
Genome Projectintracellular signal transduction
GO:0035722
ISO
IEA
Genome Projectinterleukin-12-mediated signaling pathway
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042503
IEA
Genome Projecttyrosine phosphorylation of Stat3 protein
GO:0042506
IEA
Genome Projecttyrosine phosphorylation of Stat5 protein
GO:0042508
IEA
Genome Projecttyrosine phosphorylation of Stat1 protein
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043388
IEA
Genome Projectpositive regulation of DNA binding
GO:0043392
IDA
Genome Projectnegative regulation of DNA binding
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045087
IBA
Genome Projectinnate immune response
GO:0045429
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045597
IEA
Genome Projectpositive regulation of cell differentiation
GO:0045822
IEA
Genome Projectnegative regulation of heart contraction
GO:0045944
IGI
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046677
ISO
IEA
Genome Projectresponse to antibiotic
GO:0048008
IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0050727
ISO
IEA
Genome Projectregulation of inflammatory response
GO:0050729
IEA
Genome Projectpositive regulation of inflammatory response
GO:0050867
IEA
Genome Projectpositive regulation of cell activation
GO:0051091
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051770
IEA
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0060333
IEA
Genome Projectinterferon-gamma-mediated signaling pathway
GO:0060396
ISO
IEA
Genome Projectgrowth hormone receptor signaling pathway
GO:0061180
IMP
Genome Projectmammary gland epithelium development
GO:0070671
ISO
IEA
Genome Projectresponse to interleukin-12
GO:0071222
IDA
Genome Projectcellular response to lipopolysaccharide
GO:0071549
IDA
Genome Projectcellular response to dexamethasone stimulus
GO:0097191
IDA
Genome Projectextrinsic apoptotic signaling pathway
GO:2001235
IMP
Genome Projectpositive regulation of apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IDA, IMP
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IBA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005102
ISO
IEA
Genome Projectreceptor binding
GO:0005131
IBA
IEA
Genome Projectgrowth hormone receptor binding
GO:0005143
IPI
Genome Projectinterleukin-12 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008022
IEA
Genome Projectprotein C-terminus binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
ISO
IEA
Genome Projectprotein kinase binding
GO:0020037
ISO
IEA
Genome Projectheme binding
GO:0031702
IEA
Genome Projecttype 1 angiotensin receptor binding
GO:0033130
IEA
Genome Projectacetylcholine receptor binding
GO:0035401
ISO, IBA
IEA
Genome Projecthistone kinase activity (H3-Y41 specific)
GO:0042169
ISO
IEA
Genome ProjectSH2 domain binding
GO:0042393
ISO
IEA
Genome Projecthistone binding
GO:0043548
IEA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0043560
IEA
Genome Projectinsulin receptor substrate binding
GO:0051428
IEA
Genome Projectpeptide hormone receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISO
IEA
Genome Projectnucleus
GO:0005737
ISO
TAS, IEA
Genome Projectcytoplasm
GO:0005829
IEA
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005901
IDA
Genome Projectcaveola
GO:0016020
IEA
Genome Projectmembrane
GO:0016363
IEA
Genome Projectnuclear matrix
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0045121
IDA
Genome Projectmembrane raft

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000299FERM domain
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR016251Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR017441Protein kinase, ATP binding site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR020635Tyrosine-protein kinase, catalytic domain
IPR020693Tyrosine-protein kinase, non-receptor Jak2

No MapMan annotations defined for this gene.