Gene: ENSMUSG00000024621 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000024621
Transcript Identifier
ENSMUST00000115268
Gene Type
Coding gene
Location
18 : 61105950-61130480 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P024299
(4 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
colony stimulating factor 1 receptor

Identifiers

Type Value
UniprotP09581
UniprotQ0P635
MGI1339758

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001934
ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0002376
IEA
Genome Projectimmune system process
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006954
IEA
Genome Projectinflammatory response
GO:0007169
IDA, IMP
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411
IMP
Genome Projectaxon guidance
GO:0007519
IEA
Genome Projectskeletal muscle tissue development
GO:0008283
ISO
IEA
Genome Projectcell proliferation
GO:0008284
IMP
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IMP
Genome Projectnegative regulation of cell proliferation
GO:0008360
IMP
ISO
IEA
Genome Projectregulation of cell shape
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
ISO
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019221
ISO
IEA
Genome Projectcytokine-mediated signaling pathway
GO:0021772
IMP
Genome Projectolfactory bulb development
GO:0021879
IMP
Genome Projectforebrain neuron differentiation
GO:0030097
ISO
IEA
Genome Projecthemopoiesis
GO:0030316
IMP
Genome Projectosteoclast differentiation
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0031529
IMP
Genome Projectruffle organization
GO:0036006
IMP
ISO
IEA
Genome Projectcellular response to macrophage colony-stimulating factor stimulus
GO:0038145
IDA
ISO
IEA
Genome Projectmacrophage colony-stimulating factor signaling pathway
GO:0042517
IMP
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0045087
IEA
Genome Projectinnate immune response
GO:0045124
ISS
Genome Projectregulation of bone resorption
GO:0045217
ISO
IEA
Genome Projectcell-cell junction maintenance
GO:0045672
IEA
Genome Projectpositive regulation of osteoclast differentiation
GO:0046488
IMP
Genome Projectphosphatidylinositol metabolic process
GO:0046777
IDA
ISO
IEA
Genome Projectprotein autophosphorylation
GO:0048015
IMP
Genome Projectphosphatidylinositol-mediated signaling
GO:0061098
ISO
IEA
Genome Projectpositive regulation of protein tyrosine kinase activity
GO:0070374
IMP
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071345
IMP
Genome Projectcellular response to cytokine stimulus
GO:0071902
IMP
Genome Projectpositive regulation of protein serine/threonine kinase activity
GO:0090197
ISO
IEA
Genome Projectpositive regulation of chemokine secretion
GO:2000147
ISO
IEA
Genome Projectpositive regulation of cell motility
GO:2000249
IMP
Genome Projectregulation of actin cytoskeleton reorganization

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005011
IDA, IMP
ISO
IEA
Genome Projectmacrophage colony-stimulating factor receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019903
IPI
Genome Projectprotein phosphatase binding
GO:0019955
IDA, IPI
ISO
IEA
Genome Projectcytokine binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IMP
Genome Projectintracellular
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:1990682
IDA
Genome ProjectCSF1-CSF1R complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001824Tyrosine-protein kinase, receptor class III, conserved site
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR013151Immunoglobulin
IPR013783Immunoglobulin-like fold
IPR016243Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR030658Macrophage colony-stimulating factor 1 receptor

No MapMan annotations defined for this gene.