Gene: ENSMUSG00000024620 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000024620
Transcript Identifier
ENSMUST00000115274
Gene Type
Coding gene
Location
18 : 61046095-61083383 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
platelet derived growth factor receptor, beta polypeptide

Identifiers

Type Value
UniprotE9QN12
MGI97531

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001701
IMP
Genome Projectin utero embryonic development
GO:0001822
IMP
Genome Projectkidney development
GO:0001894
IMP
Genome Projecttissue homeostasis
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006807
IMP
Genome Projectnitrogen compound metabolic process
GO:0006935
IEA
Genome Projectchemotaxis
GO:0007165
IDA
ISO
Genome Projectsignal transduction
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0008284
ISO
Genome Projectpositive regulation of cell proliferation
GO:0010863
ISO
Genome Projectpositive regulation of phospholipase C activity
GO:0014911
ISO
Genome Projectpositive regulation of smooth muscle cell migration
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
ISO
Genome Projectcell migration
GO:0018108
ISO
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030325
IGI
Genome Projectadrenal gland development
GO:0030335
ISO
Genome Projectpositive regulation of cell migration
GO:0032516
ISO
Genome Projectpositive regulation of phosphoprotein phosphatase activity
GO:0035791
ISO
Genome Projectplatelet-derived growth factor receptor-beta signaling pathway
GO:0038091
ISO
Genome Projectpositive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552
ISO
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0046488
ISO
Genome Projectphosphatidylinositol metabolic process
GO:0046777
ISO
Genome Projectprotein autophosphorylation
GO:0048008
IMP
ISO
IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0048015
ISO
Genome Projectphosphatidylinositol-mediated signaling
GO:0048661
ISO
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0048705
IMP
Genome Projectskeletal system morphogenesis
GO:0048745
IMP
Genome Projectsmooth muscle tissue development
GO:0050730
IMP
Genome Projectregulation of peptidyl-tyrosine phosphorylation
GO:0060326
ISO
Genome Projectcell chemotaxis
GO:0070374
ISO
Genome Projectpositive regulation of ERK1 and ERK2 cascade

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004871
IDA
Genome Projectsignal transducer activity
GO:0005019
ISO
IEA
Genome Projectplatelet-derived growth factor beta-receptor activity
GO:0005102
ISO
Genome Projectreceptor binding
GO:0005161
ISO
Genome Projectplatelet-derived growth factor receptor binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IMP
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
ISO
Genome Projectprotein kinase binding
GO:0038085
ISO
Genome Projectvascular endothelial growth factor binding
GO:0048407
ISO
Genome Projectplatelet-derived growth factor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005764
IEA
Genome Projectlysosome
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005925
ISO
Genome Projectfocal adhesion
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016023
IEA
Genome Projectcytoplasmic membrane-bounded vesicle
GO:0031226
ISO
Genome Projectintrinsic component of plasma membrane
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0043202
IEA
Genome Projectlysosomal lumen
GO:0070062
ISO
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001824Tyrosine-protein kinase, receptor class III, conserved site
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR013151Immunoglobulin
IPR013783Immunoglobulin-like fold
IPR016243Tyrosine-protein kinase, CSF-1/PDGF receptor family
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain
IPR027288Platelet-derived growth factor receptor beta

No MapMan annotations defined for this gene.